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Polrvinyl chloride (PVC) tube composition for medicine and preparation method thereof

A technology of polyvinyl chloride and polyvinyl chloride paste, applied in catheters and other directions, can solve problems affecting human health, etc., and achieve the effect of easy processing and molding, and good biocompatibility

Inactive Publication Date: 2011-01-26
NINGBO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, citric acid esters are still easy to migrate and precipitate and mix into the liquid medicine or blood, and can enter the human body with the liquid medicine or blood, seriously affecting human health

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A polyvinyl chloride medical tubing composition, each raw material component and mass ratio are as follows:

[0028] Polyvinyl chloride (PVC) vinyl paste resin 80 parts

[0029] Epoxidized soybean oil 25 parts

[0030] Normal temperature ionic liquid [bmim]PF 6 5 copies

[0031] CaCO 3 5 copies

[0032] Ca / Zn stabilizer 2 parts

[0033] Diluent 0.5 parts.

[0034] The diluent is a mixture of n-hexane, xylene, butyl acetate and sodium diacetate, and the mixing ratio is 1:1:0.5:0.5 by mass.

[0035] Its preparation process is as follows:

[0036] Stir the above polyvinyl chloride, epoxy soybean oil, normal temperature ionic liquid and diluent in a stirred tank at 40°C for 5 minutes, and after cooling to normal temperature, add 5 parts of CaCO 3 , 2 parts of Ca / Zn stabilizer, continue to stir for 5 minutes.

Embodiment 2

[0038] A polyvinyl chloride medical tubing composition, each raw material component and mass ratio are as follows:

[0039] 90 parts of polyvinyl chloride paste resin

[0040] 30 parts of tri-n-butyl citrate

[0041] Normal temperature ionic liquid [hmim]PF 6 20 copies

[0042] CaCO 3 7 copies

[0043] Ca / Zn stabilizer 3 parts

[0044] Thinner 1 part.

[0045] The diluent is a mixture of n-hexane, xylene, butyl acetate and sodium diacetate, and the mixing ratio is 1:1.5:1:1 by mass.

[0046] Its preparation process is as follows:

[0047] The above polyvinyl chloride, tri-n-butyl citrate, normal temperature ionic liquid [hmim]PF 6 , The diluent was stirred in a stirred tank at 60°C for 15 minutes, and after cooling to room temperature, 7 parts of CaCO were added 3 , 3 parts of Ca / Zn stabilizer, continue stirring for 7 minutes.

Embodiment 3

[0049] A polyvinyl chloride medical tubing composition, each raw material component and mass ratio are as follows:

[0050] 100 parts polyvinyl chloride paste resin

[0051] Acetyl tri-n-butyl citrate 40 parts

[0052] Normal temperature ionic liquid [omim]PF 6 40 copies

[0053] CaCO 3 10 copies

[0054] Ca / Zn stabilizer 5 parts

[0055] Thinner 2 parts.

[0056] The diluent is a mixture of n-hexane, xylene, butyl acetate and sodium diacetate, and the mixing ratio is 1:2:2:1 by mass.

[0057] Its preparation process is as follows:

[0058] The above polyvinyl chloride, acetyl tri-n-butyl citrate, normal temperature ionic liquid [omim]PF 6 , The diluent was stirred in a stirred tank at 80°C for 20 minutes, and after cooling to room temperature, 10 parts of CaCO 3 , 5 parts of Ca / Zn stabilizer, continue stirring for 10 minutes.

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Abstract

The invention discloses a polrvinyl chloride (PVC) tube composition for medicine and a preparation method thereof. The composition comprises the following components in parts by weight: 80 to 100 parts of PVC paste resin, 25 to 40 parts of plasticizer, 5 to 40 parts of room-temperature ionic liquid, 5 to 10 parts of CaCO3, 2 to 5 parts of Ca / Zn stabilizer and 0.5 to 2 parts of diluent. The preparation method comprises the following steps: stirring the 80 to 100 parts of the PVC paste resin, 25 to 40 parts of the plasticizer, 5 to 40 parts of the room-temperature ionic liquid and 0.5 to 2 parts of the diluent at the temperature of 40 to 80 DEG C for 5 to 25min; and cooling the mixture to the normal temperature, adding 5 to 10 parts of the CaCO3 and 2 to 5 parts of the Ca / Zn stabilizer to the mixture and continuing stirring for 5 to 10min to obtain the PVC tube composition for medicine. The raw materials of the synthesized medical tube of the invention have high thermal stability, mechanical property, durability, biocompatibility and the like and are suitable for producing various medical catheters and easy to process and mould.

Description

technical field [0001] The invention relates to the technical field of polymer materials, in particular to a modified polyvinyl chloride, in particular to a normal-temperature ionic liquid plasticized polyvinyl chloride medical pipe composition and a preparation method thereof. Background technique [0002] With the development of catheter diagnosis and treatment technology, the clinical application of medical catheters is developing day by day, the demand is increasing, and the requirements for catheters are getting higher and higher. Therefore, the development of a raw material for medical catheters with good thermal stability, good mechanical properties, good durability and good biocompatibility is increasingly favored by the industry. At present, domestic medical catheters are generally made of polyvinyl chloride, but citric acid esters are still used as the main plasticizer in the process of polyvinyl chloride. However, citric acid esters are still easy to migrate and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L27/06C08K13/02C08K3/26C08K5/52C08K5/42C08K5/3445A61L29/04A61L29/02A61L29/14
Inventor 周正盈侯琳熙刘燕王文群
Owner NINGBO UNIV
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