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Method for preparing premix for medicament sugar-coating

A production method and sugar-coating technology are applied in the directions of pharmaceutical formulations, inactive medical preparations, inactive high molecular compounds, etc., and can solve the problems of increasing production cost, prolonging production cycle, and long process, and reducing the The effect of energy consumption, improving production efficiency, and easy process learning

Active Publication Date: 2011-09-21
安阳天助药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For a long time, sugar-coated tablets have won the favor of the majority of patients because of their convenience in taking and stable quality. However, this coating process is long and time-consuming. The weight of the drug increases by about 50-100%, and it takes 10-12 coating days. Hours, high energy consumption, high scrap rate, which not only prolongs the production cycle but also increases the production cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0006] Example 1. Take 100kg of raw material sucrose, 50kg each of gelatin and hypromellose, 70kg each of talc and β-cyclodextrin, 10kg each of coloring matter, Sichuan wax, glycerin, and Tween-80, and then put all the raw materials into 760kg Mixed evenly in purified water to form a premix. When in use, the liquid is evenly coated on the solid surface of the medicine, and dried with hot air layer by layer. Requirements for main raw materials: glycerin content ≥ 99.9%, density 1.26g / cm 3 ; Gelatin meets the QB 2354-2005 standard; sucrose contains C 12 h 22 o 11 62.5-91.5%; Sichuan wax density 0.950-0.970g / cm 3 , melting point 80-85°C, acid value 0.2-1.5, iodine value 1.4, saponification value 70-93; β-cyclodextrin content > 96.0-102.0%, pH value (PH value) 5.0-8.0, loss on drying ≤ 14.0%, The total number of bacteria (unit / g)≤1000, the total number of mold (unit / g)≤100; hypromellose methoxyl content 19.0-30.0%, hydroxypropyl content 4.0-12.0%; talcum powder fineness 325 m...

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PUM

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Abstract

A method for preparing a premix for medicament sugar-coating relates to a pharmaceutic adjuvant, especially to a coating premix for covering the medicament bitter taste, increasing the medicament stability and improving the tablet appearance. The raw materials of the premix for making medicament sugar-coating include cane sugar, gelatin, talcum, pigment, glycerin and tween-80 and the like. The raw materials are prepared according to a certain weight ratio and mixed with purified water to produce the premix for medicament sugar-coating. The beneficial effects of the method provided by the invention are as follows: the adjuvant amount can be saved, the medicine weight is gained by only 10-30% after being coated and the energy consumption is minimized; the production efficiency is raised; coating time is only 3-5 hours; the percent defective is reduced; the coloring is uniform and consistent during the coating process and the color is stable during the storage process of coated tablets; and the novel technology provided by the invention is easy to learn and operate and can be used to coat tablets of different sheet types and tablets having abnormal forms.

Description

technical field [0001] The invention relates to a pharmaceutical auxiliary material, in particular to a coating premix which can cover the bitter taste of the medicine, increase the stability of the medicine and improve the appearance of the tablet. technical background [0002] As the earliest coating type, sugar coating has been widely used at home and abroad. After coating, it can mask the bad smell of tablets, increase drug stability, and improve the appearance of tablets. In particular, Chinese patent medicines can be shielded from light and moisture by coating, which can effectively improve their bad smell and facilitate swallowing. For a long time, sugar-coated tablets have won the favor of the majority of patients because of their convenience in taking and stable quality. However, this coating process is long and time-consuming. The weight of the drug increases by about 50-100%, and it takes 10-12 coating days. Hours, high energy consumption, high scrap rate, not on...

Claims

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Application Information

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IPC IPC(8): A61K47/44A61K47/26A61K47/42A61K47/02A61K47/10A61K47/34A61K47/38A61K47/40
Inventor 伦西全赵长友刘晓昆刘玉清段友朋
Owner 安阳天助药业有限责任公司