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Metronidazole, clotrimazole and chlorhexidine acetate vagina gel and preparation method thereof

A technology of vaginal gel and bizoate, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. It can solve the problem of small mucosal contact surface, difficult eradication, burning sensation in patients, etc. problem, to achieve the effect of high cure rate, good bioadhesion, and good therapeutic effect

Active Publication Date: 2012-05-23
济南博利医药生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These medicaments that this area uses all are to treat vaginitis, and vaginitis is divided into many kinds: trichomonas vaginitis, bacterial vaginitis, mycotic vaginitis, mixed vaginitis etc., these inflammations again with mixed vaginitis Vaginitis is the most difficult to eradicate, and the recurrence rate is extremely high. The use effect of these dosage forms shows that Shuangzotai has a poor therapeutic effect on mixed vaginitis. According to the analysis of the feedback from the use, the main reason is that effervescent tablets need to absorb water It can disintegrate, and there is a burning sensation for patients with vaginal dryness; suppositories need to be melted by body temperature, and the onset of action is slow; and the disintegration or melting of suppositories and effervescent tablets has a short residence time, and the drug absorption effect is poor, so it is not suitable for repeated attacks. The curative effect of vaginitis is not good; the ointment is an oily base, which affects the normal function of the skin and mucous membrane, and the contact surface with the mucous membrane is small, and the effective residence time in the vagina is short, thus affecting the curative effect
Due to the short residence time of the drug in the vagina, the existing dosage form has a good curative effect on the bacteria on the surface of the mucosa, but has a minimal effect on the pathogens that have invaded the submucosa. Poor efficacy in

Method used

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  • Metronidazole, clotrimazole and chlorhexidine acetate vagina gel and preparation method thereof
  • Metronidazole, clotrimazole and chlorhexidine acetate vagina gel and preparation method thereof

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Embodiment

[0017] A kind of Shuangzotai vaginal gel of the present invention, every 1000g gel is made up of the following components by weight ratio: metronidazole 40g, clotrimazole 32g, chlorhexidine acetate 1.6g, carbomer 934 10g , glycerin 120g, triethanolamine 4g, ethylparaben 1g, and the rest is purified water.

[0018] The preparation method of a kind of Shuangzotai vaginal gel of the present invention is made according to the following steps:

[0019] ①Prepare 1000g of gel, take 40g of metronidazole, 32g of clotrimazole, and 1.6g of chlorhexidine acetate according to the weight ratio, mix them and pulverize them, pass through a 100-mesh sieve for later use;

[0020] ② Take 10g of Carbomer 934, 4g of triethanolamine and purified water according to the weight ratio; sprinkle Carbomer 934 evenly on the surface of purified water, let it sit for 40-48 hours to fully swell naturally, then add triethanolamine and stir evenly, and adjust the pH to 5- 6, make the matrix;

[0021] 3. Add ...

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PUM

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Abstract

The invention discloses a metronidazole, clotrimazole and chlorhexidine acetate vagina gel and a preparation method thereof. Every 1000g of gel comprises the following components by weight: 40g of metronidazole, 32g of clotrimazole, 1.6g of chlorhexidine acetate, 10g of Carbomer 934, 120g of glycerol, 4g of triethanolamine, 1g of ethylparaben and the balance pure water. The method comprises the following steps: (1) mixing the metronidazole, clotrimazole and chlorhexidine acetate based on respective weight, and crushing evenly and sieving for later use; (2) preparing the Carbomer 934, triethanolamine and pure water into a matrix based on respective weight; (3) adding glycerol, ethylparaben into the crushed components in the step (1), and stirring evenly to obtain a mixture for later use; (4) adding pure water into the mixture of the step (3), mixing evenly to prepare into 1000g of gel; and (5) carrying out encapsulation on the gel obtained in the step (4) to obtain the product of the metronidazole, clotrimazole and chlorhexidine acetate vagina gel. The metronidazole, clotrimazole and chlorhexidine acetate vagina gel disclosed by the invention has excellent treating effects, and is a medicine which is convenient to use, is non-irritant, and has no foreign body sensation and good curative effect.

Description

technical field [0001] The invention relates to medicines, and is a bizoate vaginal gel and a preparation method thereof. Background technique [0002] Shuangzotai is a commonly used over-the-counter drug for the treatment of gynecological vaginitis. is currently widely used. The patented formulations include effervescent tablets, suppositories, and ointments. These preparations all have respective different advantages and efficacy in use. Since metronidazole, clotrimazole and chlorhexidine acetate in Shuangzotai have different effects on different types of vaginal inflammations, the synergistic effect of the combination of the three drugs is mainly used. These medicaments that this area uses all are to treat vaginitis, and vaginitis is divided into many kinds: trichomonas vaginitis, bacterial vaginitis, mycotic vaginitis, mixed vaginitis etc., these inflammations again with mixed vaginitis Vaginitis is the most difficult to eradicate, and the recurrence rate is extremel...

Claims

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Application Information

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IPC IPC(8): A61K31/4174A61K31/4164A61K31/155A61K9/00A61K47/32A61K47/18A61P15/02
Inventor 沈文立
Owner 济南博利医药生物工程有限公司
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