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Salinomycin sodium suspension as well as preparation method and application thereof

A technology of salinomycin sodium and dry suspension, applied in pharmaceutical formulations, medical preparations with inactive ingredients, medical preparations containing active ingredients, etc., can solve the problem of narrow safety range of salinomycin sodium and poor mixing effect. Ideal, uneven feed mixing, etc., to achieve the effect of improving the scope of clinical application, fast onset of drug effect, and easy storage

Active Publication Date: 2010-12-29
GUANGDONG RONGDA BIOENG CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Salinomycin sodium premix has the following disadvantages: (1) Uneven mixing with feed can easily lead to poisoning: the safety range of salinomycin sodium is relatively narrow, and the feeding concentration should be strictly controlled
Small-scale farms generally do not have mixers. Even if large-scale farms have mixers, the mixing effect is not ideal and it is difficult to mix evenly. Therefore, the local drug concentration in the feed is often too high to cause animal poisoning. For example, Jiang Miaozhao et al. (Jiang Miaozhao, Zhao Chunde. Cases of pig poisoning caused by excessive application of salinomycin [J]. Zhejiang Animal Husbandry and Veterinary Medicine, 2003, Issue 3: 35 pages) reported pig poisoning caused by uneven mixing of salinomycin sodium by operators
(2) When chickens suffer from coccidiosis, they suffer from depression, loss of appetite, and increased drinking water. However, when the salinomycin sodium premix is ​​used, it can only be mixed in the feed, so the intake of the diseased chickens will be reduced, which will affect the curative effect.
But the technology that salinomycin sodium is made into dry suspension has not been reported

Method used

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  • Salinomycin sodium suspension as well as preparation method and application thereof
  • Salinomycin sodium suspension as well as preparation method and application thereof
  • Salinomycin sodium suspension as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Salinomycin Sodium 2g

[0048] Sucrose 90g

[0049] Sodium saccharin 5g

[0050] Methylcellulose 2g

[0051] Glycerin 1g

[0052] The preparation method is as follows:

[0053] (1) accurately weigh the salinomycin sodium of prescription quantity and cross 80 mesh sieves;

[0054](2) Accurately weigh the sucrose, sodium saccharin, and methylcellulose of the prescribed amount respectively, pass through an 80-mesh sieve respectively, and mix uniformly in equal increments;

[0055] (3) Steps (1) and (2) are mixed in equal increments to obtain mixed powder;

[0056] (4) Add 1g of glycerin to the mixed powder to make a soft material, and pass through a 40-mesh sieve;

[0057] (5) Dry at 60°C-80°C, granulate with a 40-mesh sieve;

[0058] (6) After passing the intermediate inspection, the finished product can be obtained by sub-packaging.

Embodiment 2

[0060] Salinomycin Sodium 30g

[0061] Mannose 20g

[0062] Cyclamate 40g

[0063] Hydroxypropyl Methyl Cellulose 20g

[0064] 50 volume% ethanol 30g

[0065] The preparation method is as follows:

[0066] (1) accurately weigh the salinomycin sodium of prescription quantity and cross 120 mesh sieves;

[0067] (2) Accurately weigh the mannose, cyclamate, and hydroxypropyl methylcellulose of the prescription amount respectively, pass through a 120 mesh sieve respectively, and mix uniformly in equal increments;

[0068] (3) Steps (1) and (2) are mixed in equal increments to obtain mixed powder;

[0069] (4) Add 50% ethanol 30g to the mixed powder to make a soft material, and pass through a 30-mesh sieve;

[0070] (5) Dry at 60°C-80°C, and granulate with a 30-mesh sieve;

[0071] (6) After passing the intermediate inspection, the finished product can be obtained by sub-packaging.

Embodiment 3

[0073] Salinomycin Sodium 6g

[0074] Sorbitol 70g

[0075] Acesulfame Potassium 10g

[0076] Polyvinylpyrrolidone 15g

[0077] Propylene glycol 2g

[0078] The preparation method is as follows:

[0079] (1) accurately weigh the salinomycin sodium of prescription quantity and cross 100 mesh sieves;

[0080] (2) Accurately weigh sorbitol, acesulfame potassium, and polyvinylpyrrolidone of the prescribed amount respectively, pass through a 100-mesh sieve respectively, and mix uniformly in equal increments;

[0081] (3) Steps (1) and (2) are mixed in equal increments to obtain mixed powder;

[0082] (4) Add 2 g of propylene glycol to the mixed powder to make a soft material, and pass through a 35-mesh sieve;

[0083] (5) Dry at 60°C-80°C, granulate with a 35-mesh sieve;

[0084] (6) After passing the intermediate inspection, the finished product can be obtained by sub-packaging.

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Abstract

The invention discloses a salinomycin sodium suspension as well as a preparation method and an application thereof. The salinomycin sodium suspension comprises the following components in parts by weight: 2-30 parts of salinomycin sodium, 20-90 parts of filler, 5-40 parts of flavoring agent, 2-20 parts of suspending agent and 1-30 parts of wetting agent. The preparation method of the salinomycin sodium suspension comprises the following steps: sieving and mixing all raw materials, adding the wetting agent to prepare soft material, drying and pelletizing to obtain the product in the invention. The salinomycin sodium suspension in the invention has evenly distributed particles, high bioavailability, rapid drug response, simple preparation process and wide application prospect, and can become a liquid preparation after water is added.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, and in particular relates to a dry suspension of salinomycin sodium and its preparation method and application. Background technique [0002] Coccidiosis is a disease caused by a single-cell parasite of the genus Eimeria, which seriously endangers the growth and development of poultry and causes serious environmental pollution. These parasites multiply in the intestinal epithelial cells, destroy the integrity of the intestinal mucosa, and reduce the digestion and absorption capacity of the intestine. There are 7 kinds of coccidia that can infect chickens in my country, namely Eimeria tenacia, Eimeria poisonous, Eimeria pileus, Eimeria giant, and Eimeria hastensi Eimeria, Eimeria modera, and Eimeria precoccus. Eimeria tenella and Eimeria venom are the most pathogenic, often causing outbreaks of coccidiosis in chickens, and the rest are weakened in turn. The disease has the following characteri...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/351A61K47/38A61P33/02A61P43/00
Inventor 黄炜乾方文棋刘元江莫细好禤雪军程艳杨亚勇
Owner GUANGDONG RONGDA BIOENG CO LTD
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