Application of polygonin atomizing agent as asthma-treating medicine

A treatment drug, polydatin technology, which is applied in the direction of drug combination, drug delivery, aerosol delivery, etc., can solve the problems of no gastrointestinal degradation, strict requirements on properties, size, and shape, and few varieties of Chinese patent medicines. , to achieve the effects of being beneficial to environmental protection, saving manufacturing costs, and simplifying the types of medication

Inactive Publication Date: 2010-08-04
江庆澜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] 1. No gastrointestinal degradation;
[0006] 2. No hepatic first pass effect;
[0017] 1. The curative effect of western medicine is fast, but there are many kinds of medicines used at the same time in comprehensive treatment, and the methods are cumbersome, and many of them (such as hormones, theophylline, antibiotics, etc.) have serious side effects
[0018] 2. The method of taking traditional Chinese medicine is troublesome and the effect is slow
There are few varieties of Chinese patent medicines, and the only asthma medicines containing polydatin are oral preparations and plasters. These two dosage forms are not the best way of administration for asthma treatment. So far, the curative effect has yet to be verified and has not been standardized in the clinical practice of asthma. treat
[0019] 3. Among the inhaled dosage forms of asthma treatment drugs, aerosols are the most commonly used, but the propellants contained in them have obvious side effects on the human body and cause environmental pollution problems, especially the main propellants of current medical aerosols—— Fluorochloroalkanes (Freons) have the disadvantage of destroying the ozone layer of the atmosphere, and have been fully banned by the Montreal Treaty signed by more than 140 countries
[0020] 4. Inhalation medicine liquid directly acts on the airway lesion, and has specific requirements on physical and chemical properties (such as water solubility, viscosity, irritation, pH value, sensitization, etc.), compared with oral and Ointment dosage forms have more stringent requirements on the nature, size and shape of drug particles, which restricts the development and application of Chinese patent medicines or traditional Chinese medicine extract monomer inhalation dosage forms
At present, there are many studies on the application of polydatin in cardiovascular and cerebrovascular diseases and infectious inflammation, but the research on the mechanism (especially the molecular mechanism) and dosage forms of polydatin in treating asthma is extremely weak, and there is still no report on inhalation therapy and its applicable dosage forms.

Method used

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  • Application of polygonin atomizing agent as asthma-treating medicine
  • Application of polygonin atomizing agent as asthma-treating medicine
  • Application of polygonin atomizing agent as asthma-treating medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1 Pre-experiment

[0040] 1. Asthma rat model: female SD rats, weighing 240-260g. The experimental rats were divided into 7 groups (including the normal control group, high, medium and low doses of polydatin oral intervention groups and high, medium and low doses of polydatin inhalation intervention groups), with 5 rats in each group. Rats in each group were fed with standard feed and free to eat and drink. Each polydatin oral or inhalation intervention group was sensitized on the first day by intraperitoneal and subcutaneous injection of 10% ovalbumin (OVA, Sigma, Z010101) and 3% aluminum hydroxide mixture at a dose of 1ml / body, and after a lapse of 1 week, the On the 8th day, the sensitization was boosted once with the same dose and the same method. The normal control group was injected intraperitoneally and subcutaneously with equal volume of normal saline.

[0041]2. Drug intervention and control experiments: on the 15th day after sensitization, low-do...

Embodiment 2

[0049] Example 2 Preparation of Polydatin Spray and Experimental Study on Therapeutic Effect of Atomization Inhalation

[0050] 1. Asthma rat model: SPF grade female SD rats, provided by Guangdong Medical Experimental Animal Center (Yuejian Zhengzi 2008A020), weighing 140-160g. The experimental rats were divided into 4 groups, including normal control group, asthma control group, aminophylline intervention group and polydatin intervention group, with 10 rats in each group. Rats in each group were fed with standard feed and free to eat and drink. Rats in the asthma control group, polydatin intervention group and aminophylline intervention group were sensitized on the first day by intraperitoneal and subcutaneous injection of 10% OVA and 3% aluminum hydroxide mixture at a dose of 1ml / rat. On the 8th day, the sensitization was boosted once with the same dose and the same method. The normal control group was injected intraperitoneally and subcutaneously with equal volume of norm...

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Abstract

The invention discloses an application of a polygonin atomizing agent as asthma-treating medicine. Each 1000 ml of polygonin spraying agent comprises 1 g of polygonin, 50 ml of propylene glycol, 1 g of sodium pyrosulfite, and the balance of water. Polygonin is prepared in the atomizing agent for the first time in the invention, and thus, the curative effect of asthma treatment is greatly increased through an administration method of atomizing inhalation. The molecular mass of polygonin is small, and the polygonin has the characteristics of fat solubility and no taste; the polygonin has certain solubility in airway secretion fluid or alveolar fluid, can be quickly absorbed through the membrane of an epithelial cell so as to arrive at a target cell and exert the efficacy for relieving asthma and diminishing inflammation, and is suitably prepared into the atomizing agent without adding more additives; asthma is treated through the administration method of atomizing inhalation, and the curative effect of the polygonin atomizing agent is superior to a peroral dosage form of polygonin. Compared with other various dosage forms, the polygonin atomizing agent effectively saves dosage and manufacturing cost, reduces bad effect on patients, and is beneficial to environment protection.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to the field of medicinal use of polydatin. Background technique [0002] Bronchial asthma (asthma for short) is pathological changes such as bronchial smooth muscle spasm, mucosal edema, and increased mucus secretion caused by sensitizing factors or non-sensitizing factors acting on the body. It is composed of various cells, especially eosinophils (EOS), Inflammatory cells such as mast cells, T lymphocytes, neutrophils (NEUT) and airway epithelial cells and their various cellular components participate in chronic airway allergic inflammation, which can occur in people of all age groups. Respiratory disease with high morbidity and mortality. The pathogenesis of asthma is complex, most of which are stimulated by certain factors inside and outside the body on the basis of heredity. So far, its pathogenesis has not been fully understood. Since there is no ideal method and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K9/72A61K31/7034A61P11/06
Inventor 江庆澜
Owner 江庆澜
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