Nano-suspension for silybin-phospholipid complex and preparation method thereof
A technology of nanosuspension and lecithin phospholipid, applied in the field of medicine, can solve the problem of no nano preparation and the like, and achieve the effects of improving clinical curative effect, high dissolution rate and improving bioavailability
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Embodiment 1
[0038] Co-dissolve equimolar silibinin and refined egg yolk lecithin in hot acetone, keep warm at 55°C for 2 hours, concentrate to a thick paste, quickly add n-hexane, filter, dry the filter cake and pulverize to obtain silybin phospholipid Compound: take 0.25g silibinin phospholipid complex, add appropriate amount of ethanol or acetone to dissolve after heating, slowly inject into water and ultrasonically, concentrate under reduced pressure to remove ethanol, then inject into water containing 0.25g hydroxypropyl cellulose, Mix and stir evenly, add water to 100mL, obtain a milky-white nano-suspension with a bluish opalescence, put it on a high-pressure homogenizer, and cycle 10 times at 20K Psi to obtain a silibinin phospholipid complex nano-suspension. It is also possible to add mannitol with a weight ratio of 20% as a freeze-drying protective agent, pre-freeze in a refrigerator at -80°C for 48h, and freeze-dry in a freeze dryer: temperature -48°C, pressure 0.1mbar, take it ou...
Embodiment 2
[0041]Co-dissolve equimolar silibinin and refined egg yolk lecithin in hot acetone, keep warm at 55°C for 2 hours, concentrate to a thick paste, quickly add n-hexane, filter, dry the filter cake and pulverize to obtain silybin phospholipid Compound: take 0.50g silibinin phospholipid complex, add appropriate amount of ethanol or acetone to dissolve after heating, slowly inject into water and ultrasonically, concentrate under reduced pressure to remove ethanol, and then inject into In the water of hydroxypropyl methylcellulose, mix and stir evenly, add water to 100mL, obtain the nano-suspension of milky white with slightly bluish opalescence, put it on a high-pressure homogenizer, and circulate 15 times under 30K Psi to obtain silibinin Phospholipid complex nanosuspension. It is also possible to add mannitol with a weight ratio of 10% as a freeze-drying protective agent, pre-freeze in a refrigerator at -80°C for 48h, and freeze-dry in a freeze dryer: temperature -48°C, pressure ...
Embodiment 3
[0044] Co-dissolve equimolar silibinin and soybean lecithin in hot acetone, keep warm at 55°C for 2 hours, concentrate to a thick paste, add n-hexane quickly, filter, dry the filter cake and pulverize to obtain silybin phospholipid complex Take 0.50g silibinin phospholipid complex, add appropriate amount of ethanol or acetone to heat and dissolve, slowly inject into water and ultrasonically, concentrate under reduced pressure to remove ethanol, and then inject into 0.50g hydroxypropyl cellulose, 1.0g polysaccharide In the water of Vitone K30, mix and stir evenly, add water to 100mL, get milky white with bluish opalescent nano primary suspension, put it on a high-pressure homogenizer, cycle 12 times at 30K Psi, get silibinin phospholipid complex nano suspension. You can also add mannitol with a weight ratio of 5% as a freeze-drying protective agent, pre-freeze in a refrigerator at -80°C for 48h, and freeze-dry in a freeze dryer: take it out after 48h at a temperature of -48°C a...
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