Phenolic compound synthesizing method taking water as solvent

A technology of phenolic compounds and synthesis methods, which is applied in the field of synthesis and preparation of chemical products, can solve problems such as pollution and high yields, and achieve the effects of cheap and easy-to-obtain reaction raw materials, high yields, and low environmental pollution
CN101774873AInactive Publication Date: 2010-07-14TSINGHUA UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
TSINGHUA UNIV
Publication Date
2010-07-14
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a phenolic compound synthesizing method taking water as a solvent. Under a mild reaction condition, the method takes aryl halides as the raw material, takes water as the solvent, takes alkali metal hydroxides (including sodium, potassium, cesium and the like) as alkalis, takes cuprous oxide, cuprous iodide, cuprous bromide or cuprous chloride as the catalyst, takes 2-pyridine formaldoxime as a ligand and takes 4-n-butyl ammonium bromide as the phase transfer catalyst, the reaction temperature is about 100-110 DEG C, and then phenolic compound is efficiently synthesized. Compared with the conventional phenolic synthesis method, the method takes the cheap and easily obtained aryl halides as the raw materials, takes the cheapest water as the solvent and takes the cheap cuprous oxide as the catalyst, the reaction condition is mild, the environmental pollution is small, the yield of generated phenol is high, the tolerance on various functional groups on an aromatic ring is high, separation and purification are convenient and the like, and the method can be widely applied in synthesis in the fields of medicines, polymers, natural products and the like of industrial community and academia.
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Description

technical field

[0001] The present invention generally relates to the synthesis and preparation of a class of chemical products, and more specifically relates to the synthesis method of phenolic compounds. Background technique

[0002] Phenolic compounds are important chemical raw materials and intermediates. Taking the most common phenol as an example, phenol can be used as a fungicide, anesthetic, and preservative. Joseph Lister (Lister J) first used it for surgical disinfection. Now phenol can be used to prepare disinfectants, and its dilute solution can be used for direct disinfection. Phenol is mainly used in the manufacture of phenolic resins, bisphenol A and caprolactam. Alkylphenols produced from phenol are monomers for preparing alkylphenol-formaldehyde polymers, and can be used as antioxidants, nonionic surfactants, plasticizers, and petroleum product additives. Phenol is also a raw material for many medicines (such as salicylic acid, aspirin and sulfa drugs, e...

Claims

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