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Qingpeng gel for relieving pain and subdhing swelling and preparation method thereof

A technology of gel and gel matrix, which is applied in the direction of non-central analgesics, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve the problem of unstable sources of raw materials and excipients, which affect the efficacy of products And promotion, can not fully guarantee the curative effect and other issues, to achieve the effect of reducing drug dosage, improving bioavailability, and fast transdermal absorption

Active Publication Date: 2011-06-22
TIBET QIZHENG TIBETAN MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] According to the records of "Four Medical Codes" and "Jingzhu Materia Medica", combined with long-term practical experience, Tibetan folk doctors use Oxytropis falciparum, sub-rhubarb, iron bar hammer, myrobalan, myrobalan, emblica, benzoin, and gluten The Tibetan medicine Qingpeng ointment produced from rattan and musk is trusted by the majority of patients for its remarkable therapeutic effect. However, the traditional preparation process of Tibetan medicine Qingpeng ointment is to mix all the original medicinal materials with fine powder to make ointment. The process is complicated. The batch production cycle is long and the production process is unstable; the sources of raw materials and excipients are unstable, which is not conducive to industrial production; some drugs have poor penetration ability and low bioavailability, so the curative effect cannot be fully guaranteed, and the curative effect of the drug is not suitable; in addition, the product is not suitable for storage and carrying. Inconvenient; Due to various reasons, it greatly affects the efficacy and promotion of the product
[0007] At present, there are no literatures and reports about the preparation of the gel by modifying the dosage form based on the prescription of the traditional Tibetan medicine Qingpeng ointment

Method used

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  • Qingpeng gel for relieving pain and subdhing swelling and preparation method thereof
  • Qingpeng gel for relieving pain and subdhing swelling and preparation method thereof
  • Qingpeng gel for relieving pain and subdhing swelling and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0104] The preparation method of Qingpeng gel of the present invention comprises a kind of in A and B method:

[0105] A method:

[0106] ① Remove impurities, wash, dry, and pulverize Oxytropis, subrhubarb, iron bar hammer, myrobalan, myrobalan, emblica, benzoin, and vine respectively into a powder with a particle size of 0.1-150 μm;

[0107] ② Grind musk into fine powder;

[0108] ③ Add distilled water to the gel skeleton material, soak overnight to make it fully swell, add pH regulator, stabilizer, skin penetration accelerator, humectant, surfactant and bacteriostat, stir evenly, and make a gel matrix;

[0109] ④ After mixing the medicated powder obtained in the above step ①, the musk fine powder obtained in step ② and the gel matrix obtained in step ③, add an appropriate amount of water, stir evenly, let stand, and pack to obtain the gel agent of the present invention;

[0110] Method B:

[0111] ① Remove impurities, purify and mix Oxytropis, Subrhubarb, Tiebhammer, Myro...

experiment example 1

[0224] Experimental Example 1: Screening Experiment of Gel Excipients of the Present Invention

[0225] 1. Optimal test for gel matrix

[0226] ① Selection of gel matrix

[0227] Weigh 100g of thorn bean, 50g of sub-rhubarb, 75g of iron club hammer, 100g of myrobalan, 100g of myrobalan, 100g of amla japonica, 35g of benzoin, 150g of vines, and 25g of musk; grind musk into fine powder; the rest of the medicinal materials are used as medicinal materials 10 times the total weight of water, decocted 3 times for 2 hours each time, collected and combined the extract and volatile oil, filtered and concentrated the extract into a concentrated solution with a relative density of 1.05-1.15, and added the volatile oil to the concentrated solution Concentrated solution a was obtained in the middle; 500 g of gel matrix were weighed respectively, and an appropriate amount of distilled water was added, soaked overnight to make it fully swollen, and 45 g of Azone, 72 g of glycerol, and 2.5 g...

experiment example 2

[0276] Experimental example 2: Qingpeng gel of the present invention and Qingpeng ointment transdermal absorption test comparison

[0277] 1. Test sample:

[0278] Traditional Qingpeng ointment: provided by Tibet Qizheng Tibetan Medicine Co., Ltd.;

[0279] Qingpeng ointment 1: Preparation method: ①Pure Oxytropis 100g, subrhubarb 50g, iron rod hammer 75g, chebula 100g, chebula 100g, emblica 100g, benzoin 35g, and vine vine 150g, crush and mix Uniform and ready for use; ②Weigh 50% of the total weight of the above-mentioned mixed raw materials, use 2.13kg of water, decoct 3 times at 85°C, decoct for 2 hours each time, collect the extract and volatile oil respectively; filter, concentrate and extract Add the volatile oil to the concentrated solution; ③ Grind the above-mentioned remaining mixed raw material medicine into a 100 μm powder, and mix it with the above-mentioned concentrated solution containing volatile oil to obtain a mixed solution a; Add liquid a to 50 times the we...

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Abstract

The invention provides gel for subdhing swelling and relieving pain, which comprises an active ingredient and a gel substrate, wherein the active ingredient is prepared from the following raw material medicaments in part by weight: 80 to 120 parts of oxytropis, 30 to 70 parts of sub-rhubarb, 50 to 100 parts of tiebangchui aconite tuber, 80 to 120 parts of core removal medicine terminalia fruit, 80 to 120 parts of terminalia bellerica, 80 to 120 parts of emblic leafflower fruit, 20 to 50 parts of benzoin, 130 to 170 parts of Chinese tinospora stem and 10 to 40 parts of musk; and the substrate comprises the following auxiliary materials in part by weight: 40 to 1,600 parts of gel framework material. The gel has the advantages of no foreign body sensation, high adhesiveness at positions of pathological changes, no irritation to skin mucous membranes, no pollution of clothes and the like.

Description

technical field [0001] The present invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a gel preparation and a preparation method thereof. Background technique [0002] Qingpeng ointment is a classic Tibetan medicine prescription composed by Tibetan folk doctors according to the records of "Tibetan Medicine and Medical Supplements and Interpretation Difficulties" and "Four Medical Classics" and combined with practical experience. The first volume of medicine, 322 pages. Qingpeng ointment is prescribed as: [0003] 100g sickle thorn bean, 50g rhubarb, 75g iron club hammer, 100g myrobalan, 100g myrobalan, 100g amla japonica, 35g benzoin, 150g wide tendon vine, 25g musk. [0004] Preparation method: The above nine flavors are ground into fine powder except musk, which is separately ground into fine powder, sieved, added musk fine powder, mixed well, and mixed with 8-year-old child urine, lard or aged ghee to make an ointment, t...

Claims

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Application Information

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IPC IPC(8): A61K36/714A61K9/00A61K47/32A61K47/34A61K47/36A61K47/38A61K47/42A61K47/44A61P29/00A61K35/55A61K47/10
Inventor 刘海龙张国霞陈丽娟张樱山卢伍党
Owner TIBET QIZHENG TIBETAN MEDICINE
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