Bracket with drug temperature-sensitive controlled-release function and application thereof

A temperature-sensitive, functional technology, applied in the field of stents, to achieve good temperature sensitivity, inhibition of proliferation, and good effect of controlled drug release

Inactive Publication Date: 2013-05-01
XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no reports on stents with good temperature sensitivity and drug controlled release function.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Bracket with drug temperature-sensitive controlled-release function and application thereof
  • Bracket with drug temperature-sensitive controlled-release function and application thereof
  • Bracket with drug temperature-sensitive controlled-release function and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] 1. Preparation of amphiphilic block copolymer of thermosensitive polymer and degradable hydrophobic polymer

[0037] (1) Mix NIPAm and NHMAAm at a ratio of 7mmol: 1mmol, dissolve them in 10ml of tetrahydrofuran (THF), then add 0.04mmol of benzoyl peroxide (BPO) to the solution as an initiator, and 0.08mmol of mercaptoethanol as a chain transfer agent. agent, solution through N 2 Gas 20min;

[0038] (2) Then in N 2 Placed in a constant temperature water bath at 70°C under the protection of , and reacted with electromagnetic stirring for 7 hours;

[0039] (3) After the reaction solution is cooled, remove impurities by suction filtration;

[0040] (4) 8-10 times the volume of diethyl ether is used as a precipitating agent, after several times of dissolution, precipitation, and vacuum drying to obtain a white powder.

[0041] (5) Copolymerize the prepared methylolacrylamide and N-isopropylacrylamide with polycaprolactone (PCL) according to the ratio of 1:4 (molar ratio)...

Embodiment 2

[0051] 1. Preparation of amphiphilic block copolymer of thermosensitive polymer and degradable hydrophobic polymer

[0052] (1) Mix NIPAm and NHMAAm at a ratio of 5mmol: 1mmol, dissolve them in 10ml of tetrahydrofuran (THF), then add 0.04mmol of benzoyl peroxide (BPO) to the solution as an initiator, and 0.10mmol of mercaptoethanol as a chain transfer agent. agent, solution through N 2 Gas 20min;

[0053] (2) Then in N 2 Placed in a constant temperature water bath at 70°C under the protection of , and reacted with electromagnetic stirring for 7 hours;

[0054] (3) After the reaction solution is cooled, remove impurities by suction filtration;

[0055] (4) 8-10 times the volume of diethyl ether is used as a precipitating agent, after several times of dissolution, precipitation, and vacuum drying to obtain a white powder.

[0056] (5) Prepare the copolymer and polycaprolactone (PCL) according to the ratio of 1:6 (molar ratio), and react at 180°C for 24 hours to obtain the desi...

Embodiment 3

[0064] 1. Preparation of amphiphilic block copolymer of thermosensitive polymer and degradable hydrophobic polymer

[0065] The specific method is the same as in Example 1, wherein poly-N-isopropylacrylamide and polylactide (PLA) are proportioned according to 1:1 (molar ratio).

[0066] 2. Preparation of coatings with drug temperature-sensitive controlled release

[0067] Take by weighing 100mg polylactide (PLA) and be mixed with the organic solution that is the tetrahydrofuran of 10-15% concentration by weight percentage, take camptothecin with the medicine / polylactide ratio of 1: 20-1: 30, camptothecin Place in the above solution, mix and stir. Weigh the amphiphilic block copolymer with the amphiphilic block copolymer / polylactide ratio of 1:1-1:15, put the amphiphilic block copolymer in the above solution, mix and stir, and vortex to form a uniform mixed solution .

[0068] 3. Preparation of stents with drug temperature-sensitive controlled release

[0069] A tracheal st...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a bracket with a drug temperature-sensitive controlled-release function, which consists of a supporting bracket and a drug-carrying coating which covers the surface of the bracket, wherein the drug-carrying coating is formed by applying the coating with the drug temperature-sensitive controlled-release function on the surface of the bracket in the modes of spin coating, dip coating or spray coating. The invention also provides a coating with the drug temperature-sensitive controlled-release function and the application thereof. The coating with the drug temperature-sensitive controlled-release function has good temperature sensibility and drug controlled release function, can be evenly applied on the surface of bracket material. The drug-carrying bracket can effectively kill cancer cells and restrain the proliferation of nude mouse cancer transplantation tumor.

Description

【Technical field】 [0001] The invention relates to a bracket, in particular to a tumor therapeutic bracket with drug temperature-sensitive and controlled release and application thereof. 【Background technique】 [0002] In the field of interventional therapy, for the stenosis of blood vessels, trachea, esophagus, urethra, biliary tract and other organs, stents are usually implanted to expand the stenosis and effectively maintain the lumen. The stent is introduced into the lumen in the unexpanded state, positioned at the stenosis, expanded and placed there. Then people invented the drug-eluting stent on the basis of the stent. The drug-eluting stent is also called a drug-releasing stent, and the drug is carried by the polymer coated on the surface of the metal stent. Drug release from the polymer coating by elution. Most of the current drug-eluting stents are directly coated with hydrophobic polymers such as polylactic acid and polycaprolactone to load drugs, and this coating...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/10A61F2/82
Inventor 李松岗全志伟谭庆刚王雪峰
Owner XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap