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Artificial tear containing polyacrylic acid and sodium hyaluronate and preparation method thereof

A technology of sodium hyaluronate and artificial tears, which is applied in the field of medicine, can solve problems such as corneal epithelial cell damage, and achieve the effect of reducing damage, improving bioavailability, and increasing viscosity

Inactive Publication Date: 2011-09-28
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Long-term use of artificial tears containing preservatives will cause some degree of damage to corneal epithelial cells

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Under the 100-level environment, dissolve 0.60g of polyacrylic acid and 0.10g of sodium hyaluronate in deionized water and mix to obtain a mixed solution; add 1.30g of glycerol, 0.01g of mannitol, and 0.08g of vitamin E and mix well; add 0.01g sodium bicarbonate to adjust pH value, add 1.00g glucose, 9.00g sodium chloride, 0.14g potassium chloride and 0.05g sodium bicarbonate to adjust osmotic pressure; add deionized water to 1000mL, filter with 0.2 μm microporous membrane Artificial tears are obtained after sterilization.

Embodiment 2

[0039] Under the 100-level environment, dissolve 0.60g of polyacrylic acid and 0.20g of sodium hyaluronate in deionized water and mix to obtain a mixed solution; add 1.30g of glycerol, 0.01g of sorbitol, and 0.05g of vitamin E and mix well; add 0.05g sodium bicarbonate to adjust the pH value, add 1.00g glucose, 9.00g sodium chloride, 0.14g potassium chloride and 0.05g sodium bicarbonate to adjust the osmotic pressure; add deionized water to 1000mL, sterilize with high pressure steam Get artificial tears.

Embodiment 3

[0041] In a hundred-level environment, dissolve 3.50g of polyacrylic acid and 1.00g of sodium hyaluronate in deionized water and mix to obtain a mixed solution; add 3.80g of glycerol, 0.06g of sorbitol, and 0.01g of vitamin E to mix well; add 0.20g sodium bicarbonate to adjust pH value, add 1.00g glucose, 9.00g sodium chloride, 0.14g potassium chloride and 0.05g sodium bicarbonate to adjust osmotic pressure; add deionized water to 1000mL, filter with 0.2 μm microporous membrane Artificial tears are obtained after sterilization.

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Abstract

The invention discloses an artificial tear containing polyacrylic acid and sodium hyaluronate and a preparation method thereof. The artificial tear disclosed by the invention comprises polyacrylic acid, sodium hyaluronate, thickener, stabilizer, antioxidant, pH regulator, osmoregulator and de-ionized water. Based on the viscous synergetic effect generated by the combination of the polyacrylic acid and the sodium hyaluronate, the invention improves the bioavailability of the medicament and simultaneously reduces the total amount of polymers in the formula, thereby lowering the material cost, effectively reducing the in vivo retention volume of the polymers and enhancing the safety of the product. The artificial tear is prepared by a sterile operation process, thereby ensuring the sterile performance of the product, and enabling the product to be safer, more reliable, more convenient and more sanitary.

Description

technical field [0001] The invention belongs to the technical field of medicines, and relates to an ophthalmic medicine and a preparation method thereof, in particular to artificial tears containing polyacrylic acid and sodium hyaluronate and a preparation method thereof. Background technique [0002] Dry eye, also known as keratoconjunctival sicca (abbreviation: KCS), is one of the most common ophthalmic diseases. A general term for a variety of conditions characterized by facial discomfort and ocular surface lesions. The etiology of dry eye is various, and the pathological process is complicated. Dry eye syndrome includes a wide range of diseases, mainly manifested as stinging eyes, dryness, foreign body sensation, itching, red eyes, photophobia, tearing, etc. If not treated in time, it will cause corneal clouding, ulcers, vision loss, and even blindness and other serious consequences. [0003] The current drug treatment of dry eye is mainly artificial tear replacement ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/78A61K31/728A61P7/04
Inventor 魏坤张捷
Owner SOUTH CHINA UNIV OF TECH
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