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Sea cucumber saponin-containing composition and its application in foods and drugs

A technology of sea cucumber saponins and sea cucumber total saponins, which is applied in functional compositions and its application fields in food and medicine, can solve the problems of late functional activity, achieve simple steps, prevent or treat type II diabetes, and reduce fasting blood sugar levels Effect

Inactive Publication Date: 2011-10-26
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Saponin is an important active ingredient in sea cucumber, but the research on its functional activity started late, and its beneficial regulatory function urgently needs to be explored

Method used

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  • Sea cucumber saponin-containing composition and its application in foods and drugs
  • Sea cucumber saponin-containing composition and its application in foods and drugs
  • Sea cucumber saponin-containing composition and its application in foods and drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Embodiment 1: the preparation method of sea cucumber total saponins

[0052] In the first step, dried sea cucumbers purchased in the market are dried overnight in an oven at 80°C, and crushed to 20 mesh to obtain sea cucumber powder;

[0053] The second step is to weigh 1kg of sea cucumber powder, add 4L of 60% ethanol solution by mass percentage, heat and reflux for extraction at 80°C for 2 hours, filter, recover the filtrate, centrifuge the filtrate at 5000r / min for 15min, and keep the supernatant; Adding 3L mass percent to the extracted sea cucumber dregs is 60% ethanol solution, carries out heat reflux extraction with the above-mentioned same conditions, collects this supernatant, then adds 3L mass percent again in the extracted sea cucumber residues 60% ethanol solution, heat reflux extraction again under the same conditions as above, collect the supernatant this time, combine the supernatant obtained from the three times, this process consumes 10L of 60% ethanol s...

Embodiment 2

[0058] Example 2: The improvement effect of sea cucumber saponins on animal mice suffering from type II diabetes

[0059] 1. Materials and methods

[0060] The experimental animals were C57 / BL6 mice, male, weighing 22±0.5g, purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., license number: SCXK (Beijing) 2009-0007. The mice were randomly divided into 4 groups according to body weight: the normal control group, the model control group, the low-dose group of total sea cucumber saponins prepared in Example 1, and the high-dose group of total sea cucumber saponins prepared in Example 1, with 8 mice in each group, fed with corresponding feed.

[0061] The concrete formula of each group animal feed is shown in Table 1, wherein the protein content of normal control group feed is 20%, fat content is 5%, starch 65%, mineral matter and vitamin compound all refer to AIN-93 formula; And model control group feed The protein content is 20%, the fat content is 2...

Embodiment 3

[0084] Example 3: Capsules with sea cucumber saponin as the main component

[0085] Add the total sea cucumber saponins in Example 1 or a single type of sea cucumber holothurin A or echinoside A, 20 g of micropowder silica gel, 400 g of dextrin, and 530 starch. Make 1000 capsules. Each capsule contains 50mg of active ingredient sea cucumber saponin.

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Abstract

The invention provides a composition for preparation of foods or drugs for preventing, improving or treating type II diabetes. The composition comprises sea cucumber total saponins or a sea cucumber saponin. Results of animal experiments show that the sea cucumber total saponins or the sea cucumber saponin can reduce obviously a fasting blood glucose value and improve significantly an insulin resistance thus has obvious effects of improving, preventing or treating II type diabetes and can be utilized alone and adopted as a component or an auxiliary material to be prepared into foods or drugs.The preparation method of the sea cucumber saponin-containing composition has the advantages of low cost, simple processes and less pollution of organic solvents on environment. Results of an animal experiment show that the sea cucumber saponin-containing composition have good effects of improving, preventing or treating II type diabetes and can be utilized for development of foods or drugs for improving, preventing or treating II type diabetes.

Description

technical field [0001] The invention relates to a functional composition and its application in food and medicine, in particular to a composition containing sea cucumber saponin and its application in food and medicine. Background technique [0002] Diabetes mellitus is a metabolic disease of multiple etiologies characterized by chronic hyperglycemia accompanied by disturbances in carbohydrate, fat and protein metabolism due to defective insulin secretion. The disease is divided into type I diabetes (insulin-dependent diabetes) and type II diabetes (non-insulin-dependent diabetes). Among them, patients with type 2 diabetes account for about 90% of the total number of diabetic patients, and its incidence is increasing year by year with the development of social economy and changes in lifestyle. It has become the second serious threat to human health after cardiovascular and cerebrovascular diseases and tumors. Three major non-communicable diseases. According to statistics f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/29A23L1/333A61K35/56A61P3/10A23L33/00A23L17/50A61K35/616
Inventor 胡晓倩王玉明薛勇徐杰李兆杰常耀光唐庆娟王静凤薛长湖
Owner OCEAN UNIV OF CHINA
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