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Medical gargle product for Xerostomia and preparation method thereof

A technology for dry mouth and medical supplies, applied in the field of medicine, can solve the problems of no medical effect, expensive side effects of medicines, and impossibility of long-term use of medicines, etc., to assist natural healing mechanism, good broad-spectrum antiviral activity, and promote wound healing healing effect

Active Publication Date: 2011-06-08
武汉耦合医学科技有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, medicines are expensive and have great side effects, and for patients with chronic diseases (such as diabetes) with dry mouth, medicines cannot be taken for a long time
At the same time, although there are a variety of saliva substitutes on the market to relieve oral symptoms, artificial saliva, oral moisturizers and lubricants only have moisturizing functions and have no other medical effects; while the imported Bioxtra series products only have imported cosmetics certificates. Cosmetics belonging to the brand of makeup do not have medical effects; doctors are unwilling to recommend them to patients, and if they recommend them, patients do not buy them because they are only imported cosmetics

Method used

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  • Medical gargle product for Xerostomia and preparation method thereof
  • Medical gargle product for Xerostomia and preparation method thereof
  • Medical gargle product for Xerostomia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] One. preparation total weight is the xerostomia medical supplies of 1000g containing semen solution:

[0031] a), take by weighing 1g carboxymethyl chitosan and be dissolved in 100g water for injection, obtain carboxymethyl chitosan solution;

[0032] b), weigh 1g lactoferrin, 0.1g immunoglobulin, 10g sorbitol, 1g methylparaben and 10g bovine colostrum extract respectively, dissolve them in 200g purified water, and obtain corresponding solutions after dissolving;

[0033] c), take by weighing 1g lysozyme and 0.1g lactoperoxidase respectively, be dissolved in 100g water for injection to obtain enzyme solution;

[0034] d), adding the remaining 575.8 g of water for injection into the solution prepared in steps a), b) and c) and stirring evenly, subpackaging and sterilizing at 85° C. for 15 minutes to obtain a finished product.

[0035] Two. Example 1 xerostomia-containing solution finished product effect detection

[0036] 1), the specific parameters of the xerostomia-c...

Embodiment 2

[0046] One. preparation total weight is the xerostomia medical supplies of 1000g containing semen solution:

[0047] a), take by weighing 50g hydroxyethyl chitosan and dissolve in 100g water for injection to obtain hydroxyethyl chitosan solution;

[0048] b), take by weighing 10g lactoferrin, 0.5g immunoglobulin, 50g xylitol, 10g ethylparaben and 100g bovine colostrum extract respectively, dissolve in 200g purified water, obtain corresponding solution after dissolving;

[0049] c), take by weighing 5g lysozyme and 0.5g lactoperoxidase respectively, be dissolved in 100g water for injection to obtain enzyme solution;

[0050] d), adding the remaining 374 g of water for injection into the solution prepared in steps a), b) and c), and stirring evenly, subpackaged and sterilized at 85° C. for 15 minutes to obtain a finished product.

[0051] Two. Example 2 xerostomia containing liquid medical supplies effect detection

[0052]1), the specific parameters of the xerostomia containi...

Embodiment 3

[0062] One. preparation total weight is the xerostomia medical supplies of 1000g containing semen solution:

[0063] a), take by weighing 20g hydroxypropyl chitosan and be dissolved in 100g water for injection, obtain hydroxypropyl chitosan solution;

[0064] b), weigh 5g lactoferrin, 1g immunoglobulin, 100g maltitol, 5g propylparaben and 50g bovine colostrum extract respectively, dissolve them in 200g purified water, and obtain corresponding solutions after dissolving;

[0065] c), take by weighing 2g lysozyme and 5g lactoperoxidase respectively, be dissolved in 100g water for injection to obtain enzyme solution;

[0066] d), adding the remaining 412 g of water for injection into the solution prepared in steps a), b) and c), and stirring evenly, subpackaged and sterilized at 85° C. for 15 minutes to obtain a finished product.

[0067] Two. Example 3 xerostomia containing liquid medical supplies effect detection

[0068] 1), the specific parameters of the xerostomia containi...

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Abstract

The invention relates to a medical gargle product for xerostomia and a preparation method thereof. The gargle comprises the following components: 0.1-5% of water-soluble chitosan, 0.1-1% of lactoferrin, 0.01-0.5% of lactoperoxidase, 0.1-0.5% of lysozyme, 0.01-0.1% of immunoglobulin, 1-10% of bovine colostrum extract, 1-10% of anti-caries sweetener, 0.1-1% of preservative and the balance of water for injections. The preparation method is characterized by firstly preparing a water-soluble chitosan solution, a solution of lactoferrin, immunoglobulin, anti-caries sweetener, preservative and bovine colostrum extract and a solution of lysozyme and lactoperoxidase respectively with part of the water for injections, mixing the prepared three solutions with the rest of the water for injections, stirring uniformly, subpackaging, and then sterilizing at 85 DEG C for 15 minutes to obtain the finished product. The gargle has the effects of immediately and rapidly moistening, comforting and freshening the oral cavity and the functions of resisting bacteria and viruses, preventing dental plaque, reducing gum inflammation and blooding and oral ulcer, promoting the healing of wounds in the oral cavity and preventing oral candidiasis. The gargle has the advantages of simple and convenient large-scale production process and no environmental pollution in the production process.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a medical product containing liquid for xerostomia and a preparation method thereof. The medical product is non-irritating to the oral cavity, has good stability, good taste and instant and rapid treatment of dry mouth disease effect. Background technique [0002] Xerostomia is the main complaint of dry mouth, a symptom of subjective feeling, and objective dry mouth (negative balance of saliva caused by decreased secretion or increased consumption of saliva in the oral cavity due to various reasons) stimulation reaches a certain threshold As for the subjective feeling caused, the threshold of this feeling has great individual differences, so the subjective feeling of dry mouth (xerostomia) is not always accompanied by objective dry mouth. With the improvement of people's quality of life and the enhancement of self-care awareness, more and more patients seek medical ...

Claims

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Application Information

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IPC IPC(8): A61K39/395A61K9/08A61P1/02A61P31/02A61P31/12A61P31/10A61K31/722A61K38/40A61K38/44A61K38/47A61K35/20
Inventor 官培龙黄利苹谭伟
Owner 武汉耦合医学科技有限责任公司
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