Metronidazole, clotrimazole and chlorhexidine acetate vagina gel and preparation method thereof
A technology of vaginal gel and bizoate, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. It can solve the problem of small mucosal contact surface, difficult eradication, burning sensation in patients, etc. problem, to achieve the effect of high cure rate, good bioadhesion, and good therapeutic effect
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[0017] A kind of Shuangzotai vaginal gel of the present invention, every 1000g gel is made up of the following components by weight ratio: metronidazole 40g, clotrimazole 32g, chlorhexidine acetate 1.6g, carbomer 934 10g , glycerin 120g, triethanolamine 4g, ethylparaben 1g, and the rest is purified water.
[0018] The preparation method of a kind of Shuangzotai vaginal gel of the present invention is made according to the following steps:
[0019] ①Prepare 1000g of gel, take 40g of metronidazole, 32g of clotrimazole, and 1.6g of chlorhexidine acetate according to the weight ratio, mix them and pulverize them, pass through a 100-mesh sieve for later use;
[0020] ② Take 10g of Carbomer 934, 4g of triethanolamine and purified water according to the weight ratio; sprinkle Carbomer 934 evenly on the surface of purified water, let it sit for 40-48 hours to fully swell naturally, then add triethanolamine and stir evenly, and adjust the pH to 5- 6, make the matrix;
[0021] 3. Add ...
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