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Application of peperphentonamine or salt thereof in preparing drug for preventing/treating encephalopathy

The technology of piperphentonamine salt and piperphentonamine is applied in the field of use of piperphentonamine or its salt in the preparation of medicines for preventing/treating encephalopathy, and can solve the problem that the curative effect of patients with craniocerebral trauma lacks first-level clinical evidence-based Medical evidence and other issues to achieve good therapeutic effect, stable yield, and low toxicity

Active Publication Date: 2011-04-27
WUXI JIYU SHANHE PHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the lack of first-level clinical evidence-based medical evidence for the efficacy of various peptide neurotrophic drugs in the treatment of patients with traumatic brain injury, it is recommended to use them with caution

Method used

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  • Application of peperphentonamine or salt thereof in preparing drug for preventing/treating encephalopathy
  • Application of peperphentonamine or salt thereof in preparing drug for preventing/treating encephalopathy
  • Application of peperphentonamine or salt thereof in preparing drug for preventing/treating encephalopathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Preventive and therapeutic effects of piperphentonamine and piperphentonamine hydrochloride on cultured brain neuron injury.

[0046] 1. Experimental animals: 18 ordinary Sprague Dawley rats, weighing 250g-280g. Polylysine is a product of Sigma; DMEM medium is a product of Gibco; other reagents are of analytical grade.

[0047] 2. Primary culture of nerve cells

[0048] Pregnant rats were anesthetized with chloral hydrate on day 15, sterilized the chest and abdomen with 75% ethanol, took out the fetal rats under aseptic conditions, peeled off, separated the cortical tissues on both sides, cut them into minces with a scalpel, and transferred them into phosphoric acid containing 0.125% trypsin Digest in the buffer solution for 30min (37°C), discard the digestion solution, add DMED culture solution containing 10% fetal bovine serum, 10% horse serum, 100U / ml penicillin, 100U / ml streptomycin, blow repeatedly with a small-bore pipette Disperse, filter through a 200-mesh cel...

experiment example 2

[0060] Therapeutic effects of piperphentonamine and piperphentonamine hydrochloride on mice with blunt traumatic brain injury.

[0061] The automatic recorder for the jumping experiment was from the Instrument and Electricity Department of the Institute of Materia Medica, Chinese Academy of Medical Sciences; the fluorescence spectrophotometer was from HITACHI Corporation of Japan; and the microplate reader.

[0062] Experimental animals: clean grade Kunming mice, weighing 20g-22g.

[0063] Get 70 mice, are randomly divided into normal control group, model group, 2mg / kg piperphentonamine (dilution to appropriate concentration with 5% glucose injection when used, the same below) group, piperphentonamine hydrochloride 1mg / kg group , 2mg / kg group, 4mg / kg group and 4mg / kgATP group, 10 rats in each group.

[0064] After fasting for 16 hours, a mouse model of closed traumatic brain injury was established. Each group was administered intravenously. After 24 hours, the brains of the m...

Embodiment 3

[0070] Neuroprotective therapeutic effect of piperphentonamine hydrochloride in mice with vascular dementia.

[0071] Piperphentonamine hydrochloride: Dilute to an appropriate concentration with 5% glucose injection when used. The automatic recorder for the jumping experiment is a product of the Instrument and Electricity Laboratory of the Institute of Materia Medica, Chinese Academy of Medical Sciences; the fluorescence spectrophotometer is a product of HITACHI Japan; the microplate reader.

[0072] Experimental animals: clean grade Kunming mice, weighing 20g-22g.

[0073] 1. Improvement effect of piperphentonamine hydrochloride on learning and memory dysfunction in cerebral ischemia-reperfusion mice

[0074] Animals were randomly divided into sham operation group, model group, piperphentonamine hydrochloride 1mg / kg group, 2mg / kg group, 4mg / kg group, 10 in each group.

[0075] After fasting for 16 hours, the mouse model of dementia caused by ischemia-reperfusion was establi...

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Abstract

The invention relates to application of peperphentonamine or a pharmaceutically acceptable salt thereof in preparing a drug for preventing / treating mammal encephalopathy, the encephalopathy comprises a brain injury disease or a cranial vascular disease, and the mammal includes a human being. The peperphentonamine or the salt thereof is a compound which has good treatment effect, low toxic or side effect and superior curative effect than traditional drugs for treating the encephalopathy, and probably becomes a novel drug for the brain injury and the cranial vascular disease treatment as well as the cerebral ischemia antagonism and injury reperfusion.

Description

technical field [0001] The present invention relates to the application of piperphentonamine or its salt in the preparation of drugs for the prevention / treatment of mammals including human encephalopathy, in particular to the application of piperphentonamine and its salt in the preparation of prevention / treatment of cerebral ischemia, ischemia / reperfusion Injury or cerebral hemorrhage and application of brain injury drugs. Background technique [0002] Encephalopathy (encephalopathy) refers to any organic brain damage, which is caused by genetic, congenital brain hypoplasia, brain trauma, brain tumor, cerebral hemorrhage, cerebral infarction, infection, chemical drug poisoning, etc. A large group of diseases with symptoms and signs such as mental retardation, thinking, language barriers, paresthesia, limb paralysis and even incontinence. Common encephalopathy can be divided into three categories: one is children with cerebral palsy and mental retardation caused by heredity ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/36A61P25/00A61P9/00A61P9/10
CPCA61K31/36A61K31/357A61P9/00A61P9/10A61P9/14A61P25/00A61P43/00
Inventor 万华印李茹冰周力践刘铁球陈阳述李永贺
Owner WUXI JIYU SHANHE PHARM CO LTD
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