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Human body oxidative stress non-invasive fluorescence detection device and method

A technology for oxidative stress and fluorescence detection, applied in applications, diagnostic recording/measurement, medical science, etc., can solve problems such as interference, no compensation or correction of fluorescence spectrum, no proposed device for disease diagnosis, etc., to achieve detection speed. The effect of quickness, avoiding pain and the risk of infection

Inactive Publication Date: 2010-06-02
ANHUI INST OF OPTICS & FINE MECHANICS - CHINESE ACAD OF SCI
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Problems solved by technology

The inventors proposed that the advanced glycation end products in the skin could be quantitatively detected by skin fluorescence, but did not describe any method for the quantitative measurement of AGE using the device, and did not propose the use of the device in disease diagnosis
No method is proposed to compensate or correct fluorescence spectra for interference of fluorescence measurements by individual skin color and structure

Method used

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  • Human body oxidative stress non-invasive fluorescence detection device and method
  • Human body oxidative stress non-invasive fluorescence detection device and method
  • Human body oxidative stress non-invasive fluorescence detection device and method

Examples

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Embodiment

[0063] The non-invasive fluorescence detection device for human oxidative stress includes an excitation light source system, a spectrum acquisition system and a spectrum signal analysis and processing system.

[0064] Example 1 of such a detection device includes a high-power xenon lamp, a monochromator, and a coupling lens set as the core components of the excitation light source system; including a conducting fiber, a fiber probe, and a spectrometer as a spectrum acquisition system, wherein the fiber probe such as figure 2 As shown in (a), it is a combination of 1 central fiber and 12 edge fibers. The conducting fiber and the fiber probe are connected by the fiber interconnector. The spectrometer is a high-precision spectrometer that can detect spectral signals in the 350nm-600nm band; Analysis system computer and analysis processing software.

[0065] In Example II, the high-power xenon lamp, monochromator, and coupling lens set in Example I were replaced with near-ultravi...

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Abstract

The invention discloses human body oxidative stress non-invasive fluorescence detection device and method. An excitation light source system comprises one near ultraviolet light source and one light filter and one beam splitter which are arranged on the emergent light path of near ultraviolet light source; wherein the beam splitter splits the emergent light into a reference light and an exciting light. A spectrum acquisition system comprises a conduction optical fiber, a fiber probe and a spectrometer. The conduction optical fiber is used for transmitting the reference light to the spectrometer; the fiber probe is used for transmitting the exciting light to skin part of human body to be tested, collecting fluorescent light generated by excitation on skin of human body and transmitting the fluorescent light to the spectrometer. The spectrometer is used for analyzing and processing the collected spectrum signal and finally obtains oxidative stress status of the detected object. Autofluorescence of skin is utilized to reflect human body oxidative stress status, detection speed is rapid, and result can be displayed in real time. The invention can provide reliable basis for prevention, diagnose and treatment effect evaluation on critical illness.

Description

technical field [0001] The invention relates to a method and device for non-invasive detection of human body, in particular to a method and device for detecting oxidative stress state of human body using tissue fluorescence. Background technique [0002] Oxidative stress refers to excessive production or reduced elimination of highly reactive molecules such as reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the body, resulting in tissue damage. Under normal conditions, the body can produce a small amount of ROS to participate in normal metabolism. At the same time, there is a system that scavenges free radicals and inhibits the reaction of free radicals, so that excessive free radicals are scavenged or free radicals are reduced, and the generation and scavenging of free radicals maintain a balance; However, in some pathological states, this mechanism is destroyed, and free radicals in the body increase significantly. Excessive free radicals can directly ...

Claims

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Application Information

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IPC IPC(8): A61B5/00A61B5/1455
Inventor 张龙王贻坤夏营威朱灵吴晓松李志刚朱震刘勇王安
Owner ANHUI INST OF OPTICS & FINE MECHANICS - CHINESE ACAD OF SCI
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