Degradable Mg-Zn-Y-Ca intravascular stent material and preparation method thereof

A vascular stent and alloy technology, applied in the field of degradable Mg-Zn-Y-Ca vascular stent material and its preparation, can solve problems such as organ damage and disorder, achieve improved corrosion resistance, strength and plasticity, and inhibit The effect of battery formation

Inactive Publication Date: 2011-10-05
TAIYUAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, if the commercial magnesium alloy contains a certain amount of Al, once the stent is placed in the body, the Al element can cause organ damage and cause symptoms such as osteomalacia, anemia, and neurological disorders.

Method used

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  • Degradable Mg-Zn-Y-Ca intravascular stent material and preparation method thereof
  • Degradable Mg-Zn-Y-Ca intravascular stent material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0027] Step 1. Fusion of master alloy ingots

[0028] I. Preliminary preparation

[0029] The raw materials needed for this test are: 1 # Magnesium Ingot, 1 # Zinc ingots, 99.9% pure yttrium and Mg-30% Ca master alloy;

[0030] In order to prevent the oxidation and combustion of magnesium alloys, a protective gas has been passed throughout the melting process. The protective gas used in this test is a mixed gas of carbon dioxide and sulfur hexafluoride, and the flow ratio of carbon dioxide and sulfur hexafluoride is 99%. : 1;

[0031] II. Specific operation process

[0032] a. Set 1 # Magnesium Ingot, 1 #Zinc ingots, 99.9% pure yttrium and Mg-30% Ca master alloy are calculated by mass percentage Wt%: Zn 1.00, Y 0.10, Ca 0.01, and the rest is the proportioning requirement of Mg, and the raw materials are weighed for later use;

[0033] b. Put the crucible into the resistance furnace, and at the same time pass the mixed gas of carbon dioxide and sulfur hexafluoride into t...

Embodiment approach 2

[0040] The composition ratio of magnesium alloy changes as follows: 1 # Magnesium Ingot, 1 # Zinc ingot, 99.9% pure yttrium and Mg-30% Ca master alloy are calculated by mass percentage Wt%: Zn 2.00, Y 0.40, Ca 0.15, the rest is Mg, and others are the same as Embodiment 1.

[0041] The magnesium alloy obtained under this process has a yield strength of 225MPa, an elongation of 22%, and a corrosion rate of 0.25mm / a in a dynamic simulated body fluid, meeting the performance requirements of an ideal vascular stent.

Embodiment approach 3

[0043] The composition ratio of magnesium alloy changes as follows: 1 # Magnesium Ingot, 1 # Zinc ingot, 99.9% pure yttrium and Mg-30% Ca master alloy are calculated by mass percentage Wt%: Zn 3.00, Y 0.70, Ca 0.35, the rest is Mg, and others are the same as Embodiment 1.

[0044] The magnesium alloy obtained under this process has a yield strength of 240MPa, an elongation of 20%, and a corrosion rate of 0.28mm / a in a dynamic simulated body fluid, meeting the performance requirements of an ideal vascular stent.

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Abstract

The invention relates to a degradable Mg-Zn-Y-Ca intravascular stent material and a preparation method thereof, which belong to the fields of design and manufacture of metal materials. The intravascular stent material is characterized by comprising the following chemical components in percentage by weight (wt%): Zn 1.00 to 4.00, Y 0.10 to 1.00, Ca 0.01 to 0.50 and the balance of Mg; the chemical components are subjected to sub-rapid solidification at (200+ / -10) K / S and heat treatment of heating at 320 to 420 DEG C and heat preservation for 20 to 30h; and the texture characteristic of the intravascular stent material is that: even and fine spherical quasicrystalline phases Mg3YZn6 are dispersed and distributed on an alpha-Mg matrix. The potential difference between the spherical quasicrystalline phases Mg3YZn6 and magnesium is lower so that the formation of a galvanic cell is restrained and galvanic corrosion is alleviated; the sphericity quasicrystal Mg3YZn6 has good corrosion resistance and can obviously enhance the corrosion resistant performance of magnesium alloy; and at the same time, the quasicrystal also has the characteristics of high hardness, low friction coefficient, low interface energy and the like and can greatly enhance the mechanical performance of the magnesium alloy.

Description

technical field [0001] The invention discloses a degradable Mg-Zn-Y-Ca vascular stent material and a preparation method thereof, belonging to the field of design and preparation of metal materials. Background technique [0002] Metal vascular stent materials are mainly divided into two categories: non-degradable vascular stent materials and degradable vascular stent materials. 316L stainless steel is currently a commonly used non-degradable vascular stent material in clinical practice. It has good mechanical properties and excellent corrosion resistance. However, due to the ferromagnetism of stainless steel, it cannot be used for magnetic resonance imaging, and it does not have MRI visibility, which affects its angiography. In addition, the stainless steel stent is a permanent stent and cannot be degraded in the body, so it inevitably has common problems with permanent stents, including long-term vascular intimal dysfunction, delayed vascular endothelialization, thrombogeni...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22C23/04C22C23/06B22D27/04B22D27/15A61L31/02
Inventor 许春香刘燕萍余春燕郝爱萍冯弘张金山王文先
Owner TAIYUAN UNIV OF TECH
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