Cefcapene pivoxil hydrochloride composition and preparation method thereof

A technology of cefcapine hydrochloride and a composition, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, sugar-coated pills, etc., can solve the problems of difficult disintegration of cefcapine hydrochloride tablets, unqualified dissolution rate, etc.
CN102138924BActive Publication Date: 2013-01-09CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD
Publication Date
2013-01-09

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Abstract

The invention relates to a cefcapene pivoxil hydrochloride composition and a preparation method thereof. The composition consists of a tablet core and a coating layer, wherein the tablet core contains cefcapene pivoxil hydrochloride, a filler, a disintegrating agent, an antisticking agent and a lubricating agent; the grain diameter of the cefcapene pivoxil hydrochloride serving as a raw material is less than 100 micrometers; and the antisticking agent is in an amount which is 3 to 15 percent of the weight of the tablet core. The prepared cefcapene pivoxil hydrochloride tablets have excellent disintegrative property and dissolution of over 75 percent.
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Description

technical field

[0001] The invention relates to the field of pharmaceutical preparations, in particular to a cefcapene hydrochloride composition and a preparation method thereof. Background technique

[0002] Cefcapene pivoxil hydrochloride (cefcapene pivoxil hydrochloride), its chemical name is (6R, 7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-pentenylamino]-3 -[(aminocarbonyl)oxy]methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (2,2-dimethyl Oxypropoxymethyl) ester hydrochloride monohydrate is an oral broad-spectrum antibiotic with valproyloxymethyl and stable to β-lactamase developed by Shionogi, Japan, in July 1997 It is listed in Japan under the trade name Flomox. It exerts antibacterial effect by blocking the synthesis of bacterial cell walls. It is mainly suitable for respiratory tract infections, otitis media, sinusitis, urinary tract infections, skin and skin tissue infections, and biliary tract infections caused by sensitive bacteria. Tablets are curren...

Claims

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