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Cardiovascular stent coating material with endothelial cell selectivity and preparation and application method thereof

A technology of endothelial cells and coating materials, applied in coating, medical science, surgery, etc., can solve the problems of destroying the healing of endothelial layer, increasing the death of late thrombus, and achieving the effects of wide application range, growth inhibition, and good reactivity

Active Publication Date: 2011-02-02
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, while the drug inhibits smooth muscle cells, it also inhibits the growth of endothelial cells, thereby disrupting the healing of the endothelial layer, increasing the risk of late thrombosis and even death

Method used

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  • Cardiovascular stent coating material with endothelial cell selectivity and preparation and application method thereof
  • Cardiovascular stent coating material with endothelial cell selectivity and preparation and application method thereof
  • Cardiovascular stent coating material with endothelial cell selectivity and preparation and application method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] (1) Synthetic terpolymer

[0041] In a 50 mL polymerization tube, add 0.8 g MPC, 2.5 g SMA, 1.0 g MEONP (n=6) and 0.086 g initiator AIBN, and dissolve them with 30 ml ethanol. Freeze with liquid nitrogen until solid, vacuumize for 10 minutes, and then blow in argon; repeat the above steps three times to remove oxygen. Seal the tube with an alcohol blowtorch, put it in a 60°C oil bath and stir for 24 hours. After the reaction was completed, the polymerization tube was broken open, the polymerization solution was transferred to a 100ml single-necked flask, the solvent was removed by rotary evaporation under reduced pressure, and then precipitated with ice methanol. A light yellow solid was obtained by suction filtration, which was dissolved in tetrahydrofuran again, and the steps of rotary evaporation, precipitation and suction filtration were repeated three times. Finally, a light yellow solid was obtained, which was dried in a vacuum oven. NMR results confirmed that ...

Embodiment 2

[0055] (1) Synthetic terpolymer:

[0056] In a 50 mL polymerization tube, 0.6 g of MPC, 0.8 ml of BMA, 1.8 g of MEONP (n=10) and 0.067 g of initiator AIBN were added and dissolved in 10 ml of tetrahydrofuran. Freeze with liquid nitrogen until it is solid, vacuumize for 30 minutes, and then blow in nitrogen; repeat the above steps three times to remove oxygen. Seal the tube with an alcohol blowtorch, put it in a 90°C oil bath and stir for 48 hours. After the reaction was completed, the polymerization tube was broken open, the polymerization solution was transferred to a 100ml single-necked flask, the solvent was removed by rotary evaporation under reduced pressure, and then precipitated with ice methanol. A light yellow solid was obtained by suction filtration, which was dissolved in tetrahydrofuran again, and the steps of rotary evaporation, precipitation and suction filtration were repeated three times. Finally, a light yellow solid was obtained, which was dried in a vacuum...

Embodiment 3

[0070] (1) Synthetic terpolymer:

[0071] In a 50 mL polymerization tube, add 0.72 g PEGMA (n=6), 1.5 ml BMA, 1.2 g MEONP (n=1) and 0.05 g initiator AIBN, and dissolve with 50 ml isopropanol. Freeze with liquid nitrogen until solid, vacuumize for 30 minutes, and then blow in argon; repeat the above steps three times to remove oxygen. Seal the tube with an alcohol blowtorch, put it in a 65°C oil bath and stir for 20 hours. After the reaction was completed, the polymerization tube was broken open, the polymerization solution was transferred to a 100ml single-necked flask, the solvent was removed by rotary evaporation under reduced pressure, and then precipitated with ice methanol. A light yellow solid was obtained by suction filtration, which was dissolved in tetrahydrofuran again, and the steps of rotary evaporation, precipitation and suction filtration were repeated twice. Finally, a light yellow solid was obtained, which was dried in a vacuum oven. NMR results confirmed th...

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Abstract

The invention discloses a cardiovascular stent coating material with endothelial cell selectivity and a preparation and application method thereof. The coating material is copolymerized by three monomers via free radicals, wherein the three monomers are as follows: a biocompatibility monomer containing cell membrane bionic structure, a polymerizable monomer containing hydrophobic functional groups and a polymerizable monomer containing reactive activity functional groups; the three monomers are synthesized into a terpolymer with reactive activity with a free radical copolymerization method; polypeptide sequence arginine-glutamic acid-aspartic acid-valine can be introduced in with a surface fixing method, and can specifically accelerate the adherency of endothelial cells to cause the coating to have endothelial cell selectivity. The cardiovascular stent coating material has good reactivity, can realize the immobilization and activity maintenance of biomolecules, such as polypeptide andthe like, and realizes the capture capability of in vivo in situ endothelial cells; and in addition, the obtained coating has stable structure, can adapt to the internal environment of human bodies and has good application prospect on cardiovascular diseases, cancers and the like.

Description

technical field [0001] The invention relates to a cardiovascular stent coating material with endothelial cell selectivity and its preparation and application method, and belongs to the interdisciplinary field of materials, biology, physics, chemistry and other disciplines. Background technique [0002] The application of new cardiovascular implant materials has become an important means for people to overcome cardiovascular diseases. However, the existing cardiovascular medical materials still have a series of problems including blood coagulation and postoperative stenosis. In order to solve this critical problem, a series of attempts have been made. Carrying drugs on the stent to inhibit cells to solve the problem of postoperative stenosis is a commonly used method at present. However, while the drug inhibits smooth muscle cells, it also inhibits the growth of endothelial cells, thereby destroying the healing of the endothelial layer, increasing the risk of late thrombosis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/14C08F230/02C08F220/28C08F220/38C08F222/22C08F220/18C08F290/06A61L31/10
Inventor 计剑徐建平魏雨纪缨
Owner ZHEJIANG UNIV
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