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Maleic anhydride acidation chitosan salt/nature rubber graft copolymer and preparation method thereof

A technology of maleic anhydride acylated chitosan and acid anhydride acylated chitosan salt, applied in the field of chemical modification of natural polymers, can solve the problem that NR does not have antibacterial function and physiological activity, hydrophilicity and heat resistance Poor, no functional side groups and other problems, to achieve the effect of improved antibacterial performance, good antibacterial performance, and improved mechanical properties

Inactive Publication Date: 2010-10-20
AGRI PRODS PROCESSING RES INST CHINESE ACAD OF TROPICAL AGRI SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although NR was the first polymer material used as a medical elastomer, because NR does not have antibacterial function and physiological activity, and its hydrophilicity and heat resistance are poor; its molecular structure does not have functional side groups, and it does not have Active sites for binding to other drugs
These defects greatly limit its application in the field of medicine

Method used

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  • Maleic anhydride acidation chitosan salt/nature rubber graft copolymer and preparation method thereof
  • Maleic anhydride acidation chitosan salt/nature rubber graft copolymer and preparation method thereof

Examples

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example 1

[0045] Weigh 3 parts of chitosan, add 300 parts of water, stir magnetically, alternately add 0.5 parts of maleic anhydride and 0.5 parts of sodium carbonate every half an hour, repeat 4 times, react at room temperature for 6 hours, sodium hydroxide The pH value of the solution is adjusted to be alkaline, the unreacted chitosan is removed by filtration, and the reaction solution is dialyzed to remove small molecular impurities to prepare the MCS-Na salt solution.

[0046]Add 1 part of non-ionic surfactant Pingping plus "O" to the concentrated natural rubber latex with a dry rubber content of 100 parts to keep the latex stable; weigh 50 mL of a solution containing 20 parts of MCS-Na salt, adjust the pH value to 8, Add it dropwise to natural rubber latex under magnetic stirring conditions, then add 0.5 part of benzoyl peroxide, 0.1 part of N, N-methylenebisacrylamide, stop for 24 hours, add 0.01 part of tetraethylenepentamine, Raising the temperature to 80° C., and reacting for 2...

example 2

[0048] Dissolve 6 parts of maleic anhydride in 100 parts of DMF, add 3 parts of chitosan, N 2 Under protection, the temperature was raised to 130° C. for 2 hours, and the reaction liquid was poured into an ice-water mixture, precipitated, filtered with suction, washed several times with ether, and dried in vacuum to prepare maleic anhydride acylated chitosan (MCS); the obtained MCS is reacted with calcium hydroxide solution to prepare MCS-Ga solution.

[0049] Add 5 parts of non-ionic surfactant flat plus "O" to the concentrated natural rubber latex with dry rubber content of 100 parts to keep the latex stable; weigh 50 mL of the solution containing 30 parts of MCS-Ga, adjust the pH value to 9, and Add it dropwise to the natural rubber latex under the condition of magnetic stirring, then add 0.01 part of tert-butyl hydroperoxide, stop for 24 hours, add 0.3 part of tetraethylenepentamine, raise the temperature to 80°C, react for 10 hours, and make milk Maleic anhydride acylate...

example 3

[0051] Take by weighing 2 parts of chitosan, add 120mL of 2% (mass fraction) acetic acid solution, dissolve under stirring for 1 hour to form a homogeneous solution; take by weighing 4 parts of maleic anhydride, dissolve it in 5mL of acetone, stir Added into the reactor at room temperature for 12 hours, the product was extracted and purified with acetone, and then dried in vacuum to prepare maleic anhydride acylated chitosan (MCS); take 50 mL of the solution containing 1.0 parts of MCS, and add 0.5 parts of ZnO , Preparation of maleic anhydride acylated chitosan zinc solution.

[0052] Add 3 parts of nonionic surfactant Pingping plus "O" to the concentrated natural rubber latex with dry rubber content of 100 parts to keep the latex stable; weigh 50 mL of the solution containing 1 part of MCS-Zn, adjust the pH value to 12, and Add it dropwise to the natural rubber latex under the condition of magnetic stirring, then add 0.8 parts of cumene hydroperoxide, stop for 24 hours, add ...

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Abstract

The invention provides maleic anhydride acidation chitosan salt / nature rubber graft copolymer and a preparation method thereof. The method comprises the following steps: adding stabilizing agent non-ionic surface active agents Peregal-O into concentrated natural rubber for maintaining the stability and the temperature rise of the nature rubber; regulating the pH value of the maleic anhydride acidation chitosan salt solution between 8 and 12; then, adding obtained materials into the nature rubber; adding triggering agents of one kind or two kinds of materials in benzoyl peroxide, tert-butyl hydroperoxide, azodiisobutyronitrile, sulphur, cumene hydroperoxide, potassium peroxydisulfate and N, N-methylene-bisacrylamide; carrying out stilling standing for 24 hours; adding activating agents of tetraethylenepentamine; continuously raising the temperature; carrying out reaction for 2 to 24 hours at the temperature between 60 and 125 DEG C; and obtaining the milky maleic anhydride acidation chitosan salt / nature rubber graft copolymer. The copolymer has good antibacterial property, good physiological activity, good hydrophilcity and good heat resistance performance, and further widens the application range of the nature rubber in the fields of medical sanitation and the like.

Description

1. Technical field [0001] The invention relates to the chemical modification of natural macromolecules, in particular to a graft copolymer of natural rubber and maleic anhydride acylated chitosan (MCS) salt and a preparation method thereof. 2. Background technology [0002] Chitosan is a natural biodegradable material with good biocompatibility and non-toxicity. Studies have shown that chitosan not only has the advantages of biodegradability and low cytotoxicity, but also has a unique ability to cross cell membranes, which has attracted much attention. However, because chitosan is insoluble in water, its wider application is greatly limited. At present, water-soluble chitosan is a hotspot in the research of chitosan derivatives. MCS is a water-soluble chitosan derivative and a polymer polyelectrolyte with good water absorption. Many scholars at home and abroad have done a lot of research on its synthesis and application. Chinese patent CN98110568.8 discloses using sodium ...

Claims

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Application Information

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IPC IPC(8): C08F299/00C08B37/08
Inventor 彭政李永振罗勇悦
Owner AGRI PRODS PROCESSING RES INST CHINESE ACAD OF TROPICAL AGRI SCI
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