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Method for preparing fatty acid phytosterol esters

A technology of phytosterol ester and phytosterol, which is applied in the preparation of steroids, food preparation, chemical instruments and methods, etc., can solve the problems of high demand pressure, complex catalyst preparation, and great influence on catalytic effect.

Active Publication Date: 2011-09-21
丰益生物科技(江苏)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] US5908946 discloses a kind of preparation method of monobasic fatty acid ester, selects catalyst as ZnAl 2 SO 4 , xZnO, yAl 2 o 3 etc., the temperature is 170°C-250°C, preferably at 225°C-230°C under pressurized reaction of 10-100bar. It is particularly mentioned that the preparation of the catalyst is complicated, and the ratio of zinc oxide has a great influence on the catalytic effect. The zinc oxide in the catalyst The content needs to be at least 10%, and the effect is better when there is 20%, and the effect is better if the content of zinc oxide reaches 30%, but the esterification rate is only 80% to 85%.
The method is under great pressure and requires high equipment

Method used

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  • Method for preparing fatty acid phytosterol esters
  • Method for preparing fatty acid phytosterol esters
  • Method for preparing fatty acid phytosterol esters

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preparation example Construction

[0093] In the method for preparing fatty acid phytosterol esters of the present application, the fatty acid and phytosterol can be heated first to form a uniform oily substance. It can be heated by conventional technical means. For example, depending on the selected fatty acids and phytosterols, the heating temperature may vary from, for example, about 100-180°C, 110-150°C, 110-130°C.

[0094] The phytosterols suitable for each method of the present application may include one or a mixture of more than one of sitosterol, stigmasterol, campesterol, and brassicasterol in any proportion. Preferred is β-sitosterol, or a mixture of several sterols. For example, the phytosterol suitable for each method of the present application may be a mixture of β-sitosterol, stigmasterol, campesterol or brassicasterol in any proportion. For example, based on the total weight of the mixture, the mixture contains 40-50% β-sitosterol, 20-28% stigmasterol, 20-28% campesterol and 0.5-5% brassicaste...

Embodiment 1～21

[0140] Embodiment 1~21: the preparation of sterol ester

[0141] By the molar ratio shown in table 1, phytosterol (the mixed sterol of 43.48% β-sitosterol, 25.06% stigmasterol, 25.90% campesterol, 1.01% brassicasterol, this mixed sterol purity is 95.45%) and oleic acid are added Put it into a clean and dry three-neck flask, heat it to 130°C, and continue heating until it becomes a uniform oily substance. Then, add the catalyst in the amount shown in Table 1, be heated to the reaction temperature shown in Table 1, and the whole process remains in a vacuum and stirring state until the reaction is completed, and the degree of completion can be monitored by HPLC.

[0142] Table 1: Contents of sterol esters and free sterols after esterification under different reaction conditions

[0143]

[0144]

Embodiment 22

[0146] About 200 g of the reaction solution obtained by the esterification operation in Example 14 was cooled to 100° C., the catalyst was filtered off while hot, and 195 g of the filtrate was collected for purification.

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Abstract

The invention relates to a method for preparing fatty acid phytosterol esters, which comprises the following step of: esterifying fatty acid and phytosterol in the presence of one or more catalysts such as alumina, aluminum hydroxide, aluminum salt (such as aluminum chloride, aluminum sulfate, aluminum silicate and the like), oxide of other elements in IIIA family, phosphorus pentoxide, phosphoric acid, phosphate (such as sodium dihydrogen phosphate, dipotassium phosphate and the like), a molecular sieve and silica gel in effective catalysis amount. The invention also relates to the fatty acid phytosterol esters prepared by the method, and foods, soft capsules and cosmetics containing the phytosterol esters.

Description

technical field [0001] The application relates to the preparation of fatty acid phytosterol esters, and foods, soft capsules and cosmetics containing fatty acid phytosterol esters. Background technique [0002] Phytosterols are the basic chemical components of plants, including β-sitosterol, brassicasterol, stigmasterol, campesterol, etc. Their structures are very similar, and they all contain a steroid nucleus, and there is a hydroxyl group at the 3-position of the steroid nucleus. Under certain conditions, sterols can react with fatty acids and their esters to form phytosterol esters. [0003] Phytosterols can inhibit the intake of food cholesterol and bile cholesterol by replacing cholesterol, thereby achieving the effect of lowering serum cholesterol, but a relatively large defect of free sterols limits its wide-scale use, that is: phytosterols are almost insoluble in water, The solubility in oil is also very small, generally its solubility is less than 2% at 40°C, and ...

Claims

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Application Information

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IPC IPC(8): C07J75/00A23L1/30A61K8/63A61Q19/00
Inventor 郭涛姜元荣王勇
Owner 丰益生物科技(江苏)有限公司
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