Veterinary long-acting compound doxycycline injection and preparation method thereof

A technology of doxycycline and doxycycline hydrochloride, which is applied in the field of veterinary long-acting compound doxycycline injection and its preparation, can solve the problem of low florfenicol and doxycycline content and difficulty in achieving quick-acting , can not achieve high-efficiency results and other problems, to achieve the effect of improving the antibacterial effect, ensuring long-term effect, and light color of the finished product

Active Publication Date: 2011-08-10
镇江益生堂水产生物有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main drug is doxycycline hydrochloride; the additives are antioxidants, metal complexing agents and solvents for injection. This technical solution solves the problem of long-acting doxycycline, but it is difficult to achieve the purpose of quick-acting; the publication number is CN1861084A The compound florfenicol injection, the content of florfenicol and doxycycline is very low, can not achieve high

Method used

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  • Veterinary long-acting compound doxycycline injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] (1) Take 35ml of propylene glycol, 10ml of water for injection, add 0.9g of magnesium oxide, 0.2g of sodium thiosulfate, and stir well;

[0014] (2) Add 11.7 grams of doxycycline hydrochloride to the solution (1), heat up to 60-70°C for reaction while stirring, slowly adjust the pH value to 6.0-6.5 with ethanolamine during the complexation reaction, and keep the reaction for 30 minutes to The solution is clear and transparent doxycycline solution.

[0015] (3) Take 20ml of dimethylacetamide, add 0.6 or 2.0 grams of trimethoprim, or 4 or 5 grams of trimethoprim, and stir until completely dissolved to obtain a trimethoprim solution;

[0016] (4) Add the trimethoprim solution into the doxycycline solution, stir evenly, adjust the pH value to 6.0, and add water for injection to 100ml;

[0017] (5) Filter with a titanium rod or filter membrane, pack into ampoules or vials, and get the finished product after sterilization.

Embodiment 2

[0019] (1) Take 35ml of propylene glycol, 12ml of water for injection, add 8.8g of magnesium chloride or 1.80g of zinc oxide, 0.4g of sodium formaldehyde sulfoxylate, and stir well;

[0020] (2) Add 23.5 grams of doxycycline hydrochloride to the solution (1), heat up to 50-60°C for reaction while stirring, slowly adjust the pH value to 5.5-6.0 with triethanolamine during the complexation reaction, and keep it warm for 25 minutes Until the solution is clear and transparent doxycycline solution.

[0021] (3) Take 25ml of dimethylacetamide, add 4.0 or 5.0 grams of trimethoprim, and stir until completely dissolved to obtain a trimethoprim solution;

[0022] (4) Add the trimethoprim solution into the doxycycline solution, stir evenly, adjust the pH value to 6.5, and add water for injection to 100ml;

[0023] (5) Filter with a titanium rod or filter membrane, pack into ampoules or vials, and get the finished product after sterilization.

Embodiment 3

[0025] (1) Take 40ml of propylene glycol, 6ml of water for injection, add 1.75g ​​of magnesium oxide, 2.52g of calcium oxide or 3.60g of zinc oxide, and 0.2g of sodium thiosulfate, and stir well;

[0026] (2) Add 23.6 grams of doxycycline hydrochloride to the solution (1), heat up to 65-75°C while stirring, and slowly adjust the pH value to 6.0-6.5 with ethanolamine during the complexation reaction, and keep it warm for 60 minutes to The solution is clear and transparent doxycycline solution.

[0027] (3) Take 30ml of dimethylacetamide, add 4.0g or 5.0g of trimethoprim, and stir until completely dissolved to obtain a trimethoprim solution;

[0028] (4) Add the trimethoprim solution into the doxycycline solution, stir evenly, adjust the pH value to 6.0, and add water for injection to 100ml;

[0029] (5) Filter with a titanium rod or filter membrane, pack into ampoules or vials, and get the finished product after sterilization.

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Abstract

The invention relates to a veterinary long-acting compound doxycycline injection, which consists of doxycycline or doxycycline hydrochloride which serves as a main medicament, a synergist, a solvent, a complexing agent, an antioxidant and a PH regulator, wherein the weight of the doxycycline or the doxycycline hydrochloride which serves as the main medicament is between 10.0 and 20.0 grams based on the weight of the doxycycline; the synergist is 0.2 to 5 grams of trimethoprim or 0.2 to 5 grams of astragalus polysaccharide or a combination of the trimethoprim and the astragalus polysaccharide; a molar ratio of the complexing agent to the doxycycline is (1.00-1.10):1.00; the using amount of the antioxidant is between 0.10 and 1.00; and the solvent for the used injection is 100 milliliters after being added, and is water for the injection, propylene glycol, alpha-pyrrolidone, N methyl-pyrrolidone, dimethylformamide, dimethylacetylamide and a combination thereof. In the veterinary long-acting compound doxycycline injection, the curative effect of the injection is improved by the trimethoprim serving as the medicinal intensifier, and the astragalus polysaccharide has the effects of resisting virus and enhancing immunity.

Description

technical field [0001] The invention belongs to the field of veterinary injection medicines, in particular to a veterinary long-acting compound doxycycline injection and a preparation method thereof. Background technique [0002] Doxycycline (Doxycycline), also known as deoxyoxytetracycline, molecular formula C 22 h 24 N 2 o 8, The molecular weight is 444.40. It is a semi-synthetic broad-spectrum antibiotic with the same antibacterial spectrum as tetracycline, but its in vivo and in vitro activities are stronger than other tetracyclines such as oxytetracycline. Its injection is widely used in the prevention and treatment of various livestock and poultry diseases. Complexing it with metal ions can prolong the action time of the drug to achieve the purpose of long-term effect, and can also improve the pH value and stability, thereby improving the curative effect, and has broad development and application prospects. Most of the long-acting doxycycline injections currently o...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/65A61K31/715A61P31/04A61K31/505
Inventor 黄文江杨庆张建新戴荣贵孔令娣
Owner 镇江益生堂水产生物有限公司
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