Method for preparing repairing material of antibacterial degradable active nanometer composite bionic tone tissue

A nano-composite and tissue repair technology, applied in the field of biomedical engineering, can solve the problems of multi-animal experiments and clinical trials, and achieve the effects of good environment, high output, and simple operation
CN101721750BInactive Publication Date: 2013-08-07ANHUI MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ANHUI MEDICAL UNIV
Publication Date
2013-08-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a method for preparing repairing material of antibacterial degradable active nanometer composite bionic tone tissue, comprising the following steps of: A, preparing a calcium-phosphorus solution with calcium chloride, sodium dihydrogen phosphate and the like, and mixing the calcium-phosphorus solution, the minocycline solution and the aqueous solution of gelation; B, carrying out reaction on the mixed solution in a silicone oil reactive bath; C, standing in motionless and ageing at the room temperature; D, centrifugalizing the aged substance to obtain the precipitate;freezing and drying the precipitate to obtain the repairing material for the bionic nanometer composite bionic bone tissue. The method adopts molecular bionic synthesis technology, simulates the process of bone mineralization and takes gelatine with excellent biocompatibility as an organic molecule template that regulates and controls growth of apatite (primary inorganic component of bone tissue)under physiologic condition to carry out biomimetic synthesis of repairing material for organic-inorganic composite bone tissue. Meanwhile, the antibacterial agent minocycline in the process of the growth of apatite crystal is loaded. Therefore, a novel antibacterial repairing material of nanometer composite bionic tone tissue is synthesized.
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Description

technical field

[0001] The invention belongs to biomedical engineering technology, and relates to a preparation method for bone defect repair materials used in orthopedics, extracerebral and oral cavity clinics. Background technique

[0002] The repair of human hard tissue defects caused by inflammation, trauma, tumors and the aging of society is a difficult problem to be solved in stomatology and clinical medicine. According to reports, the current annual turnover of biomaterials in the world is 12 billion US dollars, of which the human body hard-woven replacement materials are about 2.3 billion US dollars. And it is growing at a rate of 7%-12% per year. According to the report of the civil affairs department, there are about 8 million disabled patients in my country at present, and 3 million patients with bone defects in the whole country every year, and 20-33% of the total number of patients with tooth defects. Therefore, materials for repairing human hard tissue defects...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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