Preparation method of ginkgo leaf extract

A technology of Ginkgo biloba leaves and extract, applied in the field of preparation of Ginkgo biloba extract, can solve problems such as low product yield and unstable quality, and achieve the effects of improving quality and grade, improving production efficiency and being easy to implement.

Active Publication Date: 2011-11-16
NINGBO GREEN HEALTH PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the extraction methods of ginkgo leaves taken at home and abroad are generally ethanol extraction, evaporation concentration, filtration, resin adsorption, drying and other steps, but the yield of the product obtained by this method is low, and the quality is not stable

Method used

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  • Preparation method of ginkgo leaf extract
  • Preparation method of ginkgo leaf extract
  • Preparation method of ginkgo leaf extract

Examples

Experimental program
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Embodiment 1

[0031] Such as figure 1 Shown, the preparation method of the Ginkgo biloba extract described in this embodiment, its steps are as follows:

[0032] (1) Extraction step: 2 tons of ginkgo leaves are continuously dropped into the pulverizer to pulverize at a speed of 200kg / h-260kg / h, and are extracted with reverse gradient continuous extraction equipment. What the extraction solvent adopts is ethanol of 60% concentration, the flow rate of solvent 1.8M per hour 3 -2.0M 3 Put it into this equipment, the temperature is controlled at 40°C-70°C, and filter after the extraction is completed;

[0033] (2) Concentration step: Concentrate the filtrate through a thin film evaporator, control the flow rate at 2000L / h-3000L / h, and control the temperature at 60°C-90°C;

[0034] (3) centrifugation step: the concentrated solution is centrifuged by a centrifugal device with a separation factor above 3000;

[0035] (4) Extraction step: extract the concentrated solution after centrifugation wi...

Embodiment 2

[0040] The preparation method of the Ginkgo biloba extract described in this embodiment, its steps are as follows:

[0041] (1) Extraction step: 2 tons of ginkgo leaves are continuously dropped into pulverizer to pulverize at a speed of 200kg / h-260kg / h, and are extracted with reverse gradient continuous extraction equipment. What the extraction solvent adopts is acetone of 60% concentration, and the temperature is controlled at 40°C-70°C, filter after extraction;

[0042] (2) Concentration step: Concentrate the filtrate through a thin film evaporator, control the flow rate at 2000L / h-3000L / h, and control the temperature at 60°C-90°C;

[0043] (3) centrifugation step: the concentrated solution is centrifuged by a centrifugal device with a separation factor above 3000;

[0044] (4) Extraction step: extract the concentrated solution after centrifugation with acetone and butanone mixed solution, the mixing ratio of acetone and butanone is: acetone: butanone=1:1;

[0045] (5) Res...

Embodiment 3

[0049] The preparation method of the Ginkgo biloba extract described in this embodiment, its steps are as follows:

[0050] (1) Extraction step: 2 tons of ginkgo leaves are continuously dropped into the pulverizer to pulverize at a speed of 200kg / h-260kg / h, and are extracted with reverse gradient continuous extraction equipment. What the extraction solvent adopts is ethanol of 60% concentration, and the temperature is controlled at 40°C-70°C, filter after extraction;

[0051](2) Concentration step: Concentrate the filtrate through a thin film evaporator, control the flow rate at 2000-3000L / h, and control the temperature at 60°C-90°C;

[0052] (3) centrifugation step: the concentrated solution is centrifuged by a centrifugal device with a separation factor above 3000;

[0053] (4) Extraction step: extract the concentrated solution after centrifugation with a mixed solution of acetone and butanone, the mixing ratio of acetone and butanone is: acetone: butanone=1: 0.9;

[0054]...

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Abstract

The invention discloses a preparation method of a ginkgo leaf extract, characterized by comprising the following steps of: (1) extracting pulverized ginkgo leaves by a C1-C2 alcohol or C1-C4 ketone solvent and an adverse gradient continuous extraction device, and filtering, wherein 200kg-260kg of ginkgo leaves are fed per hour, and 1.8m<3>-2.0m<3> of solvent is fed into the device per hour; (2) concentrating the filtrate by a film evaporator; (3) centrifuging the concentrated liquid by a centrifugal device; (4) extracting the centrifuged concentrated liquid by one or more ketone solvents; (5)enabling the extract liquid to pass through macroporous resin, taking the effluent liquid part; (6) concentrating the effluent liquid by a film evaporator; and (7) enabling the concentrated liquid topass through a sterilizing filter and performing spray drying. The quality index of the ginkgo leaf extract obtained by the method disclosed by the invention meets the standard of European bulk drugs, the quality and grade of the product are better improved, and the method is easier to implement.

Description

technical field [0001] The invention belongs to the field of medicine preparation, and relates to a method for extracting and preparing medicinal materials, in particular to a method for preparing ginkgo leaf extract that meets the standards of European raw materials. Background technique [0002] Ginkgo biloba is a plant with high medicinal value, and Ginkgo biloba extract is a natural medicine with a wide range of effects and few adverse reactions. Its active ingredients are mainly ginkgo flavonoids and terpenoids, which have the functions of scavenging oxygen free radicals, antagonizing platelet activating factor (PAF), lowering blood fat, enhancing central nervous system function, regulating neurotransmitter and hormone levels, improving hemorheology, and anti-aging. Inflammatory, anti-allergic effects. [0003] In addition, according to modern clinical research, it has a significant effect on chronic schizophrenia with negative symptoms (such as social withdrawal, lazi...

Claims

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Application Information

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IPC IPC(8): A61K36/16A61P39/06A61P7/02A61P3/06A61P25/28A61P29/00A61P37/08A61P25/18A61K127/00
Inventor 卢国定
Owner NINGBO GREEN HEALTH PHARMACEUTICAL CO LTD
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