Metronidazole, clotrimazole and chlorhexidine acetate vagina gel and preparation method thereof

Abstract

The invention discloses a metronidazole, clotrimazole and chlorhexidine acetate vagina gel and a preparation method thereof. Every 1000g of gel comprises the following components by weight: 40g of metronidazole, 32g of clotrimazole, 1.6g of chlorhexidine acetate, 10g of Carbomer 934, 120g of glycerol, 4g of triethanolamine, 1g of ethylparaben and the balance pure water. The method comprises the following steps: (1) mixing the metronidazole, clotrimazole and chlorhexidine acetate based on respective weight, and crushing evenly and sieving for later use; (2) preparing the Carbomer 934, triethanolamine and pure water into a matrix based on respective weight; (3) adding glycerol, ethylparaben into the crushed components in the step (1), and stirring evenly to obtain a mixture for later use; (4) adding pure water into the mixture of the step (3), mixing evenly to prepare into 1000g of gel; and (5) carrying out encapsulation on the gel obtained in the step (4) to obtain the product of the metronidazole, clotrimazole and chlorhexidine acetate vagina gel. The metronidazole, clotrimazole and chlorhexidine acetate vagina gel disclosed by the invention has excellent treating effects, and is a medicine which is convenient to use, is non-irritant, and has no foreign body sensation and good curative effect.

Description

technical field [0001] The invention relates to medicines, and is a bizoate vaginal gel and a preparation method thereof. Background technique [0002] Shuangzotai is a commonly used over-the-counter drug for the treatment of gynecological vaginitis. is currently widely used. The patented formulations include effervescent tablets, suppositories, and ointments. These preparations all have respective different advantages and efficacy in use. Since metronidazole, clotrimazole and chlorhexidine acetate in Shuangzotai have different effects on different types of vaginal inflammations, the synergistic effect of the combination of the three drugs is mainly used. These medicaments that this area uses all are to treat vaginitis, and vaginitis is divided into many kinds: trichomonas vaginitis, bacterial vaginitis, mycotic vaginitis, mixed vaginitis etc., these inflammations again with mixed vaginitis Vaginitis is the most difficult to eradicate, and the recurrence rate is extremel...

AI Technical Summary

Problems solved by technology

These medicaments that this area uses all are to treat vaginitis, and vaginitis is divided into many kinds: trichomonas vaginitis, bacterial vaginitis, mycotic vaginitis, mixed vaginitis etc., these inflammations again with mixed vaginitis Vaginitis is the most difficult to eradicate, and the recurrence rate is extremely high. The use effect of these dosage forms shows that Shuangzotai has a poor therapeutic effect on mixed vaginitis. According to the analysis of the feedback from the use, the main reason is that effervescent tablets need to absorb water It can disintegrate, and there is a burning sensation for patients with vaginal dryness; suppositories need to be melted by body temperature, and the onset of action is sl

Images