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Method for synthesizing gold-doped fluorescent quantum dots

A technology of fluorescent quantum dots and a synthesis method, which is applied in the field of nanomaterial preparation to achieve the effects of strong fluorescent signal, improved biocompatibility, and uniform size distribution

Inactive Publication Date: 2010-06-23
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, no gold-doped fluorescent quantum dots have been reported

Method used

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  • Method for synthesizing gold-doped fluorescent quantum dots
  • Method for synthesizing gold-doped fluorescent quantum dots
  • Method for synthesizing gold-doped fluorescent quantum dots

Examples

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Embodiment 1

[0024] 1. Preparation of potassium hydride telluride

[0025] Add 26 mg of tellurium powder, 42 mg of potassium borohydride and 2 ml of ultrapure water into a 5 ml glass reagent bottle, pass through the bottle with argon gas, put in a magnetic rotor, and cover with a rubber stopper equipped with a micro-exhaust tube. A micro-exhaust pipe is used to discharge the hydrogen gas produced by the reaction. Stir with a magnetic stirrer and react under anaerobic conditions for 3 hours, and the colorless supernatant is potassium hydride telluride solution.

[0026] 2. Cd n Au x Te y Aqueous Phase Synthesis of Fluorescent Quantum Dots

[0027] 46 mg of cadmium chloride (CdCl 2 2.5H 2 O), 56 milligrams of L-cysteine ​​were dissolved in 200 milliliters of ultrapure water, and 200 microliters of gold chloride (AuCl 3 ·HCl·4H 2 O) aqueous solution, fully mixed, dropwise concentration of 1 mol / liter of sodium hydroxide solution to adjust the pH to 8. The above solution was stirred...

Embodiment 2

[0029] Preparation of potassium hydride telluride

[0030] 1. Add 26 mg of tellurium powder, 40 mg of potassium borohydride and 2 ml of ultrapure water into a 5 ml glass reagent bottle, pass through the bottle with argon gas, put in the magnetic rotor, and cover with a rubber stopper equipped with a micro-exhaust tube . A micro-exhaust pipe is used to discharge the hydrogen gas produced by the reaction. Stir with a magnetic stirrer and react under anaerobic conditions for 3 hours, and the colorless supernatant is potassium hydride telluride solution.

[0031] 2. Cd n Au x Hg y Te z Aqueous Phase Synthesis of Quaternary Fluorescent Quantum Dots

[0032] 46 mg of cadmium chloride (CdCl 2 2.5H 2 O), 66 milligrams of L-cysteine ​​are dissolved in 200 milliliters of ultrapure water, and adding 200 microliters of concentrations is 0.1 mol / liter of mercuric chloride aqueous solution, and 200 microliters of concentrations are 0.1 moles / liter of gold chloride (AuCl 3 ·HCl·4H ...

Embodiment 3

[0034] 1. Preparation of potassium hydride telluride

[0035] Add 26 mg of tellurium powder, 30 mg of potassium borohydride and 2 ml of ultrapure water into a 5 ml glass reagent bottle, pass through the bottle with argon gas, put in a magnetic rotor, and cover with a rubber stopper equipped with a micro-exhaust tube. A micro-exhaust pipe is used to discharge the hydrogen gas produced by the reaction. Stir with a magnetic stirrer, react for 4 hours under anaerobic conditions, and the colorless supernatant is potassium hydride telluride solution.

[0036] 2. Cd n Au x Hg y Te z Aqueous Phase Synthesis of Quaternary Fluorescent Quantum Dots

[0037] 46 mg of cadmium chloride (CdCl 2 2.5H 2 0), 20 milligrams of glutathione and 42 milligrams of L-cysteine ​​(two kinds of mercapto compound combinations) are dissolved in 200 milliliters of ultrapure water, and adding 300 microliters of concentrations is 0.2 mol / liter of mercuric chloride aqueous solution, 100 microliters of g...

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Abstract

The invention provides a method for synthesizing gold-doped fluorescent quantum dots, which performs water phase synthesis on a cadmium salt, a compound of gold, a mercury salt, a sulfhydryl compound and newly-prepared tellurium potassium hydride under an anaerobic condition at the temperature of between 90 and 130 DEG C to obtain CdnAuxTez and near infrared CdnAuxHgyTez gold-doped fluorescent quantum dots. The gold-doped fluorescent quantum dots synthesized by the method are slightly poisonous, have strong fluorescence signals, have an emission spectrum positioned at visible and near infrared light, contain the gold element, and can be used for performing analytical studies correlative with a gold nano material; and the wavelength can be adjusted according to the proportion of componentsand the reaction time. The method dopes gold which has no bio-toxicity into semiconductor quantum dots to improve the biological compatibility of the quantum dots and reduce the nano-toxicity. The method can be applied in the fields of biological analytic detections, biomedical imaging and the like.

Description

technical field [0001] The invention belongs to the field of nanomaterial preparation technology, biological analysis and detection technology and biomedical imaging technology, and relates to Cd n Au x Te z and Cd n Au x Hg y Te z A synthetic method of gold-doped fluorescent quantum dots (n, x, y, z in the chemical formula represent the ratio of moles). Background technique [0002] Quantum dots are semiconductor nanocrystals with unique optoelectronic properties. Compared with traditional organic dyes and fluorescent proteins, quantum dots have the following advantages: high brightness and photostability, the fluorescence emission wavelength can be adjusted by changing the size and composition, and the emission wavelength range can range from visible light to infrared. As a new type of fluorescent probe, quantum dots have great application potential in the fields of bioanalysis detection technology and biomedical imaging technology. [0003] In vivo imaging using q...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/89C09K11/88
Inventor 牟颖韩四海金伟
Owner ZHEJIANG UNIV
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