A kind of compound analgesic composition and preparation method thereof

A composition and compound technology, applied in the field of compound analgesic compositions, can solve the problems of no pain relief treatment, no treatment, high brain tissue concentration, etc.

Inactive Publication Date: 2011-12-07
赵磊
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Pain is caused by a variety of reasons, such as sterile inflammation, nerve injury, trauma, dysmenorrhea, and even postoperative adhesions, involving multiple systems and tissues, such as nerves, bones, and organs. Symptoms include anxiety, insomnia, and numbness , skeletal muscle or smooth muscle spasm, modern medicine isolates the symptom and the cause in the treatment of drugs. For example, the American Geriatrics Association recommends acetaminophen to treat senile pain, without taking into account osteoporosis, osteoarthritis, and anxiety Etc. etiology; most of the compound drugs in the past were mainly for analgesia, such as compound aspirin, and although compound chlorzoxazone has analgesic and muscle relaxant effects, it has no anti-inflammatory and neurotrophic effects, and has poor effects on moderate pain and smooth muscle pain. There is no treatment for accompanying symptoms such as anxiety and numbness; the anti-inflammatory effects of aminopyrine and phenacetin in Qutong Tablets are weak, and the combined effect of the two non-steroidal drugs does not increase, and the side effects will increase. Although it has sedative, hypnotic and anticonvulsant effects, it has slow absorption, long half-life of 24 to 96 hours, high concentration in brain tissue, and poor safety; in addition, the composition of 95194879.2 is relatively single, and there is no prominent multi-directional combination method; It involves pain relief treatment; 200510010899.6 only uses Chinese herbal medicines as raw materials, without chemical drugs; 200510012938.6 has a narrow range of treatment and does not involve multiple combination methods; 200510090679.9 does not solve the problem of combination of Chinese and Western medicines in terms of combination methods although Chinese and Western medicines are used together; 200610019249.2 is aimed at migraine Effective, but the treatment range is narrow; 201010200639.6 has anti-inflammatory and analgesic effects, but the combination method is single; 200810172016.5 can

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] The drug weight ratio is 10-50 for diclofenac, 0.5-5 for diazepam, 10-100 for caffeine, 100-5000 for Panax notoginseng or its extract, or 100-5000 for licorice or its extract, or 100-5000 for licorice or its extract, or 100-5000 for diazepam or its extract Extract or tetrahydropalmatine 10~500, excipients 10~5000. It is mainly used to treat a variety of common pains, such as pain caused by sports injuries, degenerative diseases, arthralgia, osteoarthritis, rheumatism and pain caused by rheumatoid diseases.

[0076]

[0077] Recipe 1 Ingredient Weight (grams)

[0078] Diclofenac potassium (sodium) 100~500

[0079] Diazepam 10~50

[0080] Caffeine 100~1000

[0081] Panax notoginseng extract (or tetrahydropalmatine or licorice extract) 100~5000

[0082]Sodium croscarmellose 10~50

[0083] Povidone (K30) 2~20

[0084] Magnesium stearate 1~10

[0085] Microcrystalline cellulose 10~500

[0086] Make 10,000 pieces according to methods known in the art

[0087] Prefer...

Embodiment 2

[0124] The drug weight ratio is 10-50 for diclofenac, 0.5-5 for diazepam, 10-1000 for caffeine and 10-5000 for auxiliary materials. It is mainly used to treat a variety of common pains, such as pain caused by sports injuries, degenerative diseases, arthralgia, osteoarthritis, rheumatism and pain caused by rheumatoid diseases.

[0125] Recipe Ingredient Weight (grams)

[0126] Diclofenac potassium (sodium) 100--500

[0127] Diazepam 5--50

[0128] Caffeine 100--10000

[0129] Calcium hydrogen phosphate 100--5000

[0130] Croscarmellose sodium 10--100

[0131] Povidone (K30) 2--100

[0132] Magnesium stearate 1--100

[0133] Microcrystalline cellulose 10--1000

[0134] Make 10,000 pieces according to methods known in the art

[0135] preferred solution

[0136] Recipe Ingredient Weight (grams)

[0137] Diclofenac potassium (sodium) 250

[0138] Diazepam 25

[0139] Caffeine 250

[0140] Calcium hydrogen phosphate 1334

[0141] Croscarmellose Sodium 30

[0142] Pov...

Embodiment 3

[0147] The drug weight ratio is 10-50 for diclofenac, 5-50 for nefopam or 20-200 for tramadol, 1-50 for clomipramine or 5-50 for fluoxetine or 5-50 for paroxetine, and 10-50 for auxiliary materials. 5000. It is mainly used to treat a variety of common pains, such as pain caused by sports injuries, degenerative diseases, arthralgia, osteoarthritis, rheumatism and pain caused by rheumatoid diseases.

[0148]

[0149] preferred solution

[0150] Recipe Ingredient Weight (grams)

[0151] Diclofenac potassium (sodium) 250

[0152] Nefopam 25

[0153] Clomipramine 25

[0154] Calcium hydrogen phosphate 1559

[0155] Croscarmellose Sodium 30

[0156] Povidone (K30) 8

[0157] Magnesium stearate 3

[0158] Microcrystalline Cellulose 100

[0159] Make 10,000 pieces according to methods known in the art

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PUM

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Abstract

The present invention relates to a compound analgesic composition for combination of symptomatic treatment and causal treatment, comprising analgesics with a weight ratio of 5∽200, and 0.1∽5000 weight ratio of other analgesics acting on the circulatory system, Drugs and excipients for one or more systems in the motor system and nervous system. The invention has the characteristics of good effect, emphasizing both symptomatic and causal treatment, and treating both symptoms and root causes, and is also a discussion on the combination of traditional and modern medicine.

Description

technical field [0001] The invention relates to a compound analgesic composition for combination of symptomatic treatment and causative treatment, which acts on one or more systems in circulatory system, motor system and nervous system, and also relates to its preparation method. Background technique [0002] Pain is caused by a variety of reasons, such as sterile inflammation, nerve injury, trauma, dysmenorrhea, and even postoperative adhesions, involving multiple systems and tissues, such as nerves, bones, and organs. Symptoms include anxiety, insomnia, and numbness , skeletal muscle or smooth muscle spasm, modern medicine isolates the symptom and the cause in the treatment of drugs. For example, the American Geriatrics Association recommends acetaminophen to treat senile pain, without taking into account osteoporosis, osteoarthritis, and anxiety Etc. etiology; most of the compound drugs in the past were mainly for analgesia, such as compound aspirin, and although compound...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61P29/00A61P25/04
Inventor 赵磊
Owner 赵磊
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