A kind of compound analgesic composition and preparation method thereof

Abstract

The present invention relates to a compound analgesic composition for combination of symptomatic treatment and causal treatment, comprising analgesics with a weight ratio of 5∽200, and 0.1∽5000 weight ratio of other analgesics acting on the circulatory system, Drugs and excipients for one or more systems in the motor system and nervous system. The invention has the characteristics of good effect, emphasizing both symptomatic and causal treatment, and treating both symptoms and root causes, and is also a discussion on the combination of traditional and modern medicine.

Description

technical field [0001] The invention relates to a compound analgesic composition for combination of symptomatic treatment and causative treatment, which acts on one or more systems in circulatory system, motor system and nervous system, and also relates to its preparation method. Background technique [0002] Pain is caused by a variety of reasons, such as sterile inflammation, nerve injury, trauma, dysmenorrhea, and even postoperative adhesions, involving multiple systems and tissues, such as nerves, bones, and organs. Symptoms include anxiety, insomnia, and numbness , skeletal muscle or smooth muscle spasm, modern medicine isolates the symptom and the cause in the treatment of drugs. For example, the American Geriatrics Association recommends acetaminophen to treat senile pain, without taking into account osteoporosis, osteoarthritis, and anxiety Etc. etiology; most of the compound drugs in the past were mainly for analgesia, such as compound aspirin, and although compound...

AI Technical Summary

Problems solved by technology

[0002] Pain is caused by a variety of reasons, such as sterile inflammation, nerve injury, trauma, dysmenorrhea, and even postoperative adhesions, involving multiple systems and tissues, such as nerves, bones, and organs. Symptoms include anxiety, insomnia, and numbness , skeletal muscle or smooth muscle spasm, modern medicine isolates the symptom and the cause in the treatment of drugs. For example, the American Geriatrics Association recommends acetaminophen to treat senile pain, without taking into account osteoporosis, osteoarthritis, and anxiety Etc. etiology; most of the compound drugs in the past were mainly for analgesia, such as compound aspirin, and although compound chlorzoxazone has analgesic and muscle relaxant effects, it has no anti-inflammatory and neurotrophic effects, and has poor effects on moderate pain and smooth muscle pain. There is no treatment for accompanying symptoms such as anxiety and numbness; the anti-inflammatory effects of aminopyrine and phenacetin in Qutong Tablets are weak, and the combined effect of the two non-steroidal drugs does not increase, and the side effects will increase. Although it has sedative, hypnotic and anticonvulsant effects, it has slow absorption, long half-life of 24 to 96 hours, high concentration in brain tissue, and poor safety; in addition, the composition of 95194879.2 is relatively single, and there is no prominent multi-directional combination method; It involves pain relief treatment; 200510010899.6 only uses Chinese herbal medicines as raw materials, without chemical drugs; 200510012938.6 has a narrow range of treatment and does not involve multiple combination methods; 200510090679.9 does not solve the problem of combination of Chinese and Western medicines in terms of combination methods although Chinese and Western medicines are used together; 200610019249.2 is aimed at migraine Effective, but the treatment range is narrow; 201010200639.6 has anti-inflammatory and analgesic effects, but the combination method is single; 200810172016.5 can both structure and method of pain relief, but the combination method is single; 200610092010.8 involves the combination of Chinese and Western, but does not clarify the drug conditions from the perspective of pharmacology and rational combination of compounds and principle; 200610092010. 8 Although the analgesics of the combination of traditional Chinese and Western medicine are given, the chemical drugs are limited to luminal and ibuprofen, and the traditional Chinese medicine formula is complicated, and the content of active ingredients is not easy to control; part 02811420.5 mentions the side effects of related drugs and the etiology and complications of pain, but only provides two pain relief structures, and fails to systematically treat symptoms and causes, and does not mention the prevention and treatment of adverse reactions and drug combinations; some people think that pain is a manifestation of anxiety , did not realize that pain can bring anxiety and irritability, painkillers and anti-anxiety drugs and only anti-anxiety treatment, did not use drugs from the accompanying symptoms of pain, and the drugs were limited; glucosamine can partially counteract the part of non-steroidal drugs Side effects may block the pathological process of osteoarthritis. The combination of the two complements each other, but there are still gastrointestinal reactions, so it is more exciting to add traditional Chinese medicine to protect the gastrointestinal tract; Kailai, a single treatment, used to take painkillers as first-line drugs, antidepressants, anticonvulsants, muscle relaxants, etc. as second-line drugs, without treating the human body as a unified whole, systematized and comprehensive Treatment cannot treat both symptoms and root causes, resulting in incomplete analgesia and many side effects. At the same time, insufficient attention is paid to the side effects of drugs. There is no relevant research on this type of drugs with "harmonious drugs", which often leads to side effects during treatment. new disease