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Eye drops containing vitamin E derivatives and preparation method thereof

A technology of derivatives and eye drops, which is applied in the field of eye drops containing vitamin E derivatives and its preparation, can solve the problems of low local concentration, failure to achieve therapeutic effect, low bioavailability, etc., to increase the action time, Unique Antioxidant Effect

Active Publication Date: 2012-05-30
广州智园生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This type of eye drops is often quickly drained on the eye surface, and is blocked by the tear film, cornea, and conjunctival epithelial barrier at the same time, resulting in short drug absorption time, low local concentration, low bioavailability, and short duration of effect. The therapeutic effect of

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Weigh 0.01 g of polyethylene glycol 1000 vitamin E succinate and dissolve it in 50 ml of 90℃ water for injection, and cool to room temperature for later use; weigh 0.1 g of sodium hyaluronate and dissolve in 100 ml of 80℃ water for injection, and cool to room temperature for later use ; Weigh 0.1 g of phosphoric acid-phosphate buffer reagent and 5.8 g of sodium chloride and dissolve them in 700ml of water for injection, add cooled polyethylene glycol 1000 vitamin E succinate solution and sodium hyaluronate solution, add water for injection The volume is adjusted to 1000ml, the pH is adjusted to 6.5-7.4, and the eye drops of the present invention are obtained by autoclaving.

Embodiment 2

[0027] Weigh 0.1g polyethylene glycol 1000 vitamin E succinate and dissolve it in 50ml 80℃ water for injection, and cool to room temperature for later use; weigh 0.2g sodium hyaluronate and dissolve it in 100ml 80℃ water for injection, and cool to room temperature for later use ; Weigh 5 grams of phosphoric acid-phosphate buffer reagent and 6.5 grams of potassium chloride and dissolve them in 700ml of water for injection, add cooled polyethylene glycol 1000 vitamin E succinate solution and sodium hyaluronate solution, and add water for injection The volume is adjusted to 1000ml, the pH is adjusted to 6.5-7.4, and the eye drops of the present invention are obtained by autoclaving.

Embodiment 3

[0029] Weigh 0.2 g of polyethylene glycol 1000 vitamin E succinate and dissolve it in 100 ml of 85°C water for injection, and cool to room temperature for later use; weigh 0.5 g of hydroxypropyl methylcellulose and dissolve in 100 ml of 4°C water for injection; 6 grams of phosphoric acid-phosphate buffering reagent and 5.8 grams of sodium chloride are dissolved in 700ml of water for injection, and the cooled polyethylene glycol 1000 vitamin E succinate solution and hydroxypropyl methylcellulose solution are added to the water for injection. The volume is 1000ml, the pH is adjusted to 6.5-7.4, and the 0.2μm filter membrane is filtered and sterilized to obtain the eye drops of the invention.

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PUM

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Abstract

The invention discloses eye drops containing vitamin E derivatives and a preparation method thereof. The eye drops comprise main components of water soluble vitamin E derivatives, a thickening agent, a pH regulator, an isotonic agent and water for injection. The eye drops are mainly used for treating dry eye syndrome, and active pharmacological components can be added according to the need and are used for adjuvant treatment of cataract, retinopathy, macular degeneration, keratitis, conjunctivitis and other various ocular diseases. The eye drops have good effects of moisturizing and lubricating, have antioxidation function, can inhibit lipid peroxide reactions in eyes, have effects of expanding peripheral blood vessels, improving blood circulation, protecting, and accelerating injuries toheal, and have good curative effects on various ocular diseases.

Description

Technical field [0001] The invention belongs to the field of medicine technology. It relates to an eye drop and a preparation method thereof, in particular to an eye drop containing a vitamin E derivative and a preparation method thereof. The eye drops of the present invention are mainly used to treat dry eye, and can also assist in the treatment of cataracts, retinopathy, macular degeneration, keratitis, conjunctivitis and other ophthalmic diseases. Background technique [0002] Ophthalmic diseases mainly include dry eye, cataract, glaucoma, infectious inflammation of the eye, macular degeneration, retinopathy and other diseases. Among them, dry eye refers to a type of disease that causes the instability of the tear film and damage to the ocular surface due to the abnormality of the quality or quantity of the tear fluid, or the abnormality of the kinetics of the tear fluid, which causes eye discomfort and other symptoms. Environmental pollution, wearing contact lenses, unsanit...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/355A61K45/06A61P9/10A61P27/02A61P27/12
Inventor 魏坤凌友张婕
Owner 广州智园生物科技有限公司
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