Preparation method of vitamin A microcapsules

A vitamin and microcapsule technology is applied in the field of preparation of vitamin A microcapsules, which can solve the problems of vitamin A destruction and poor emulsification efficiency, and achieve the effects of short emulsification time, low temperature, and improved oxygen barrier and antioxidant capacity.

Inactive Publication Date: 2011-09-28
何德海
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Using the above-mentioned high-gravity rotary packed bed emulsifier, its emulsification efficiency is not as good as that of a high-shear emulsifier; in addition, if the water used in emulsification is not deoxidized, vitamin A will be destroyed during the preparation process

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Operate the oil melting pot in an anaerobic state in advance, that is, evacuate, the vacuum degree reaches above -0.9Mpa, close the vacuum valve, and replenish nitrogen to normal pressure. After repeating the operation three times, open the feeding port, slightly open the nitrogen, and add 50KG of vitamin A and 25g of natural VE oil. Close the feed port, evacuate and fill the vacuum with nitrogen in one go. Turn on stirring and heat to an internal temperature of 55°C. Slightly open the nitrogen, open the feeding port, add chitosan 0.05kg, and stir for 45 minutes. Filtrate through a disc filter while hot to obtain a vitamin A oil solution.

[0021] 250kg of purified water was deoxidized by thermal spray, added to the deoxygenated dissolving pot, and then 100kg of national starch, model HI-CAP100, was added to form a 40% neoalkenyl succinic starch ester solution. After the dissolving pot is deoxygenated again, it is heated to dissolve. The dissolution temperature is 5...

Embodiment 2

[0024] Operate the oil melting pot in an anaerobic state in advance, that is, evacuate, the vacuum degree reaches above -0.9Mpa, close the vacuum valve, and replenish nitrogen to normal pressure. After repeating the operation three times, open the feeding port, slightly open the nitrogen, and add 50KG of vitamin A and 50g of natural VE oil. The feed port was closed, and the vacuum was drawn and filled with nitrogen again. Turn on stirring and heat to an internal temperature of 55°C. Slightly open the nitrogen, open the feeding port, add chitosan 0.025kg, and stir for 45 minutes. Filtrate through a disc filter while hot to obtain a vitamin A oil solution.

[0025] 330kg of purified water was deoxidized by thermal spray, added to the deoxygenated dissolving pot, and then 150kg of national starch, model HI-CAP100, was added to form a 45% neoalkenyl succinic starch ester solution. After the dissolving pot is deoxygenated again, it is heated to dissolve. The dissolution tempera...

Embodiment 3

[0028] Operate the oil melting pot in an anaerobic state in advance, that is, evacuate, the vacuum degree reaches above -0.9Mpa, close the vacuum valve, and replenish nitrogen to normal pressure. After repeating the operation three times, the feeding port was opened, the nitrogen gas was slightly opened, and 50KG of vitamin A and 250g of natural VE oil with a tocopherol content of 50% were added. Close the feed port, evacuate and fill the vacuum with nitrogen in one go. Turn on stirring and heat to an internal temperature of 55°C. Slightly open the nitrogen, open the feeding port, add chitosan 0.25kg, and stir for 45 minutes. Filtrate through a disc filter while hot to obtain a vitamin A oil solution.

[0029]400kg of purified water was deoxidized by thermal spray, added to the deoxygenated dissolving pot, and then 200kg of national starch, model HI-CAP100, was added to make a 50% neoalkenyl succinic starch ester solution. After the dissolution pot is deoxygenated again, it...

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Abstract

The invention relates to a preparation method of more stable vitamin A microcapsules, comprising the following steps of: firstly, preparing a vitamin A oil solution containing an antioxidant from vitamin A and the antioxidant in the absence of oxygen, adding chitosan and stirring evenly, after stirring fully, filtering and removing the chitosan to obtain the vitamin A oil solution; adding octenyl succinic acid modified starch to purified water deaerated by a thermal spray deaerator, heating for dissolution; mixing the prepared octenyl succinic acid modified starch solution and the vitamin A oil solution in a certain proportion, emulsifying quickly by an on-line emulsifying machine, and instantly cooling by a cooler; and performing hot air spray drying on the emulsion to obtain stable vitamin A microcapsules. The storage life of the product prepared in the invention reaches two years.

Description

technical field [0001] The invention relates to a preparation process of stable vitamin A microcapsules, and relates to a preparation method of vitamin A microcapsules which adopts rapid emulsification and instant cooling of emulsion. Background technique [0002] Vitamin A is a substance necessary to maintain human growth, development, reproduction and the stability of cell membranes. Vitamin A is sensitive to low light and is related to dark vision. When it is deficient, it can lead to night blindness. It can maintain the integrity and soundness of the epithelial tissue structure. , urinary tract and reproductive system epithelium are significantly affected; long-term lack of vitamin A, lacrimal gland epithelium is not perfect, tears decrease, can develop dry eye disease and corneal softening, with corneal perforation, and finally blindness; vitamin A can also promote normal growth, lack of When the bone growth is poor, the growth and development are hindered, and the rep...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K31/07A61K47/22A61P3/02
Inventor 何德海
Owner 何德海
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