Green extraction process for artemisinin

Abstract

The invention discloses a green extraction process for artemisinin, and relates to the field of drug production. The process comprises the following steps: (1) drying of raw materials, that is, putting the raw materials into drying equipment for drying; (2) primary processing of artemisinin, that is, putting the dried raw materials into an extraction tank, adding petroleum ether, heating the extraction tank, carrying out countercurrent extraction, allowing the extract to flow out from the extraction tank, standing the extract to obtain a supernatant, allowing the supernatant to pass through asilica gel column, eluting the silica gel column with petroleum ether, collecting artemisinin fractions, putting the artemisinin fractions into a concentrating tank for concentration until crystals are precipitated, putting the obtained concentrate into a crystallizing tank for crystallization, carrying out filtering to obtain crystals, and drying the crystals so as to obtain crude products of artemisinin; (3) refining of artemisinin, that is, dissolving the crude products of artemisinin in an alcohol precipitating tank with ethanol, wherein the ethanol with a concentration of 93 to 95% is 65to 75 times the amount of the crude products, standing the solution, taking the supernatant of the solution for secondary filter, concentrating the filtrate in the concentrating tank, standing the concentrate for crystallization, carrying out filtering to obtain crystals, and drying the crystals under vacuum so as to obtain refined products of artemisinin.

Description

technical field [0001] The invention relates to the field of medicine production, in particular to an artemisinin extraction process. Background technique [0002] Artemisin (artemisin) is an artemisinin drug extracted from the medicinal plant Artemisia annua L., which is a sesquiterpene lactone compound containing a peroxide group. It is the only internationally recognized herbal medicine in my country. The Chinese herbal medicine extract developed by western medicine is an anti-malarial raw material drug that the World Health Organization (WHO) clearly stipulates to replace quinine. my country's artemisinin production and sales account for more than 90% of the global production and sales, and China's extraction technology also represents the world's level. [0003] At present, the technology of extracting artemisinin from Artemisia annua in China is mainly the traditional organic solvent extraction and separation method, that is, using organic solvents such as ethanol, ace...

AI Technical Summary

Problems solved by technology

After entering the 1990s, supercritical carbon dioxide extraction technology began to be used to extract medicinal active ingredients from medicinal plants. It is reported that my country has also studied the supercritical fluid extraction of artemisinin, but in the end, this method has a large investment in equipment and production. The shortcomings of low capacity, high operating costs, and lack of market competitiveness have not yet carried out large-scale industrial production at home and abroad.