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High-purity ginkgo flavone and composition thereof

A technology of ginkgo flavonoids and high purity is applied in the field of production technology for extracting high-purity ginkgo flavonoids, which can solve the problems of losing individual characteristics of ginkgo biloba extracts, and achieve the effects of stable and controllable product quality, simple preparation process and low cost.

Inactive Publication Date: 2011-06-01
TIANJIN TAIYANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CN200810068890 mentions a method for extracting high-purity ginkgo flavonoid aglycone. This patent adopts hydrochloric acid hydrolysis and other multi-step reactions to prepare high-purity ginkgo flavonoid aglycone, but the obtained product has lost the individual characteristics of ginkgo extract

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The extraction of Ginkgo biloba: get 400g Ginkgo biloba, add the ethanol aqueous solution (2000ml) that is 5 times of ginkgo leaf quality 20% for the first time, 70 ℃ of reflux extractions 3 hours, add 4 times of 20% ethanol aqueous solution for the second time ( 1600ml), reflux extraction at 70°C for 2 hours. The two extracts were combined, ethanol was recovered, diluted with water, allowed to stand for 4 hours, and filtered to obtain a clarified extract.

[0018] Separation and purification: the extract obtained in the previous step was passed into an adsorption resin column FL-2 (400 g) (Tianjin Orui Biotechnology Co., Ltd., publicly available), the diameter ratio of the resin column was 10:1, and the adsorption flow rate was 1 BV / H. After the adsorption is completed, use 4BV of 70% ethanol aqueous solution (2400ml) for desorption, and the flow rate is 1BV / H. Ethanol is recovered from the desorption solution to obtain a paste-like GBE product.

[0019] Preparation ...

Embodiment 2

[0021] The extraction of Ginkgo biloba: get 400kg Ginkgo biloba, add 5 times of 80% ethanol aqueous solution (2000L) for the first time, reflux extraction at 70°C for 3 hours, add 4 times of 80% ethanol aqueous solution (1600L) for the second time, 70 °C for 2 hours under reflux. The two extracts were combined, ethanol was recovered, diluted with water, allowed to stand for 4 hours, and filtered to obtain a clarified extract.

[0022] Separation and purification: Pass the extract obtained in the previous step into the adsorption resin column FL-2 (600kg) (Tianjin Orui Biotechnology Co., Ltd.), the resin column diameter ratio is 7:1, and the adsorption flow rate is 1BV / H. After the adsorption is complete, use 4BV of 70% ethanol aqueous solution (2400L) for desorption with a flow rate of 1BV / H. Ethanol is recovered from the desorption solution to obtain a paste-like GBE product

[0023] Preparation of high-purity ginkgo flavonoids: Dilute the above-mentioned pasty GBE with wat...

Embodiment 3

[0025] The extraction of Ginkgo biloba: get 400kg Ginkgo biloba, add 5 times of 50% ethanol aqueous solution (2000L) for the first time, reflux extraction at 70°C for 3 hours, add 4 times of 50% ethanol aqueous solution (1600L) for the second time, 70 °C for 2 hours under reflux. The two extracts were combined, ethanol was recovered, diluted with water, allowed to stand for 4 hours, and filtered to obtain a clarified extract.

[0026] Separation and purification: Pass the extract obtained in the previous step into an adsorption resin column FL-2 (600kg) (Tianjin Orui Biotechnology Co., Ltd.), the diameter ratio of the resin column is 8:1, and the adsorption flow rate is 1BV / H. After the adsorption is completed, use 4BV of 50% ethanol aqueous solution (2400L) for desorption with a flow rate of 1BV / H. Ethanol is recovered from the stripping solution, and standard GBE powder is obtained after vacuum or spray drying.

[0027] Preparation of high-purity ginkgo flavonoids: Dilute ...

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Abstract

The invention relates to a high-purity ginkgo flavone and a composition thereof. The high-purity ginkgo flavone is light brownish yellow, and tastes slightly bitter; the content of ginkgo flavone is greater than or equal to 50%, the peak ratio of quercetin to kaempferol is 0.8-1.2, the peak ratio of isorhamnetin to quercetin is greater than or equal to 0.15, the concentration of ginkgoic acid is smaller than 5ppm, and the content of residue on ignition is smaller than 0.8%. The water content is smaller than 5.0%. The method for preparing the high-purity ginkgo flavone comprises the following steps: extracting by heating ginkgo leaves, which are used as the raw material, under reflux with a 20-80 wt% ethanol solution; concentrating the extracting solution to recover ethanol; separating by passing through macroporous resin columns; carrying out ethanol desorption; diluting the product by adding water; adsorbing by passing the product through a gel-type hydrogen bond adsorption resin which is mainly based on hydrogen bond adsorption, and desorbing; and collecting the effluent liquid and the desorption liquid, concentrating and drying. The preparation technique is simple and reliable, has the advantage of low cost, and does not use toxic organic solvents in the process, thereby being environment-friendly. The high-purity ginkgo flavone can be made into a composition as an effective constituent, and the composition can be used as various preparations (capsules, tablets, oral liquids, granules, powder, injections and the like) of ginkgo flavone medicines or health products.

Description

technical field [0001] The invention relates to a high-purity ginkgo flavone and its composition, in particular to a production process for extracting high-purity ginkgo flavonoids from ginkgo leaves. Background technique [0002] Ginkgo biloba (Ginkgo biloba L.) is an important medicinal plant. Ginkgo biloba is the leaf of Ginkgo biloba. . In the 1970s, Germany took the lead in formulating quality standards for ginkgo extract (abbreviated as GBE), that is, standard ginkgo extract (ginkgo total flavonoids ≥ 24%, terpene lactones ≥ 6%, ginkgolic acid ≤ 10ppm), and this standard then also It has become the international international standard for ginkgo extract. Further studies have shown that high-purity ginkgo flavonoids have better efficacy in treating cardiovascular and cerebrovascular diseases than ordinary standard ginkgo extracts. Therefore, the production method of high-purity ginkgo flavonoids has also become a research hotspot in the industry in recent years. At p...

Claims

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Application Information

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IPC IPC(8): A61K36/16A61K127/00
Inventor 王为超欧来良李红艳
Owner TIANJIN TAIYANG PHARMA
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