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Titanium nitride film modified artificial trabecular stent

A technology of beam stent and titanium nitride, which is applied in the field of artificial trabecular stent, can solve problems such as follicle rupture and low intraocular pressure, and achieve the effect of improving hydrophilicity, small contact angle, and reducing human body rejection

Inactive Publication Date: 2011-10-26
TIANJIN SHI JI KANG TAI BIOMEDICAL ENG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, none of the above methods can better prevent advanced fibrosis, and new complications such as follicular rupture and low intraocular pressure may occur

Method used

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  • Titanium nitride film modified artificial trabecular stent
  • Titanium nitride film modified artificial trabecular stent
  • Titanium nitride film modified artificial trabecular stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A titanium nitride thin film modified artificial trabecular support is provided with a titanium nitride thin film layer on the surface of the artificial trabecular support made of polymethyl methacrylate.

Embodiment 2

[0022] A preparation method of titanium nitride film modified artificial trabecular support, comprising the steps of:

[0023] (1) cleaning the artificial trabecular support with polymethyl methacrylate as material with purified water, and drying;

[0024] (2) Vacuum up to 0.5×10 -3 Pa, using a low-energy argon ion source to sputter and clean the artificial trabecular scaffold for 30 minutes; this is conducive to the degree of bonding between the scaffold and the film, increases the nucleation activity, and is also conducive to maintaining the smoothness of the film.

[0025] (3) Set the artificial trabecular support on the sample stage, start and rotate the sample stage, bombard the titanium target with a nitrogen ion source, and then sputter and deposit it on the surface of the artificial trabecular support to prepare a titanium nitride film Modified artificial trabecular stent, the sputtering parameter screen used is extremely 2kV, the beam current is 40mA, and the nitroge...

Embodiment 3

[0027] A preparation method of titanium nitride film modified artificial trabecular support, comprising the steps of:

[0028] (1) cleaning the artificial trabecular support with polymethyl methacrylate as material with purified water, and drying;

[0029] (2) Vacuum up to 0.8×10 -3 Pa, using a low-energy argon ion source to carry out sputter cleaning on the artificial trabecular support for 20 minutes;

[0030] (3) Set the artificial trabecular support on the sample stage, start and rotate the sample stage, bombard the titanium target with a nitrogen ion source, and then sputter and deposit it on the surface of the artificial trabecular support to prepare a titanium nitride film Modified artificial trabecular stent, the sputtering parameter screen used is extremely 1.9kV, the beam current is 30mA, and the nitrogen partial pressure is 1.2×10 -2 Pa, the time is 2.5h.

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Abstract

The invention discloses a titanium nitride film modified artificial trabecular stent, which is characterized by arranging a titanium nitride film on the surface of an artificial trabecular stent made of polymethyl methacrylate. By SEM scanning, the titanium nitride film formed on the surface of the modified artificial trabecular stent has the advantages of uniform and dense in structure, small particles, low roughness, small contact angle and high hydrophilcity relative to the uncoated artificial trabecular stent, and reducing the cytotoxicity of the artificial trabecular stent. The coated artificial trabecular stent has lower hemolysis rate than the uncoated artificial trabecular stent. The titanium nitride film modified artificial trabecular stent disclosed in the invention can improve the biocompatibility of the trabecular stent and the antifibrotic capacity, can be implanted into the surface to form a coating, can reduce the body rejection, further improve and reinforce the drainage effect of filtration surgery, and raise the success rate of surgery.

Description

technical field [0001] The invention belongs to the field of medical materials, and relates to an artificial trabecular support that can be implanted under the scleral flap during ophthalmic glaucoma filtration surgery. Background technique [0002] Glaucoma is a very harmful and common blinding eye disease. Trabeculectomy is currently the most commonly used filtering surgery for glaucoma. Its purpose is to establish a new drainage channel for aqueous humor and reduce intraocular pressure. However, after the operation, the filter port is often blocked due to fibrosis, and the intraocular pressure rises again, resulting in the failure of the operation. Therefore, the ophthalmology field has been exploring new surgical methods and seeking anti-fibrosis measures. The current solutions include implanting an intraocular pressure regulating valve with a catheter or a so-called artificial trabecula in the anterior chamber, implanting silica gel, collagen, and sodium hyaluronate bi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/30A61L27/16
Inventor 李笑涵
Owner TIANJIN SHI JI KANG TAI BIOMEDICAL ENG CO LTD