Method for preparing and refining 1,3-propanedisulfonate

A kind of technology of sodium propanedisulfonate and purification method, which is applied in the field of preparation and purification of 1,3-sodium propanedisulfonate, and achieves the effects of low cost, high yield and short reaction time
CN102001973AInactive Publication Date: 2011-04-06NINGBO INST OF TECH ZHEJIANG UNIV ZHEJIANG
5 Cites 5 Cited by

Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Applications(China)
Current Assignee / Owner
NINGBO INST OF TECH ZHEJIANG UNIV ZHEJIANG
Publication Date
2011-04-06
Estimated Expiration
Not applicable ยท inactive patent

Smart Images

  • Figure 1
    Figure 1
Patent Text Reader

Abstract

The invention relates to a method for preparing and refining 1,3-propanedisulfonate and aims to solve technical problems of raw material cost reduction, stability, process simplification and product yield improvement. The preparation method is to react 1,3-dichloropropane and sodium sulfite in a reaction solvent to obtain coarse 1,3-propanedisulfonate, wherein the mole ratio of the 1,3-dichloropropane to the sodium sulfite is 1:1-4. The refining method is to dissolve the coarse 1,3-propanedisulfonate in water, add crystallizing agent, namely an organic solvent which can be mixed with water, to obtain 1,3-propanedisulfonate, wherein the amount of water is 2 to 20 times the weight of the coarse 1,3-propanedisulfonate.
Need to check novelty before this filing date? Find Prior Art

Description

[0001] technical field

[0002] The invention relates to the field of pharmaceutical chemical synthesis, in particular to a method for preparing and refining sodium 1,3-propanedisulfonate. Background of the invention

[0003] US Patent US5643562 discloses that 1,3-propanedisulfonate can be used to treat amyloidosis, and world patent WO2007125385 discloses that 1,3-propanedisulfonate can also be used to treat nephropathy, diabetic nephropathy and dyslipidemia. In fact, abroad, sodium 1,3-propanedisulfonate has entered phase III clinical trials for the treatment of amyloidosis, and phase II clinical trials for the treatment of diabetes. Will be available for sale soon.

[0004] The synthesis of 1,3-propanedisulfonate sodium was reported as early as the 1930s, and the literature [J.Am.Chem.Soc.1936; 58: 488-9] synthesized 1,3-propanedisulfonate sodium is to react 1,3-dibromopropane with sodium sulfite:

[0005]

[0006] Repeated treatment with lead acetate, silver nitrate...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More