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Composition chewable tablet of zinc gluconate compound and its preparation method

A technology of zinc gluconate and composition, applied in the direction of drug combination, non-active ingredient medical preparations, medical preparations containing active ingredients, etc., can solve the problems of low absorption rate and achieve high absorption rate and small side effects Effect

Inactive Publication Date: 2011-12-07
广东好药多医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Composition chewable tablets of zinc gluconate compounds are more and more common because of their convenience in taking and carrying, and are especially suitable for patients such as the elderly and children, but their absorption rate in the human body is low, and they are often accompanied by nausea, vomiting, and abdominal pain and other side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The embodiment of the present invention a kind of preparation method of the composition chewable tablet of zinc gluconate compound, consists of the following steps:

[0028] (1) Weigh 35g of zinc gluconate, 1g of vitamin C, 4g of folic acid, 1.2g of xylitol, and

[0029] 2.8g pear alcohol, 9g maltodextrin, 13g malic acid, 25g orange essence, 8g aspartame, 1g magnesium stearate;

[0030] (2) Put the weighed xylitol and sorbitol into the mortar and mix evenly, pass through a 90-mesh sieve for later use;

[0031] (3) Add water to the weighed maltodextrin to prepare a solution A with a mass concentration of 5%;

[0032] (4) Mix the weighed zinc gluconate, vitamin C, folic acid, malic acid and orange flavor evenly, slowly add solution A, and keep stirring at the same time to make soft material B with moderate hardness;

[0033] (5) Use a 14-mesh sieve as a granulation tool, tightly hold the soft material B into a ball, and press it through a 14-mesh sieve to make the soft ...

Embodiment 2

[0037] The embodiment of the present invention a kind of preparation method of the composition chewable tablet of zinc gluconate compound, consists of the following steps:

[0038] (1) Weigh 38g of zinc gluconate, 2g of vitamin C, 6g of folic acid, 1.8g of xylitol, 3.6g of sorbitol, 20g of maltodextrin, 6g of malic acid, 16g of orange essence, 5g of aspartame, stearin Magnesium acid 1.6g;

[0039] (2) Put the weighed xylitol and sorbitol into the mortar and mix evenly, and pass through an 80-mesh sieve for later use;

[0040] (3) Add water to the weighed maltodextrin to prepare solution A with a mass concentration of 3%;

[0041] (4) Mix the weighed zinc gluconate, vitamin C, folic acid, malic acid and orange flavor evenly, slowly add solution A, and keep stirring at the same time to make soft material B with moderate hardness;

[0042] (5) Use a 15-mesh sieve as a granulation tool, tightly hold the soft material B into a ball, and press it through a 15-mesh sieve to make th...

Embodiment 3

[0046] The embodiment of the present invention a kind of preparation method of the composition chewable tablet of zinc gluconate compound, consists of the following steps:

[0047] (1) Weigh 40g of zinc gluconate, 3g of vitamin C, 1.5g of folic acid, 1g of xylitol, 4g of sorbitol, 6g of maltodextrin, 5g of malic acid, 30g of orange essence, 9g of aspartame, stearic acid Magnesium 0.5g;

[0048] (2) Put the weighed xylitol and sorbitol into the mortar and mix evenly, pass through a 100-mesh sieve for later use;

[0049] (3) Add water to the weighed maltodextrin to prepare a solution A with a mass concentration of 10%;

[0050] (4) Mix the weighed zinc gluconate, vitamin C, folic acid, malic acid and orange flavor evenly, slowly add solution A, and keep stirring at the same time to make soft material B with moderate hardness;

[0051] (5) Use a 12-mesh sieve as a granulation tool, tightly hold the soft material B into a ball, and press it through a 12-mesh sieve to make the so...

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Abstract

The invention discloses composition chewing tablets for a zinc gluconate compound. The composition chewing tablets are prepared from the following components in percentage by mass: 30 to 40 percent of zinc gluconate, 0.5 to 3 percent of vitamin C, 1.5 to 9 percent of folic acid, 1 to 2 percent of xylitol, 2.5 to 4 percent of sorbierite, 6 to 25 percent of maltose dextrin, 5 to 15 percent of malicacid, 10 to 30 percent of orange essence, 2 to 10 percent of aspartame and 0.5 to 2 percent of magnesium stearate. The composition chewing tablets for the zinc gluconate compound are high in adsorption rate and the probability of side effects of nausea, vomit, abdominal pain and the like after administration of the tablets is small. The invention also provides a preparation method for the composition chewing tablets for the zinc gluconate compound.

Description

technical field [0001] The invention relates to a formulation of a zinc gluconate compound composition chewable tablet and a preparation method thereof. Background technique [0002] Zinc is one of the essential trace elements for the human body. When the human body intakes insufficiently and the demand increases, nutritional zinc deficiency disease will appear. If children and teenagers are deficient in zinc, they will suffer from anorexia, partial eclipse, oral ulcers, poor growth, decreased immunity, and even dwarfism and mental retardation. [0003] Zinc gluconate, as a zinc supplement, is mainly used for growth retardation, malnutrition, anorexia and other symptoms caused by zinc deficiency in infants, the elderly and pregnant women. The commonly used zinc gluconate oral liquid, zinc gluconate granules and glucose Zinc acid chewable tablets. Composition chewable tablets of zinc gluconate compounds are more and more common because of their convenience in taking and car...

Claims

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Application Information

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IPC IPC(8): A61P3/02A61K31/191A61K9/20A61K47/22A61K47/36
Inventor 吴秋萍
Owner 广东好药多医药有限公司
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