Bezoar and musk containing pharmaceutical composition and its application
A technology of medicine, bezoar, which is applied in the field of pharmaceutical composition, can solve the problems such as lack of positive effect and achieve significant curative effect
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0031] Example 1. Therapeutic effect on rat cerebral ischemia-reperfusion injury
[0032] a. Material
[0033] Pharmaceutical composition A of the present invention (bezoar + musk + sodium tanshinone IIA sulfonate 3:2:5, 5, 10, 20 mg / kg injection)
[0034] Pharmaceutical composition B of the present invention (bezoar + musk + ginkgolide 3:1:6, 5, 10, 20 mg / kg injection)
[0035] Blank control group: normal saline
[0036] Positive control group: Niuhuang Injection, Muscone Injection, Ginkgolide Injection 5mg / kg, Tanshinone IIA Sodium Sulfonate Injection 5mg / kg
[0037] b. Method
[0038]96 clean-grade male SD rats, weighing 250-300g, were used to prepare the rat middle cerebral artery occlusion (MCAO) model by using the internal carotid artery suture method: separate the rat internal carotid artery, and loosen the root of the external carotid artery with silk thread Clamp the common carotid artery and the internal carotid artery. The fishing line (length 40mm, diameter 0....
Embodiment 2
[0053] Example 2. Effects on Mice's Resistance to Cerebral Ischemia and Hypoxia
[0054] a. Material
[0055] Pharmaceutical composition A of the present invention (bezoar + musk + notoginseng saponin 3:2:5, 10, 20, 40mg / kg gavage)
[0056] The pharmaceutical composition B of the present invention (bezoar + musk + ligustrazine 2: 1: 7, 10, 20, 40mg / kg gavage)
[0057] Blank control group: normal saline
[0058] Positive control group: bezoar, musk, notoginsenoside 20mg / kg, ligustrazine 20mg / kg
[0059] b. method
[0060] In the acute cerebral ischemic hypoxia experiment, 110 mice were randomly divided into 11 groups, which were the ischemic model control group, positive control group, high (40mg / kg), medium (20mg / kg), and low dose of the test drug. group (10mg / kg), 10 rats in each group. The mice in each group were gavaged continuously for 10 days, and 1 hour after the last gavage, the mice in each group were intraperitoneally injected with NaNO2 solution (mass concentrat...
Embodiment 3
[0067] Example 3. Anticoagulation induced thrombosis
[0068] a.Material
[0069] Pharmaceutical composition A of the present invention (bezoar + musk + safflower yellow 3:1:6, 5, 10, 20 mg / kg injection)
[0070] Pharmaceutical composition B of the present invention (bezoar + musk + ginkgolide 5:2:3, 5, 10, 20 mg / kg injection)
[0071] Blank control: normal saline
[0072] Positive control: bezoar, musk, safflower yellow 10mg / kg, ginkgolide 10mg / kg
[0073] b. method
[0074] Rats were injected with drug combinations A and B once a day for 3 consecutive days through the tail vein, and 1 hour after the last injection, the rats were anesthetized by intraperitoneal injection of 12% chloral hydrate 350 mg / kg, and fixed in a supine position. A midline incision was made in the neck, and the left common carotid artery was freed. The stimulating electrode of the BT87-3 experimental in vivo thrombosis measuring instrument was placed at the proximal end, and the temperature probe wa...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com