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Extraction separation method of L-synephrine

An extraction and raffinate technology, which is applied in the field of extracting and separating L-synephrine by using reverse micellar extraction technology, can solve the problems of poor reusability of silica gel, poor fluidity of extract solution, unfavorable large-scale production, etc., and achieve the elimination of digestive tract Discomfort in the system, promote appetite, and be beneficial to the effect of environmental protection

Inactive Publication Date: 2010-08-04
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main disadvantages of this method are: the extract containing 80% to 85% of solids has poor fluidity, is not easy to be loaded on the column, has large mass transfer resistance, high energy consumption, and low efficiency; Poor reusability and large resource consumption; use of toxic organic solvents such as methanol and methylene chloride causes serious pollution and poor production safety, which is not conducive to large-scale production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A method for extracting and separating L-synephrine, the specific method steps are as follows:

[0032] (1) Alcohol dissolution and suction filtration

[0033]Taking commercially available Fructus Fructus Aurantii as raw material, with 60% ethanol solution as solvent, by the ratio of the mass (g) of Fructus Fructus Fructus Ethanol: the volume (mL) of 60% ethanol solution is the ratio of 1: 9, add volume in Fructus Fructus Fructus The ethanol solution with a fraction of 60% was stirred and dissolved for 20 minutes, then suction filtered, and the filtrate and filter residue were collected respectively. The collected filtrate is used for ultrafiltration in the next step. For the filter residue, because it contains a large amount of polysaccharides, it is used as a fermentation additive for edible fungi after drying.

[0034] (2) Ultrafiltration separation

[0035] After the (1) step is completed, the filtrate collected in the (1) step is first pumped into the ultrafilte...

Embodiment 2

[0048] A method for extracting and separating L-synephrine, the specific method steps are as follows:

[0049] (1) Alcohol dissolution and suction filtration

[0050] With embodiment 1, wherein: the ratio of the mass (g) of citrus aurantium: the volume (mL) of 60% ethanol solution is the ratio of 1: 9, stirring and dissolving for 30 minutes.

[0051] (2) Ultrafiltration separation

[0052] With embodiment 1, wherein: to the filtrate collected in the (1) step, carry out ultrafiltration separation under 0.2MPa.

[0053] (3) reverse micellar extraction

[0054] ① Preparation of P204 reverse micellar solution

[0055] Same as Example 1, wherein: the molar concentration of P204 is 0.12mol / L. The molar ratio of distilled water:P204 added was 1:0.05.

[0056] ② reverse micellar extraction

[0057] Same as Example 1, wherein: P204 reverse micelle solution: the volume ratio of the L-synephrine extraction stock solution prepared in step (2) is 1:2, the pH value of the aqueous phas...

Embodiment 3

[0065] A method for extracting and separating L-synephrine, the specific method steps are as follows:

[0066] (1) Alcohol dissolution and suction filtration

[0067] With embodiment 1, wherein: the ratio of the mass (g) of citrus aurantium: the volume (mL) of 60% ethanol solution is the ratio of 1: 10, stirring and dissolving for 40 minutes.

[0068] (2) Ultrafiltration separation

[0069] With embodiment 1, wherein: to the filtrate collected in the (1) step, carry out ultrafiltration separation under 0.3MPa.

[0070] (3) reverse micellar extraction

[0071] ① Preparation of reverse micellar solution

[0072] Same as Example 1, wherein: the molar concentration of P204 is 0.10mol / L. The molar ratio of added distilled water:P204 extractant is 1:0.07.

[0073] ② reverse micellar extraction

[0074] Same as Example 1, wherein: P204 reverse micelle solution: the volume ratio of the L-synephrine extraction stock solution prepared in step (2) is 1:3, the pH value of the aqueou...

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Abstract

An extraction separation method of L-synephrine relates to a method for extracting L-synephrine by reversed micelles. The method is characterized by taking immature bitter orange in the market as the raw material and carrying out the processes of dissolution, air pump filtration, ultrafiltration separation, reversed micelles extraction, back extraction, vacuum concentration and freeze-drying to obtain the finished product. The high purity product can be produced at normal temperature and the production energy consumption can be reduced by the method; the production equipment is simple and is convenient to operate; such nontoxic substances as ethanol, distilled water and the like are mainly used in the production process and can be reused; and the stripped impurities can be reused; therefore, the method has the advantages of safe production, full utilization of substance resources, no three wastes discharge, low production cost and energy conservation and emission reduction. The L-synephrine prepared by the method can be extensively applied to the industries such as medicine, food, beverage, health care product and the like.

Description

1. Technical field [0001] The invention belongs to the technical field of L-synephrine separation and purification, and in particular relates to a method for extracting and separating L-synephrine by reverse micellar extraction technology. 2. Background technology [0002] L-synephrine, also known as p-hydroxyephrine, phenylephrine, etc., exists in the dried young fruit of the Rutaceae plant sour orange, the young fallen fruit of the Citrus plant orange, and the cactus plant Prickly Pear and other plants. Molecular alkaloids. L-Synephrine has the effect of constricting blood vessels, raising blood pressure and strong expansion of trachea and bronchi. It is used for shock, heart failure, and treatment of bronchial asthma; it can improve metabolism, increase energy level, oxidize fat, and have weight loss effect; it is A natural stimulant with no side effects. Therefore, synephrine is widely used in medicine, food, beverage and other health care industries. [0003] L-synep...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C215/60C07C213/10
Inventor 桑鲁燕周小华张桂罗云芳
Owner CHONGQING UNIV
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