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Functional artificial joint on surface of cerium-loaded nanotube array and preparation method thereof

A nanotube array, artificial joint technology, applied in medical science, prostheses, coatings, etc., can solve the problems of not being able to distribute evenly for a long time, difficult to exert the osteogenic effect, etc., to inhibit the growth of bacteria and induce osteogenesis. effect, the effect of reducing the inflammatory response

Inactive Publication Date: 2010-06-23
江苏广达医材集团有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

BMP degrades rapidly in local tissues or diffuses with body fluids, and cannot be distributed evenly in bone defects for a long time, making it difficult to exert an ideal osteogenic effect
The effect of simply applying exogenous BMP to treat bone defects is not ideal, so it must be compounded with a suitable carrier material to play a role in the sustained release of BMP

Method used

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  • Functional artificial joint on surface of cerium-loaded nanotube array and preparation method thereof
  • Functional artificial joint on surface of cerium-loaded nanotube array and preparation method thereof
  • Functional artificial joint on surface of cerium-loaded nanotube array and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) First choose titanium alloy to process the artificial joint;

[0031] (2) Artificial joint surface pretreatment: After the surface is polished, wash it with acetone, deionized water and absolute ethanol in sequence for 10-30 minutes, and then wash it with HF and HNO 3 and water (volume ratio: 1:4:5) chemically polish for 20-40 seconds, rinse thoroughly with deionized water, and dry for use;

[0032] (3) Preparation of aqueous organic electrolyte solution: using ethylene glycol as a solvent, other active ingredients are: water 2vol% (volume percent), phosphoric acid 4vol% (volume percent), ammonium fluoride 0.3wt% (mass percent);

[0033](4) Preparation of titanium dioxide nanotubes by two-step anodization: the surface pretreated artificial joint is used as the anode, graphite or platinum sheet is used as the cathode, and the first anodization is carried out in an aqueous organic electrolyte solution. The specific anodization parameters are: voltage 60V, the reactio...

Embodiment 2

[0038] (1) First choose titanium to process the artificial joint;

[0039] (2) Artificial joint surface pretreatment: After the surface is polished, wash it with acetone, deionized water and absolute ethanol in sequence for 30-60 minutes, and then wash it with HF and HNO 3 and water (volume ratio: 1:4:5) chemically polish for 40-60 seconds, then rinse thoroughly with deionized water, and blow dry with a hair dryer for use;

[0040] (3) Preparation of aqueous organic electrolyte solution: using ethylene glycol as a solvent, other active ingredients are: water 2vol% (volume percent), phosphoric acid 4vol% (volume percent), ammonium fluoride 0.5wt% (mass percent);

[0041] (4) Preparation of titanium dioxide nanotubes by two-step anodization: the surface pretreated artificial joint is used as the anode, graphite or platinum sheet is used as the cathode, and the first anodization is carried out in an aqueous organic electrolyte solution. The specific anodization parameters are: vo...

Embodiment 3

[0046] (1) First choose titanium alloy to process the artificial joint;

[0047] (2) Artificial joint surface pretreatment: after surface polishing, wash with acetone, deionized water and absolute ethanol in sequence for 60-90 minutes, and then wash with HF and HNO 3 and water (volume ratio: 1:4:5) chemically polish for 60-80 seconds, then rinse thoroughly with deionized water, and blow dry with a hair dryer for use;

[0048] (3) Preparation of aqueous organic electrolyte solution: using ethylene glycol as a solvent, other active ingredients are: water 4vol% (volume percent), phosphoric acid 6vol% (volume percent), ammonium fluoride 0.5wt% (mass percent);

[0049] (4) Preparation of titanium dioxide nanotubes by two-step anodization: the surface pretreated artificial joint is used as the anode, graphite or platinum sheet is used as the cathode, and the first anodization is carried out in an aqueous organic electrolyte solution. The specific anodization parameters are: voltage ...

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Abstract

The invention relates to a functional artificial joint on surface of cerium-loaded nanotube array and preparation method thereof. The surface of the metal substrate of the artificial joint is provided with one cerium-doped sodium titanate nanotube array layer with a tubular structure; the inside of the layer thereof is further loaded with a bone morphogenetic protein (BMP). The preparation methodfor the functional artificial joint on surface of cerium-loaded nanotube array includes the steps: selecting pure titanium or titanium alloy to process the artificial joint; then adopting two-step oxidation technique to obtain a titanium dioxide nanotube array layer on the surface of the pure titanium or titanium alloy artificial joint; then adopting alkali liquor hydrothermal synthesis techniqueto transform the titanate nanotube array layer into sodium titanate nanotube array layer; doping rare-earth element cerium in the sodium titanate nanotube array layer through solution pickling ion exchange, and finally adopting a centrifugal loading technique to load the bone morphogenetic protein in the cerium-doped sodium titanate nanotube array layer.

Description

technical field [0001] The present invention relates to an artificial joint with functionalized cerium-loaded nanotube array surface and a preparation method thereof, in particular to an artificial joint with cerium-doped sodium titanate nanotubes loaded with bone morphogenetic protein (BMP) on the surface and its preparation The method belongs to the technical field of artificial joint materials. Background technique [0002] Every year, about 1.5 million patients with joint loss due to degenerative and inflammatory arthritis need artificial joint replacement. Among them, the application of metal materials in the manufacture of artificial joints is the earliest, and it is still the most widely used in clinical practice. Over time and clinical studies have shown that artificial joints made of metal materials commonly loosen, sink or break, causing bone resorption, which is one of the main complications affecting the long-term efficacy of artificial joint replacement. [00...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/28A61L27/06A61L27/54
Inventor 储成林郭超
Owner 江苏广达医材集团有限公司
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