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Application of para-thymol, salts ramification thereof or esters ramification thereof in animal feed additive

一种百里香酚、动物饲料的技术，应用在动物饲料、动物饲料、应用等方向，能够解决易挥发损失、毒性强、挥发性强等问题，达到促进动物生长、抗菌活性强、挥发性低的效果

Active Publication Date: 2011-07-27
NANXIONG YINGSAITE FINE CHEM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although the oregano oil with thymol and carvacrol as the main components can partially improve the production performance of animals when used as a feed additive, it has three defects that limit its application in the feed industry: 1. Strong irritation Odor not only affects feed processing but also reduces animal feed intake; ②It is highly volatile, so that it must be used in larger doses during the volatile loss during feed storage; ③Thymol and carvacrol are relatively toxic to animals (to large The oral median lethal doses for rats are 980mg / kg and 810mg / kg body weight respectively), with a narrow safety range and weak mutagenicity

Method used

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  • Application of para-thymol, salts ramification thereof or esters ramification thereof in animal feed additive
  • Application of para-thymol, salts ramification thereof or esters ramification thereof in animal feed additive
  • Application of para-thymol, salts ramification thereof or esters ramification thereof in animal feed additive

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1 to the synthesis of thymol salt derivatives or ester derivatives

[0021] (1) Synthesis of p-thymol sodium: get 75.1 grams of p-thymol and be dissolved in 500ml tetrahydrofuran solution, add 20 grams of sodium hydride (60%wt) while stirring under ice-bath conditions, after reacting for 2 hours, the reactant is vacuum The solvent was distilled off under reduced pressure to obtain sodium p-thymol.

[0022] (2) Synthesis of ammonium p-thymol: get 75.1 grams of p-thymol and be dissolved in 500ml tetrahydrofuran solution, feed ammonia continuously under the condition of continuous stirring (200rpm), stop the reaction after 6h, reactant vacuum vacuum distillation is removed The solvent is p-thymol ammonium.

[0023] (3) Synthesis of p-thymol resin salt: get 50 grams of p-thymol sodium and be dissolved in 1000ml water, add 200 grams of pretreated strong basic polystyrene anion resin, after continuous stirring reaction at room temperature for 6 hours, filter , wa...

Embodiment 2

[0025] Embodiment 2 Thymol and thymol and carvacrol volatility comparative test

[0026] (1) Test material

[0027] P-thymol, thymol and carvacrol: purchased from SIGMA company;

[0028] Vacuum drying oven and circulating water pump: Shanghai Yiheng Test Equipment Factory.

[0029] (2) Test method

[0030] ①Comparison of volatility among thymol, thymol and carvacrol

[0031] 10.0 g of p-thymol, thymol and carvacrol were accurately weighed and placed in a vacuum drying oven, and dried under reduced pressure at 50° C., 70° C. and 90° C. for 1 hour, respectively. The remaining weight is then weighed to compare the volatility of the different compounds.

[0032] ②Changes of p-thymol, thymol and carvacrol during storage in feed

[0033] Chicken full price compound feeds containing 100ppm (mass) p-thymol, thymol or carvacrol respectively were prepared and stored at room temperature (25-30° C.) for a long time. After storage for different times (1, 15, 30, 45, 60 days), samples...

experiment example 3

[0043] Experimental example 3 is measured to the safety of thymol etc. (rat LD 50 Determination, improved Cole's method)

[0044] ① Test material

[0045] Wistar rats were purchased from the Experimental Animal Center of Southern Medical University, with a body weight of 120-150 grams, half male and half male.

[0046] Samples for testing: p-thymol, thymol and carvacrol.

[0047] Equipment: syringes, gavage needles, rat cages

[0048] ②Test method

[0049] A. The doses causing 0% (Dn) and 100% (Dm) death of animals were obtained through preliminary experiments, wherein the Dn and Dm of thymol, thymol and carvacrol are shown in Table 3.

[0050] Table 3 Thymol, thymol and carvacrol etc. to rat LD50 preliminary test result (Dn and Dm)

[0051] compound

Dn (mg / kg body weight)

Dm (mg / kg body weight)

p-thymol

4000

8000

Thymol

400

1800

Carvacrol

400

1800

[0052] B, this experiment requires that the max...

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Abstract

The invention discloses an application of para-thymol, salts ramification thereof or esters ramification thereof in an animal feed additive. The para-thymol is isomeride of thymol and has the chemical name of 3-methyl-4-isopropyl phenol. The salts ramification of the para-thymol comprises salts formed by para-thymol and metal ions, para-thymol ammonium formed by para-thymol and ammonium, resin salt formed by para-thymol and negative ion resins and the like; and the esters ramification of the para-thymol comprises esters formed by para-thymol and different carboxylic acids. The application firstly discovers that the para-thymol, the salts ramification or the esters ramification is higher in antibacterial activity, lower in volatility, higher in safety and lower in thrill compared with the thymol and the carvacrol. When being taken as the additive of the animal growth promoting feed, the para-thymol, the salts ramification thereof or the esters ramification thereof is better in palatability and growth promoting effect compared with the thymol or the carvacrol.

Description

technical field [0001] The invention particularly relates to the application of p-thymol and its salt or ester derivatives as animal feed additives, and belongs to the field of feed. Background technique [0002] The use of feed antibiotics (AGPs) was considered to be the greatest biotechnology in animal husbandry production in the 20th century. It was first reported in 1946 that streptomycin could stimulate the growth of chicks, and it was first approved by the US Food and Drug Administration (FDA) in 1950. Antibiotics are used as feed additives. Since then, while antibiotics have been widely used to treat and prevent bacterial diseases, they have also been widely promoted and applied as feed additives, playing an extremely important role in controlling infectious diseases in livestock and poultry and promoting the healthy development of modern aquaculture. . However, as antibiotics are used more and more, their various disadvantages are gradually being recognized by peop...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K1/16
CPCA23K1/184A23K1/1646A23K1/1826A23K1/1609A23K1/1893A23K1/1631A23K1/1612A23K1/1813A23K1/16A23K20/10A23K20/105A23K20/111A23K20/147A23K50/10A23K50/30A23K50/60A23K50/75
Inventor 彭险峰覃宗华
Owner NANXIONG YINGSAITE FINE CHEM TECH CO LTD
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