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Porous hydroxy calcium phosphate nanometer particle-modified titanium-based titanate nanowire biologic support material and preparation method thereof

A technology of calcium hydroxyphosphate and titanium-based titanate, which is applied in metal material coating process, superimposed layer plating, coating and other directions, can solve the problems of incomplete surface pores, low mechanical properties, difficult forming and processing, etc. The effect of easy operation, low equipment investment and low production cost

Active Publication Date: 2011-06-22
万家润(常州)环保新材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the mechanical properties of this type of material are low, the surface pores are incomplete, the forming process is difficult, and the price is high, which limits its further application.

Method used

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  • Porous hydroxy calcium phosphate nanometer particle-modified titanium-based titanate nanowire biologic support material and preparation method thereof
  • Porous hydroxy calcium phosphate nanometer particle-modified titanium-based titanate nanowire biologic support material and preparation method thereof
  • Porous hydroxy calcium phosphate nanometer particle-modified titanium-based titanate nanowire biologic support material and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0033] Embodiment 1: The present embodiment carries out according to the following steps:

[0034] (1) Preparation of titanium-based titanate nanowires with grid-like microporous structure by dissolved salt method. The specific preparation method is as follows: the titanium metal substrate is ultrasonically cleaned in acetone and absolute ethanol solutions at room temperature for 20 minutes, and then rinsed with distilled water for 4 times. Ba(OH) 2 ﹒ 8H 2 The mixed solution of O was sealed in a polytetrafluoroethylene reactor, and after reacting at 280 °C for 16 h, a titanium-based titanate nanowire with a grid-like microporous structure was obtained, and the titanium-based titanate nanowire was used Rinse with deionized water until neutral, and air dry.

[0035] (2) Porous calcium hydroxyphosphate nanoparticles modified titanium-based titanate nanowire bioscaffolds were prepared by electrochemical deposition. The specific preparation process is as follows: In the three-...

Embodiment 2

[0051] Embodiment 2: The present embodiment carries out according to the following steps:

[0052] (1) Titanium-based titanate nanowires with grid-like microporous structure prepared by dissolved salt method. The specific preparation method is as follows: the titanium metal substrate is ultrasonically cleaned in acetone and absolute ethanol solutions at room temperature for 20 min, and then rinsed with distilled water for 4 times. Ba(OH) 2 ﹒ 8H 2 The mixed solution of O was sealed in a polytetrafluoroethylene reactor, and after reacting at 200 °C for 8 h, a titanium-based titanate nanowire with a grid-like microporous structure was obtained, and the titanium-based titanate nanowire was used Rinse with deionized water until neutral, and air dry.

[0053] (2) Porous calcium hydroxyphosphate nanoparticles modified titanium-based titanate nanowire bioscaffolds were prepared by electrochemical deposition. The preparation process is as follows: in the three-electrode reaction c...

Embodiment 3

[0057] Embodiment 3: the present embodiment carries out according to the following steps:

[0058] (1) Titanium-based titanate nanowires with grid-like microporous structure prepared by dissolved salt method. The specific preparation method is as follows: the titanium metal substrate is ultrasonically cleaned in acetone and absolute ethanol solutions at room temperature for 20 min, and then rinsed with distilled water for 4 times. Ba(OH) 2 ﹒ 8H 2 The mixed solution of O was sealed in a polytetrafluoroethylene reactor, and after reacting at 100 °C for 1 h, a titanium-based titanate nanowire with a grid-like microporous structure was obtained, and the titanium-based titanate nanowire was used Rinse with deionized water until neutral, and air dry.

[0059] (2) Porous calcium hydroxyphosphate nanoparticles modified titanium-based titanate nanowire bioscaffolds were prepared by electrochemical deposition. The preparation process is as follows: in the three-electrode reaction c...

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Abstract

The invention discloses a porous hydroxy calcium phosphate nanometer particle-modified titanium-based titanate nanowire biologic support material and a preparation method thereof, and belongs to the field of nanometer biologic materials. In the biologic support material, a titanium-based titanate nanowire with a grid micropore structure is formed by growing a titanate nanowire on a titanium metal substrate; and a porous hydroxy calcium phosphate nanometer particle coating is grown on the surface of the titanium-based titanate nanowire. In the biologic support material, porous hydroxy calcium phosphate nanometer particles are modified on the titanium-based titanate nanowire, so that the biocompatibility and biologic inductivity of the titanium-based titanate nanowire can be improved effectively. Simultaneously, a large quantity of gaps are reserved on the surface and inner part of porous hydroxy calcium phosphate, so the porous hydroxy calcium phosphate is favorable for the loading and control release of medicaments or cell growth factors and can promote newborn bones to grow further to realize double effects of medicinal treatment and bone transplantation or damage repair.

Description

technical field [0001] The invention belongs to the field of nano biological materials. In particular, it relates to a novel titanium-based titanate nanowire bio-scaffold material modified by porous calcium hydroxyphosphate nanoparticles and a preparation method thereof, which can be used for bone transplantation or damage repair. Background technique [0002] Due to the increasingly prominent problems of traffic accidents, sports trauma, social aging and the pursuit of a high-level quality of life, people's demand for medical devices and biomedical materials is increasing day by day. At present, stainless steel is widely used in clinical bone grafting or damaged repair materials. , titanium or titanium and its alloy surface coating materials, but its stress shielding effect, harmful ion dissolution phenomenon, osteoinductive properties and poor corrosion resistance often lead to implant failure. In particular, the surface of the implanted material cannot provide a good gro...

Claims

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Application Information

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IPC IPC(8): A61L27/32A61L27/06A61L27/54A61L27/56C23C28/04
Inventor 董文钧赵海新
Owner 万家润(常州)环保新材料有限公司
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