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Preparation method of chitosan/polyvinyl alcohol/polylactic acid blended porous membrane

A technology of polyvinyl alcohol and chitosan, which is applied in medical science, absorbent pads, prostheses, etc., can solve problems affecting subsequent processes and increase costs, and achieve the effects of low price, high porosity, and wide sources

Inactive Publication Date: 2010-09-08
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the blended porous membranes of other materials have certain deficiencies in the selection of raw materials and the preparation process. For example, the mineralized silk protein / polymer composite porous material and its preparation method whose application number is 200410003454.0 require degumming. , Concentration treatment, the quality of degumming affects the subsequent process, which increases the cost of production

Method used

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  • Preparation method of chitosan/polyvinyl alcohol/polylactic acid blended porous membrane
  • Preparation method of chitosan/polyvinyl alcohol/polylactic acid blended porous membrane

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Dissolve 3g of chitosan in 97g by weight of 2% acetic acid solution at 40°C to form a homogeneous solution. Dissolve 5g of polylactic acid in 95g (99wt%) dimethyl sulfoxide solution at 25°C to form a homogeneous solution. Dissolve 7g of polyvinyl alcohol in 93g of deionized water at 100°C to form a uniform solution. Weigh 11.2g of chitosan solution, 0.6g of polyvinyl alcohol solution and 0.84g of polylactic acid solution, mix together at 25°C, stir for 30min, and defoam. Pour the defoamed mixed solution into a flat-bottomed stainless steel vessel, freeze at -80°C to -8°C for 12 hours, and then vacuum freeze-dry for 12 hours to obtain chitosan: polyvinyl alcohol: polylactic acid weight percent It is a chitosan / polyvinyl alcohol / polylactic acid blend porous membrane of 8:1:1.

Embodiment 2

[0027] Weigh 12.6g of chitosan solution, 2.7g of polyvinyl alcohol solution and 1.26g of polylactic acid solution, mix together at 25°C, stir for 30min, and defoam. Pour the defoamed mixed solution into a flat-bottomed stainless steel vessel, freeze at -80°C to -8°C for 12 hours, and then vacuum freeze-dry for 12 hours to prepare chitosan: polyvinyl alcohol: polyvinyl alcohol Chitosan / polyvinyl alcohol / polylactic acid blend porous membrane with a mass ratio of lactic acid of 6:3:1.

Embodiment 3

[0029] Weigh 11.2g of chitosan solution, 6g of polyvinyl alcohol solution and 1.68g of polylactic acid solution, mix together at 25°C, stir for 30min, and defoam. Pour the defoamed mixed solution into a flat-bottomed stainless steel vessel, freeze at -80°C to -8°C for 12 hours, and then vacuum freeze-dry for 12 hours to prepare chitosan: polyvinyl alcohol: polyvinyl alcohol Chitosan / polyvinyl alcohol / polylactic acid blended porous membrane with lactic acid weight percentage of 4:5:1.

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Abstract

The invention relates to a preparation method of a chitosan / polyvinyl alcohol / polylactic acid blended porous membrane, which comprises the following steps of: (1) using an acetic acid solution as the solvent to dissolve chitosan at 30-40 DEG C to obtain a chitosan solution of which the weight percentage is 3%; (2) using a dimethyl sulfoxide solution as the solvent to dissolve polyvinyl alcohol at room temperature to obtain a polyvinyl alcohol solution of which the weight percentage is 5%; (3) using deionized water as the solvent to dissolve polyvinyl alcohol at 80-120 DEG C, and stirring until the polyvinyl alcohol is completely dissolved to obtain a polyvinyl alcohol solution of which the weight percentage is 7%; (4) mixing the three solutions based on a certain ratio, stirring for 15-30 minutes at the constant temperature of 20-30 DEG C, standing, and defoaming; and (5) using a freeze drying method to prepare the blended porous membrane. The invention has the advantages of no toxic material in the membrane preparation process, simple membrane preparation device and process, biodegradability and convenient clinical use, and can be used for artificial skins, dressing and the like in the biomedical field.

Description

technical field [0001] The invention belongs to the field of preparation of polymer blended porous membranes, in particular to a preparation method of chitosan / polyvinyl alcohol / polylactic acid blended porous membranes. Background technique [0002] Artificial skin used to protect wounds from infection and dehydration has been widely used in the past few decades. Many polymer membranes and drug-loaded polymer membranes are used to manufacture biomaterials such as artificial skin. Chitosan is the only alkaline polysaccharide that exists in large quantities in nature. It has a wide range of sources, and it has good film-forming properties, is easy to modify, and can introduce various functional groups, making chitosan and its derivatives useful in the field of medicine. Very broad application prospects. When chitosan is used as a biological material, it has good biocompatibility, is non-toxic and has affinity to human cells, does not react with body fluids, and has no antige...

Claims

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Application Information

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IPC IPC(8): C08J5/18C08J9/28C08L5/08C08L67/04C08L29/04A61L27/26A61L27/20A61L27/18A61L27/16A61L27/56A61L27/60A61L15/28A61L15/26A61L15/24
Inventor 张瑞云姜福青潘贤林
Owner DONGHUA UNIV
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