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Method for extracting various active components from dried fructus momordicae

A technology for dried Luo Han Guo and active ingredients is applied in the field of preparation of resin separation to obtain various active ingredients in Luo Han Guo, which can solve problems such as environmental pollution and resource waste, and achieve the effects of short extraction time, reduced pressure and high yield.

Inactive Publication Date: 2010-10-06
BEIHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, we only pay attention to the extraction of mogroside, and discard the residue and other components, which will not only cause waste of resources, but also bring pollution to the environment

Method used

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  • Method for extracting various active components from dried fructus momordicae
  • Method for extracting various active components from dried fructus momordicae
  • Method for extracting various active components from dried fructus momordicae

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0119] This practice extracts multiple active ingredients from dried Luo Han Guo and includes the following steps:

[0120] The first step: flash auxiliary preparation of the first liquid mixture

[0121] Put the cored dried Luo Han Guo and deionized water into a flash extraction container, soak at a temperature of 25°C for 120 minutes, stir and break at a rotation speed of 3500r / min, and homogenize for 60s to obtain the first liquid mixture;

[0122] Dosage: Add 10g of pitted and dried Luo Han Guo to 100ml of deionized water;

[0123] Step 2: Centrifugation

[0124] Put the first liquid mixture into the centrifuge tube of the centrifuge, centrifuge at a speed of 5000r / min for 15min, then remove the centrifuge tube to obtain the first supernatant and the first precipitate;

[0125] The third step: making sweet glycosides

[0126] (3-A) Add 0.65% (mass percentage concentration) of NaCl in the first supernatant liquid, then use 25%

[0127] (mass percentage concentration) Na...

Embodiment 2

[0173] This practice extracts multiple active ingredients from dried Luo Han Guo and includes the following steps:

[0174] The first step: flash auxiliary preparation of the first liquid mixture

[0175] Put the de-pitted dried Luo Han Guo and deionized water into the extraction container, soak at a temperature of 30°C for 30 minutes, stir and break at a rotation speed of 5500r / min, and homogenize for 30s to obtain the first liquid mixture;

[0176] Dosage: Add 5g of pitted and dried Luo Han Guo to 100ml of deionized water;

[0177] Step 2: Centrifugation

[0178] Put the first liquid mixture into the centrifuge tube of the centrifuge, centrifuge at a speed of 4000r / min for 20min, then remove the centrifuge tube to obtain the first supernatant and the first precipitate;

[0179] The third step: making sweet glycosides

[0180] (3-A) in the first supernatant liquid, add the NaCl of 1% (mass percentage concentration), then adjust the pH value of the first supernatant liquid ...

Embodiment 3

[0227] This practice extracts multiple active ingredients from dried Luo Han Guo and includes the following steps:

[0228] The first step: flash auxiliary preparation of the first liquid mixture

[0229] Put the cored dried Luo Han Guo and deionized water into the extraction container, soak for 90 minutes, stir and break at a rotation speed of 4500r / min, and homogenize for 45s to obtain the first liquid mixture;

[0230] Dosage: Add 15g of de-pitted dried Luo Han Guo to 100ml of deionized water;

[0231] Step 2: Centrifugation

[0232] Put the first liquid mixture into the centrifuge tube of the centrifuge, centrifuge at a speed of 4500r / min for 10min, then remove the centrifuge tube to obtain the first supernatant and the first precipitate;

[0233] The third step: making sweet glycosides

[0234] (3-A) Add 0.5% (mass percentage concentration) of NaCl in the first supernatant liquid, then adjust the pH value of the first supernatant liquid with 25% (mass percentage concen...

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Abstract

The invention discloses a method for extracting various active components from dried fructus momordicae, which belongs to the technical field of extraction separation of the effective components of natural products. The method comprises the following steps: firstly, denucleating the dried fructus momordicae; then carrying out watering flash extraction and centrifugation on peel and pulp to obtain precipitates and a supernate; respectively carrying out XAD chromatography for two times or upper polyamide-XAD chromatography and D213 column decoloration on the supernate to obtain mogroside and polyphenol; carrying out acid solution extraction and D113 column separation on the precipitates to obtain alkaloid; carrying out concentration and ethanol fractional precipitation on waste liquid to obtain polysaccharide and oligosaccharide; and hydrolyzing waste residues by using gastric enzymes to obtain the polysaccharide, the oligosaccharide and amino acids. The invention realizes the comprehensive utilization of the medicinal materials of the fructus momordicae, reduces the production cost and increases the additional value and the economic benefit of the product by adopting an advanced extraction technology.

Description

technical field [0001] The invention relates to a separation method of natural products, more particularly, refers to a preparation method for obtaining various active components in Luo Han Guo through resin separation by adopting flash auxiliary extraction technology. Background technique [0002] Included in the "Chinese Pharmacopoeia" published in 2005, Luo Han Guo is a plant of Cucurbitaceae. Its ripe fruits are sweet in taste and cool in nature, and have the effects of clearing away heat and moistening the lungs, smoothing the intestines and laxative. Luo Han Guo is a traditional medicinal plant in my country. It has high nutritional value and is rich in sugar, protein, vitamins, fatty acids and various amino acids and trace elements. It is known as the "Oriental God Fruit". [0003] The main active ingredient in Luo Han Guo is the intensely sweet triterpenoid mogroside, which accounts for about 4% by weight of the dried fruit. It is a low-calorie natural sweetener, 3...

Claims

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Application Information

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IPC IPC(8): C07J17/00C08B37/00C07H3/06C07H1/08C12P19/00C12P19/04C12P13/00A61K36/42A61P3/10A61P3/06A61P39/06A61P37/00A61P31/00A61P29/00A61P35/00A61P31/12A61P7/02A61P1/02A61P1/16A61P3/02
Inventor 荣龙刘静刘兆刘灿杨晔王志滨荣永海
Owner BEIHANG UNIV
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