Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Medicament sustained-release coating

A drug and sustained-release technology, applied in the field of medical materials, can solve the problems of short time, inability to achieve therapeutic effect, and limited amount of drug applied, to promote healing, improve the control of drug release rate and direction, and inhibit smooth muscle. value-added effect

Inactive Publication Date: 2011-06-15
TIANJIN TIANXIANG GLASSWARE
View PDF0 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, it has been proposed to prevent restenosis by coating drugs that prevent the proliferation of smooth muscle cells on coronary stents. Due to the single type of drugs coated on the surface of the stent, its effects are limited; and the amount of drugs coated is also very high. Limited, so that the time for the drug to act on the tube wall is relatively short, so the desired therapeutic effect cannot be achieved

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0033] The preparation method of the compound mushroom functional drink comprises the following steps:

[0034] (1) adding one or more umami flavor agents composed of sodium glutamate, sodium succinate or sodium 5'-inosinate in proportion to the compound mushroom concentrate to become the main ingredient of the compound mushroom functional drink;

[0035] (2) Adding one or more salts composed of sodium chloride, sodium citrate or other salts in the compound mushroom concentrated liquid according to the proportion, to become the main ingredient of the compound mushroom functional drink;

[0036] (3) Add or not add flavoring agents such as ethyl maltol to the compound mushroom concentrate to become the main ingredient of the compound mushroom functional drink;

[0037] (4) Add one or more of sucrose or fructose or fructose syrup or maltose syrup to the main ingredient of the compound mushroom functional drink according to the ratio;

[0038] (5) Adding or not adding sweeteners ...

Embodiment

[0043] (Take 1000kg finished product as an example).

[0044] The components and weight of this compound mushroom functional drink are as follows:

[0045] Compound Mushroom Concentrate 300kg

[0046] Sugar 80kg

[0047] Sour agent 0.4kg

[0048] Salt 0.6kg

[0049] Flavor agent 0.24kg

[0050] Flavor enhancer 0.1kg

[0051] Treated water 680kg

[0052] The above-mentioned compound mushroom concentrate is made by scientifically extracting and concentrating tea tree mushroom as the main raw material together with Hericium erinaceus, Ganoderma lucidum, Shiji mushroom and other edible fungi.

[0053] The above-mentioned sugar material is composed of one or more of sucrose or fructose or fructose syrup or glucose or maltose syrup, and the added weight is 80kg. There is no special requirement for the dosage of the above-mentioned various raw material mixtures, so this embodiment is not necessary. Give specific dosage.

[0054] The above-mentioned salts are composed of one o...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a medicament sustained-release coating. A double-medicament sustained-release coating consists of medicaments and a polymer carrier, wherein the medicaments are used for inhibiting thrombosis and hyperblastosis. The double-medicament sustained-release coating is characterized in that: an external medicament sustained-release coating is applied on the surface of a coronary artery stent; an internal medicament sustained-release coating is placed in a micropore storage groove of the coronary artery stent; the external medicament sustained-release coating is applied on the surface of the coronary artery stent by an ultrasonic atomizing spraying process; the polymer carrier is polylactic acid-glycolic acid (PLGA); and the weight ratio of the polymer carrier to the medicaments is 3:1-10:1. The double-medicament sustained-release coating has the advantages of: 1, guaranteeing that the medicaments can adopt different release sequences and different duration time according to different pathogenesis; 2, maintaining stable blood medicament effective concentration so as to inhibit restenosis of blood vessels and thrombosis; 3, inhibiting proliferation of smooth muscles, reducing thrombosis, promoting healing and improving endothelial function; and 4, greatly improving control of medicament release rate and directivity.

Description

technical field [0001] The invention relates to a coronary stent in the field of medical materials, in particular to a drug slow-release coating. Background technique [0002] Percutaneous balloon intraluminal coronary angioplasty is a new treatment method for treating cardiovascular diseases in recent years. Coronary artery stenting is developed on this basis to treat and prevent coronary stenosis and restenosis. effective method. After the usual metal stent is implanted into the human body, the direct contact of the metal surface with the blood vessel wall and blood stimulates the human body's ability to reject foreign bodies, resulting in hyperplasia of vascular intimal tissue and smooth muscle cells, resulting in restenosis. In recent years, it has been proposed to prevent restenosis by coating drugs that prevent the proliferation of smooth muscle cells on coronary stents. Due to the single type of drugs coated on the surface of the stent, their effects are limited; and...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/08A61L31/16
Inventor 苏万海
Owner TIANJIN TIANXIANG GLASSWARE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com