Preparation method and application of protein drug for collagen targeted therapy of hyperplastic scar

A targeted technology for hypertrophic scars, applied in drug combinations, peptide/protein components, medical preparations containing active ingredients, etc., can solve problems such as no effective solutions, reduce treatment costs, reduce drug dosage, The effect of reducing toxic side effects
CN102115495AInactive Publication Date: 2011-07-06FOURTH MILITARY MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
FOURTH MILITARY MEDICAL UNIVERSITY
Publication Date
2011-07-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the field of gene engineering and relates to a targeted hIL-10 recombinant protein called as CBD-IL-10 for short and the application of the CBD-IL-10. The recombinant protein is a recombinant protein expressed by a CBD polypeptide combined by human interlenkin10, hIL-10 and collagen specificity after the fusion in a gene level, and a new protein is generated after recombination. The protein has the anti-virus and anti-tumor activities as well as the immune function same as the hIL-10; and more importantly, the CBD-IL-10 can be combined with the collagen specificity in a targeted way during the wound healing process and can prevent and inhibit the formation of scars in the application of the drug for treating the hyperplastic scar and keloid.
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Description

technical field

[0001] The invention belongs to the technical field of genetic engineering, and in particular relates to the technical field of immune function regulation and gene recombinant expression in the field of immunology. The CBD polypeptide specifically combined with human interleukin 10 (hIL-10) and collagen at the gene level The recombinant protein expressed after fusion and the application of the recombinant protein. Background technique

[0002] After the skin injury has healed, the scar continues to proliferate and develop into a hypertrophic scar. Hypertrophic scars protrude from the skin, irregular in shape, uneven, flushed and congested, and firm in texture. There is burning pain and itching, and the symptoms are aggravated when the ambient temperature increases, emotional, or eating spicy and irritating food. Hyperplasia often lasts for several months or years before gradually degenerating, manifested as a reduction in the height of the protrusions, dark...

Claims

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