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Bezoar and musk containing pharmaceutical composition and its application

A technology of medicine, bezoar, which is applied in the field of pharmaceutical composition, can solve the problems such as lack of positive effect and achieve significant curative effect

Inactive Publication Date: 2012-11-07
秦引林
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A new drug active ingredient is added to the active system of the original drug. Although it is the same ingredient, if it does not work together in the drug combination, it may not have a positive effect.

Method used

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  • Bezoar and musk containing pharmaceutical composition and its application
  • Bezoar and musk containing pharmaceutical composition and its application
  • Bezoar and musk containing pharmaceutical composition and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1. Therapeutic effect on rat cerebral ischemia-reperfusion injury

[0032] a. Material

[0033] Pharmaceutical composition A of the present invention (bezoar + musk + sodium tanshinone IIA sulfonate 3:2:5, 5, 10, 20 mg / kg injection)

[0034] Pharmaceutical composition B of the present invention (bezoar + musk + ginkgolide 3:1:6, 5, 10, 20 mg / kg injection)

[0035] Blank control group: normal saline

[0036] Positive control group: Niuhuang Injection, Muscone Injection, Ginkgolide Injection 5mg / kg, Tanshinone IIA Sodium Sulfonate Injection 5mg / kg

[0037] b. Method

[0038]96 clean-grade male SD rats, weighing 250-300g, were used to prepare the rat middle cerebral artery occlusion (MCAO) model by using the internal carotid artery suture method: separate the rat internal carotid artery, and loosen the root of the external carotid artery with silk thread Clamp the common carotid artery and the internal carotid artery. The fishing line (length 40mm, diameter 0....

Embodiment 2

[0053] Example 2. Effects on Mice's Resistance to Cerebral Ischemia and Hypoxia

[0054] a. Material

[0055] Pharmaceutical composition A of the present invention (bezoar + musk + notoginseng saponin 3:2:5, 10, 20, 40mg / kg gavage)

[0056] The pharmaceutical composition B of the present invention (bezoar + musk + ligustrazine 2: 1: 7, 10, 20, 40mg / kg gavage)

[0057] Blank control group: normal saline

[0058] Positive control group: bezoar, musk, notoginsenoside 20mg / kg, ligustrazine 20mg / kg

[0059] b. method

[0060] In the acute cerebral ischemic hypoxia experiment, 110 mice were randomly divided into 11 groups, which were the ischemic model control group, positive control group, high (40mg / kg), medium (20mg / kg), and low dose of the test drug. group (10mg / kg), 10 rats in each group. The mice in each group were gavaged continuously for 10 days, and 1 hour after the last gavage, the mice in each group were intraperitoneally injected with NaNO2 solution (mass concentrat...

Embodiment 3

[0067] Example 3. Anticoagulation induced thrombosis

[0068] a.Material

[0069] Pharmaceutical composition A of the present invention (bezoar + musk + safflower yellow 3:1:6, 5, 10, 20 mg / kg injection)

[0070] Pharmaceutical composition B of the present invention (bezoar + musk + ginkgolide 5:2:3, 5, 10, 20 mg / kg injection)

[0071] Blank control: normal saline

[0072] Positive control: bezoar, musk, safflower yellow 10mg / kg, ginkgolide 10mg / kg

[0073] b. method

[0074] Rats were injected with drug combinations A and B once a day for 3 consecutive days through the tail vein, and 1 hour after the last injection, the rats were anesthetized by intraperitoneal injection of 12% chloral hydrate 350 mg / kg, and fixed in a supine position. A midline incision was made in the neck, and the left common carotid artery was freed. The stimulating electrode of the BT87-3 experimental in vivo thrombosis measuring instrument was placed at the proximal end, and the temperature probe wa...

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Abstract

The invention relates to a pharmaceutical composition which is developed on the basis of the modern medicine theory and contains bezoar, musk and natural plant extracts or monomers. The composition has good functions of preventing and treating cerebrovascular diseases. Based on the drug combination of bezoar and musk, a plurality of plant drug combinations are added. The pharmaceutical composition has a more substantial curative effect of treating cerebrovascular diseases (including cerebral thrombus, cerebral ischemia, cerebral infarction, traumatic brain injury and the like) than original medicines.

Description

technical field [0001] The invention relates to a pharmaceutical composition, which is a pharmaceutical composition containing bezoar, musk and natural plant extracts or monomers developed according to modern pharmaceutical theory and its application in preventing and treating cerebrovascular diseases. technical background [0002] Bezoar and musk are two traditional Chinese medicines derived from animals, which have been widely used in the clinical treatment of cardiovascular and cerebrovascular diseases in modern medicine. [0003] Chinese medicine believes that Calculus Calculus can be used for antipyretic, detoxification and calming convulsions. Oral administration to treat high fever, coma, mania, infantile convulsions, convulsions and other diseases. External use is used to control sore throat, aphthous carbuncle, and toxin. Modern medical research has found that it has a wide range of effects in the protection of the central nervous system, the treatment of cerebral...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16A61K36/236A61K36/258A61K36/286A61K36/537A61K36/71A61P9/00A61K31/5685A61K31/575A61K35/413A61K35/55
Inventor 秦引林
Owner 秦引林
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