Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of non-steroidal anti-inflammatory tablet and preparation method thereof

A non-steroidal anti-inflammatory drug, non-steroidal anti-inflammatory technology, applied in the direction of anti-inflammatory agents, antipyretics, drug combinations, etc., can solve the problems of low temperature fusion, increased gastrointestinal stimulation, tablet sticking and punching, etc. , to achieve the effect of improving stability, superior performance, and improving dissolution and release

Inactive Publication Date: 2011-12-07
蚌埠丰原涂山制药有限公司
View PDF6 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is often used in the form of tablets, but because aspirin is unstable when exposed to heat and humidity, it is easy to degrade into free salicylic acid and increase the irritation to the gastrointestinal tract. At present, domestic manufacturers mostly use tartaric acid to slow down the degradation of aspirin
In addition, due to the low melting point of aspirin, it is easy to cause low-temperature co-melting with other materials, resulting in the common aspirin tablet sticking.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of non-steroidal anti-inflammatory tablet and preparation method thereof
  • A kind of non-steroidal anti-inflammatory tablet and preparation method thereof
  • A kind of non-steroidal anti-inflammatory tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] 1. Raw material and formula

[0011] Aspirin 0.3g

[0012] Pregelatinized starch 0.06g

[0013] Anhydrous citric acid 0.01g

[0014] Hydroxypropyl cellulose 0.03g

[0015] 8% starch slurry 0.001g

[0016] Talc powder 0.004g

[0017] 2. Preparation method

[0018] Consists of the following steps:

[0019] (1) Pulverize each raw and auxiliary material, pass through a 80-100 mesh sieve, and weigh for subsequent use;

[0020] (2) Mix aspirin, pregelatinized starch, anhydrous citric acid, and hydroxypropyl cellulose evenly;

[0021] (3) make soft material with 8% starch slurry, granulate, dry;

[0022] (4) Add talcum powder, mix and press into tablets.

Embodiment 2

[0024] 1. Raw material and formula

[0025] Aspirin 0.3g

[0026] Pregelatinized starch 0.06g

[0027] Anhydrous citric acid 0.01g

[0028] Hydroxypropyl cellulose 0.03g

[0029] 5% hypromellose 0.001g

[0030] Talc powder 0.004g

[0031] 2. Preparation method

[0032] Consists of the following steps:

[0033] (1) Pulverize each raw and auxiliary material, pass through a 80-100 mesh sieve, and weigh for subsequent use;

[0034] (2) Mix aspirin, pregelatinized starch, anhydrous citric acid, and hydroxypropyl cellulose evenly;

[0035] (3) make soft material with 5% hypromellose, granulate, dry;

[0036] (4) Add talcum powder, mix and press into tablets.

Embodiment 3

[0038] 1. Raw material and formula

[0039] Aspirin 0.3g

[0040] Pregelatinized starch 0.06g

[0041] Anhydrous citric acid 0.01g

[0042] Hydroxypropyl cellulose 0.03g

[0043] 8% polyvinylpyrrolidone 0.001g

[0044] Micropowder silica gel 0.004g

[0045] 2. Preparation method

[0046] Consists of the following steps:

[0047] (1) Pulverize each raw and auxiliary material, pass through a 80-100 mesh sieve, and weigh for subsequent use;

[0048] (2) Mix aspirin, pregelatinized starch, anhydrous citric acid, and hydroxypropyl cellulose evenly;

[0049] (3) make soft material with 8% polyvinylpyrrolidone, granulate and dry;

[0050] (4) Add micropowder silica gel to mix and press into tablets.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a non-steroidal anti-inflammatory tablet and a preparation method thereof. The tablet is composed of a main drug non-steroidal anti-inflammatory drug, a filler pregelatinized starch, a complexing agent anhydrous citric acid, and a disintegrating agent hydroxypropyl The non-steroidal anti-inflammatory drug is aspirin, ibuprofen or paracetamol, and the weight percentage of the non-steroidal anti-inflammatory drug in the tablet is 12.5-75%. The tablets made from the above raw materials have a smooth and beautiful surface and high hardness, which effectively solves the problems of sticking and punching during the tableting process, and the tablet is easily broken and edged during the coating process. It has good disintegration performance and fast release speed. In addition, adding anhydrous citric acid to the tablet can complex metal ions, thereby reducing the formation of free salicylic acid, improving the stability of non-steroidal anti-inflammatory drugs, and it is also an ideal coating tablet core for non-steroidal anti-inflammatory drugs .

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a non-steroidal anti-inflammatory tablet and a preparation method thereof. Background technique [0002] Aspirin is a non-steroidal anti-inflammatory drug, which can inhibit cyclooxygenase, reduce the synthesis of prostaglandins, and has antipyretic, analgesic, and anti-inflammatory effects. It is often used clinically in the form of tablets, but because aspirin is unstable when exposed to heat and humidity, it is easily degraded into free salicylic acid and increases the irritation to the gastrointestinal tract. At present, domestic manufacturers mostly use tartaric acid to slow down the degradation of aspirin. In addition, due to the low melting point of aspirin, it is easy to cause low-temperature co-melting with other materials, resulting in the general sticking of aspirin tablets. Contents of the invention [0003] The object of the present invention is to provide a no...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/38A61P29/00
Inventor 李保琴侯飞
Owner 蚌埠丰原涂山制药有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com