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Applications of human placenta peptide in preparing drugs for treating dry eye syndrome and other ocular surface diseases

A technology for human placenta and dry eye, applied in sensory diseases, drug combinations, pharmaceutical formulations, etc., can solve problems such as affecting people's vision and quality of life, low curative effect, and difficult treatment.

Inactive Publication Date: 2012-08-15
ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Dry eye, also known as dry eye syndrome, is a common chronic ophthalmic disease that can lead to erosion and inflammation of the conjunctiva and corneal epithelium. It is difficult to treat and is difficult to cure, seriously affecting people's vision and quality of life
Topical application of artificial tears and growth factors is the main method for the treatment of dry eye. Commonly used eye drops are: sodium hyaluronate eye drops, hydroxypropyl methylcellulose eye drops, methylcellulose eye drops , polyvinyl alcohol eye drops, polyacrylic acid eye drops, dextran-70 eye drops, epidermal growth factor eye drops, basic fibroblast growth factor eye drops, Sugaojie eye gel, etc. Eye drops (or gel) have a certain auxiliary effect on promoting the healing of corneal and conjunctival epithelial injuries, lubricating the ocular surface, and treating ocular surface diseases such as dry eye, but the curative effect is not high

Method used

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  • Applications of human placenta peptide in preparing drugs for treating dry eye syndrome and other ocular surface diseases
  • Applications of human placenta peptide in preparing drugs for treating dry eye syndrome and other ocular surface diseases
  • Applications of human placenta peptide in preparing drugs for treating dry eye syndrome and other ocular surface diseases

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Experimental program
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preparation example Construction

[0071] 1. Preparation of human placenta peptide stock solution:

[0072] Select healthy maternal placentas with negative prenatal serological tests for HIV, hepatitis B virus, hepatitis C virus, and syphilis. The placentas of mothers suffering from infectious hepatitis, AIDS, syphilis and other diseases, as well as the placentas of induced abortion, stillbirth, and various deformed children are not used. Immediately after delivery of the placenta, put it on ice under aseptic conditions and bring it back quickly. The placenta can also be refrigerated below -10°C, and it should also be refrigerated during collection and transportation. If the frozen placenta is below -30°C, it should be stored at 3 Applied within one month. The umbilical cord blood of the placenta is taken for HIV, hepatitis B virus, hepatitis C virus, syphilis and other tests, and the placenta with negative above indicators can be selected for application.

[0073] According to the aseptic standard of cell cu...

Embodiment 1、50

[0077] The preparation of embodiment 1,50% (volume fraction) human placenta peptide eye drops

[0078] Human placenta peptide stock solution 500ml

[0079] Sodium chloride 4g

[0080] 1mol / L sodium hydroxide appropriate amount

[0081] Add water for injection to 1000ml

[0082] Take 4g of sodium chloride and add an appropriate amount of water for injection to dissolve it, stir well, adjust the pH value to 7.2±0.2 with 1mol / L sodium hydroxide, then add 500ml of human placental peptide stock solution, and then add water for injection to 1000ml, and pass through the aperture Sterilize by filtering through a 0.2μm filter membrane, and pack aseptically, 0.5ml per tube.

[0083] 2. Preparation of thickened human placenta peptide eye drops

Embodiment 2、25

[0084] Embodiment 2, preparation of 25% (volume fraction) human placenta peptide stock solution+0.1% (mass fraction) sodium hyaluronate eye drops

[0085] Human placenta peptide stock solution 250ml

[0086] Sodium chloride 6.0g

[0087] Sodium Hyaluronate 1g

[0088] 1mol / L sodium hydroxide appropriate amount

[0089] Add water for injection to 1000ml

[0090] Take 6.0g of sodium chloride, add appropriate amount of water for injection and dissolve it, stir well, adjust the pH value to 7.2±0.2 with 1mol / L sodium hydroxide, then add 1g of sodium hyaluronate, soak to make it swell, stir and mix well, Sterilize under high temperature and high pressure for 30 minutes, cool down, make up to 750ml with sterile water for injection, add 250ml of human placenta peptide stock solution under aseptic conditions, mix well, and aseptically dispense, 0.5ml per tube.

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Abstract

The invention discloses applications of human placenta peptide in preparing drugs for treating simple keratitis, dry eye syndrome, corneal epithelium erosion, corneal alkali burn, various keratititides, LASIK corneal laser surgery and other ocular surface diseases. The experiment proves that the human placenta peptide can increase the tear liquid secretion amount of a dry eye model of New Zealandwhite rabbits, promote the repairation of corneal epithelium cell damage, increase the quantity of conjunctiva goblet cells, has no stimulation to eyes, and has therapeutic effect on the dry eye model of the New Zealand white rabbit with obvious curative effect, thus the human placenta peptide can be used for treating the dry eye syndrome, the corneal epithelium erosion, corneal epithelium defect, the corneal alkali burn, keratitis and the LASIK corneal laser surgery and the other ocular surface diseases.

Description

Technical field: [0001] The invention belongs to the field of medicines, and specifically relates to the application of human placenta peptides in the preparation of medicines for treating ocular surface diseases such as dry eye, corneal epithelial erosion, corneal epithelial defect, corneal alkali burn, keratitis, and LASIK corneal laser surgery. Background technique: [0002] Dry eye, also known as dry eye syndrome, is a common chronic ophthalmic disease that can lead to erosion and inflammation of the conjunctiva and corneal epithelium. Treatment is difficult and difficult to cure, seriously affecting people's vision and quality of life. Topical application of artificial tears and growth factors is the main method for the treatment of dry eye. Commonly used eye drops are: sodium hyaluronate eye drops, hydroxypropyl methylcellulose eye drops, methylcellulose eye drops , polyvinyl alcohol eye drops, polyacrylic acid eye drops, dextran-70 eye drops, epidermal growth factor e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/02A61K35/50A61P27/02
Inventor 邓新国高杨孙倩娜何梅风李娜
Owner ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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