Metronidazole, clotrimazole and chlorhexidine acetate vagina gel and preparation method thereof

A technology of vaginal gel and bizoate, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. It can solve the problem of small mucosal contact surface, difficult eradication, burning sensation in patients, etc. problem, to achieve the effect of high cure rate, good bioadhesion, and good therapeutic effect

Active Publication Date: 2012-05-23
济南博利医药生物工程有限公司
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Problems solved by technology

These medicaments that this area uses all are to treat vaginitis, and vaginitis is divided into many kinds: trichomonas vaginitis, bacterial vaginitis, mycotic vaginitis, mixed vaginitis etc., these inflammations again with mixed vaginitis Vaginitis is the most difficult to eradicate, and the recurrence rate is extremely high. The use effect of these dosage forms shows that Shuangzotai has a poor therapeutic effect on mixed vaginitis. According to the analysis of the feedback from the use, the main reason is that effervescent tablets need to absorb water It can disintegrate, and there is a burning sensation for patients with vaginal dryness; suppositories need to be melted by body temperature, and the onset of action is sl...
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Abstract

The invention discloses a metronidazole, clotrimazole and chlorhexidine acetate vagina gel and a preparation method thereof. Every 1000g of gel comprises the following components by weight: 40g of metronidazole, 32g of clotrimazole, 1.6g of chlorhexidine acetate, 10g of Carbomer 934, 120g of glycerol, 4g of triethanolamine, 1g of ethylparaben and the balance pure water. The method comprises the following steps: (1) mixing the metronidazole, clotrimazole and chlorhexidine acetate based on respective weight, and crushing evenly and sieving for later use; (2) preparing the Carbomer 934, triethanolamine and pure water into a matrix based on respective weight; (3) adding glycerol, ethylparaben into the crushed components in the step (1), and stirring evenly to obtain a mixture for later use; (4) adding pure water into the mixture of the step (3), mixing evenly to prepare into 1000g of gel; and (5) carrying out encapsulation on the gel obtained in the step (4) to obtain the product of the metronidazole, clotrimazole and chlorhexidine acetate vagina gel. The metronidazole, clotrimazole and chlorhexidine acetate vagina gel disclosed by the invention has excellent treating effects, and is a medicine which is convenient to use, is non-irritant, and has no foreign body sensation and good curative effect.

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  • Metronidazole, clotrimazole and chlorhexidine acetate vagina gel and preparation method thereof
  • Metronidazole, clotrimazole and chlorhexidine acetate vagina gel and preparation method thereof

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Example Embodiment

[0016] Example
[0017] The diazotide vaginal gel of the present invention is composed of the following components in weight ratio per 1000g gel: metronidazole 40g, clotrimazole 32g, chlorhexidine acetate 1.6g, and carbomer 934 10g , 120g glycerin, 4g triethanolamine, 1g ethyl paraben, and the rest is purified water.
[0018] The preparation method of diazotide vaginal gel according to the present invention is produced according to the following steps:
[0019] ①Prepare 1000g gel, take 40g metronidazole, 32g clotrimazole and 1.6g chlorhexidine acetate according to the weight ratio, mix them, pulverize, pass through a 100 mesh sieve for use;
[0020] ②Take 10g of Carbomer 934, 4g of triethanolamine and purified water according to the weight ratio; sprinkle Carbomer 934 evenly on the surface of purified water, leave it for 40-48 hours to fully swell naturally, then add triethanolamine and stir evenly, adjust PH5- 6. Make a matrix;
[0021] ③Add 120 g of glycerin and 1 g of ethyl paraben into the pulverized medicine prepared in step ① by weight ratio, stir and mix to obtain a mixture for use;
[0022] ④ Take the mixture in step ③ and gradually add it to the matrix made in step ② under agitation, add purified water and mix uniformly to make 1000g gel;
[0023] ⑤The gel obtained in step ④ is filled and packaged according to the weight required by the specifications of 5 grams each to obtain the diazotide vaginal gel product.
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Description & Claims & Application Information

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the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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