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Method for extracting ceramide-rich lipid from byproducts of agriculture and forestry by supercritical extraction technology

A technology of ceramide and extraction technology, which is applied in the field of extracting ceramide-rich lipids in agricultural and forestry by-products, can solve the problems of environmental pollution by separation materials, high impurities in ceramides, and energy consumption for solvent recovery, so as to avoid chlorine-containing by-products. Solvent, extraction rate improvement, anti-oxidation and fugitive effects

Inactive Publication Date: 2011-09-28
ZHEJIANG UNIV
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AI Technical Summary

Problems solved by technology

[0007] In the prior art, the solvent method is mostly used to prepare ceramide-rich lipids from agricultural and forestry by-products as raw materials, which has the advantages of low extraction rate, cumbersome steps, high impurities in ceramide lipids, energy-consuming solvent recovery, and pollution of separation materials. Environmental and other disadvantages

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Step 1: Dry the waste from rice bran processing, the crushed mesh is less than 1mm, weigh the processed agricultural and forestry by-products and place them in the extraction kettle of supercritical extraction equipment, close the extraction kettle, and pass through CO 2 , to control temperature and pressure;

[0033] Step 2: During the operation of the supercritical extraction equipment, control the temperature at 60-100°C, control the pressure at 10-30MPa, and control the time at 1-3 hours; during this period, add 10-20% methanol and ethanol as entraining agents;

[0034] Step 3: Then obtain the extract and spun to dryness to obtain active lipid 1 rich in ceramide;

[0035] Step 4: Add ceramide-rich lipid 1 to 0.1-0.5mol / L sodium methoxide solution, the weight ratio of ceramide-rich lipid 1: sodium methoxide solution is 1:80-150, stir at room temperature 5 to 24 hours, after the alkali treatment is completed, the reaction solution is rotary evaporated to dryness, and...

Embodiment 2

[0038] According to the preparation steps and method of Example 1.

[0039] 100 grams of processed wheat bran, the crushed particle size is less than 1mm, put in the extraction kettle of supercritical extraction equipment, close the extraction kettle, and pass CO 2 , control temperature, pressure, in the operation of supercritical extraction equipment, control temperature 60 ℃, pressure control at 20MPa, time control at 2 hours, add the methanol of 10% entraining agent during, obtain extraction liquid then, CO 2 Quickly separate from the extract, and then spin evaporate to dryness to obtain ceramide-rich active lipid 1. Add ceramide-rich lipid 1 to 0.35mol / L sodium methoxide solution 100mL, stir at room temperature for 10h, and the alkali treatment is completed Finally, the reaction solution was rotary evaporated to dryness to obtain lipid 2 rich in ceramide, lipid 3 rich in ceramide separated by high performance liquid chromatography, NMR, ESI-MS, and analyze its structure, ...

Embodiment 3

[0041] According to the preparation steps and method of Example 1.

[0042] 100 grams of processed corn processing waste, the crushed particle size is less than 1mm, placed in the extraction kettle of supercritical extraction equipment, the extraction kettle is closed, and CO 2 , control temperature, pressure. In the operation of the supercritical extraction equipment, the temperature is controlled at 100°C, the pressure is controlled at 25MPa, and the time is controlled at 1.5 hours; during this period, 10% ethanol as an entrainer is added to obtain the extract, CO 2 Quickly separated from the extract, and then spun to dryness to obtain active lipid 1 rich in ceramide. Add lipid 1 rich in ceramide to 100 mL of 0.4 mol / L potassium hydroxide solution, stir at room temperature for 15 h, and treat with alkali After completion, the reaction solution was spun to dryness to obtain lipid 2 rich in ceramide, lipid 3 rich in ceramide separated by high performance liquid chromatography...

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Abstract

The invention relates to a method for extracting ceramide-rich lipid by adopting a green supercritical extraction technology and taking cheap byproducts of agriculture and forestry raw materials, and the method has unlimited market potential and values of ecological and environment friendliness. During the operation of supercritical extraction equipment, temperature is controlled to 60 to 100 DEG C, pressure is controlled to 10 to 30 MPa, and time is controlled to 1 to 3 hours; during the operation, 10-20% methanol and ethanol as entrainers are added, and then extract liquid is obtained, and is rotated and evaporated to dryness to obtain the ceramide-rich active lipid; and after alkali treatment, ceramide is separated by high-efficiency liquid chromatography. The method disclosed by the invention belongs to a green technology, has the advantages of high extraction yield, simplified separation steps and low cost, and simultaneously can be used for obtaining ceramide lipid in different contents.

Description

technical field [0001] The invention relates to the field of green preparation of active compounds from agricultural and forestry by-products through supercritical extraction technology, in particular to a method for extracting ceramide-rich lipids from agricultural and forestry by-products. Background technique [0002] Agricultural and forestry by-products can be used as renewable organic biological resources for different compound products required by human beings, which can help alleviate the world resource crisis and solve the problem of raw materials for future organic products. [0003] Ceramide has been researched to determine that its characteristic effect is its water-holding capacity, which is due to the hydrophilic group contained in the structure of ceramide, which has a good affinity for water. It is known as the "king of hydration" and is transparent 16 times the moisturizing effect of hyaluronic acid. Especially for aging dry skin, the effective rate of mois...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61K36/00C07C233/20A61P1/16A61P31/12A61P35/00A61P37/04
CPCY02P20/544Y02P20/54
Inventor 崔艳丽孔万平陈晨毛建卫
Owner ZHEJIANG UNIV
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