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Medlar floating tablet for treating chronic gastritis and preparation method thereof

The invention relates to a gastric floating tablet and a technology for chronic gastritis, which is applied to the medlar floating tablet for treating chronic gastritis and the field of preparation thereof, and can solve the problems of low bioavailability of capsules, short duration of lesions, and many times of taking medicine, and achieve enhanced gastric mucosal protection, Significant medicinal effect and immune-boosting effect

Inactive Publication Date: 2011-08-03
刘宝虎 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are a lot of Chinese patent medicines that have been marketed in my country for the treatment of chronic gastritis, but the general dosage forms are aging, and the traditional decoctions, granules, tablets, and capsules composed of traditional Chinese medicines ranging from a few to dozens of Chinese medicines have low bioavailability. It takes a short time to effectively act on the lesion, which is a waste of resources, takes more medicines, and the effect is relatively poor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Take 800g wolfberry, clean it, dry it, grind it into a coarse powder, decoct it with purified water for three times, and decoct it with 8 times the amount of purified water for 1 hour each time, let it stand, filter, combine the filtrate, concentrate, add 95% ethanol to precipitate , filtered, concentrated and made into an extract with a relative density of 1.050 to 1.200, vacuum-dried, crushed, and passed through a 80-mesh sieve; dried, crushed, and passed through a 100-mesh sieve; The powder, 310g of hydroxypropylmethylcellulose and 70g of hydroxyethylcellulose are evenly mixed, added with appropriate amount of purified water to moisten to make granules, dried, and compressed into tablets to make finished Lycium barbarum gastric floating tablets.

[0017] Quality control: According to the requirements of the Chinese Pharmacopoeia, the appearance is complete and smooth, the color is uniform, and the hardness is suitable.

[0018] Weight difference: less than ±10%.

[...

Embodiment 2

[0023] Take 600g of wolfberry, clean it, dry it, powder it into a coarse powder, decoct it with purified water three times and decoct it with 10 times the amount of purified water for 1.5 hours each time, let it stand, filter, combine the filtrate, concentrate, add ethanol to precipitate, filter 1.050 ~ 1.200 concentrated extract, vacuum-dried, crushed, and passed through a 80-mesh sieve; dried, crushed, and passed through a 100-mesh sieve; the above-mentioned wolfberry extract and 73g of sea octopus powder, and hydroxypropyl octopus 300g of methylcellulose and 100g of hydroxyethylcellulose were moistened with an appropriate amount of purified water to make granules, dried, and pressed into tablets to make finished Lycium barbarum gastric floating tablets.

[0024] Quality control: According to the requirements of the Chinese Pharmacopoeia, the appearance is complete and smooth, the color is uniform, and the hardness is suitable.

[0025] Weight difference: less than ±10%.

...

example 3

[0030] Take 1000g wolfberry, clean it, dry it, powder it into a coarse powder, decoct it with purified water three times and decoct it with 8 times the amount of purified water for 2 hours each time, let it stand, filter, combine the filtrate, concentrate, add ethanol to precipitate, filter 1.050 ~ 1.200 concentrated extract, vacuum-dried, crushed, and passed through a 80-mesh sieve; dried, crushed, and passed through a 100-mesh sieve; the above-mentioned wolfberry extract and 70g of sea octopus powder, and hydroxypropyl octopus 300g of methylcellulose and 60g of hydroxyethylcellulose were moistened with an appropriate amount of purified water to make granules, dried, and pressed into tablets to make finished Lycium barbarum gastric floating tablets.

[0031] Quality control: According to the requirements of the Chinese Pharmacopoeia, the appearance is complete and smooth, the color is uniform, and the hardness is suitable.

[0032] Weight difference: less than ±10%.

[0033]...

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Abstract

The invention relates to a medlar floating tablet for treating chronic gastritis and a preparation method thereof. The medlar floating tablet comprises medlar extractum, cuttlebone, hydroxy propyl methyl cellulose and hydroxyethyl cellulose, is developed according to screening of clinical prescriptions of modern Chinese medicine by combination with modern Chinese medical pharmacology and preparation method thereof; the medicinal values of the medlar and the cuttlebone and the foaming function of the cuttlebone are sufficiently utilized; and the hydroxy propyl methyl cellulose and the hydroxyethyl cellulose serve as hydrophilic gel skeleton materials, so that the medlar floating tablet can expand gradually in gastric juice to wrap carbon dioxide produced after the reaction of a foaming agent and the gastric juice so as to reduce the density of the tablet; and therefore the floating effect of the medlar floating tablet in the stomach is favorably achieved, the action time of the medlar and the cuttlebone in the stomach is prolonged, effective components are easy to absorb, the action is more durable, and the medical effect is more obvious. The medlar floating tablet is particularly suitable for chronic superficial gastritis and chronic atrophic gastritis; any toxic or side effect is not found; and the raw materials are wide in sources and low in cost, and are easy to obtain.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine pharmacy, in particular to a wolfberry floating tablet for treating chronic gastritis and a preparation method thereof. Background technique [0002] Chronic gastritis is a common digestive tract disease in clinical practice. The main pathological change is non-specific inflammation of the gastric mucosa. The incidence rate is high and increases with age, accounting for about 80%-90% of outpatients. The main manifestations of chronic superficial gastritis (CSG) are the most common symptoms of chronic upper abdominal burning pain, dull pain, distending pain, abdominal distension, belching, loss of appetite, acid reflux, nausea and vomiting, fatigue, constipation or diarrhea, bleeding, etc., the general course of the disease Lingering, prone to repeated attacks, deeply suffered by patients. If it is not treated in time, it will easily develop into chronic atrophic gastritis and...

Claims

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Application Information

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IPC IPC(8): A61K36/815A61K9/20A61K47/38A61P1/04A61K35/56A61K35/618
Inventor 刘宝虎江立富
Owner 刘宝虎
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