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Coronary artery stent with anticoagulant effect and preparation method thereof

A coronary and anticoagulant technology, applied in anticoagulation treatment, packaging item types, special packaging items, etc., can solve problems such as easily damaged coatings, reduce protein adsorption, inhibit denaturation, inhibit cell adsorption and inflammation effect of reaction

Inactive Publication Date: 2011-12-14
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the commonly used method is to use high temperature or disinfectant for disinfection and sterilization, but these methods are easy to damage the coating

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] 1. Take the stainless steel bracket and use acetone, deionized water, and methanol to ultrasonically treat it, take it out, dry it, load it into a centrifuge device, and put it into a centrifuge tube.

[0029] 2. Take 1 mg of hyperbranched star-shaped amphiphilic SPLA-b-PMPC polymer nanoparticles and dissolve them in 100 ml of methanol to prepare a coating solution.

[0030] 3. Add the coating solution into the centrifuge tube with the stainless steel bracket until the coating solution completely submerges the bracket. The stent rolls slowly with the centrifugal device, and the whole stent is in full contact with the coating liquid, and the whole process is subject to the fact that no air bubbles are generated. After 5 minutes of rotation, the stent was slowly withdrawn from the coating solution.

[0031] 4. Place the rack on the centrifuge device again, load it into a centrifuge tube, and centrifuge at a speed of 1000-7000 rpm for 1 minute.

[0032] 5. After centrifu...

Embodiment 2

[0036] 1. Take the nickel-titanium alloy bracket and use acetone, deionized water, and methanol to ultrasonically treat it, take it out, dry it, load it into a centrifuge device, and load it into a centrifuge tube.

[0037] 2. Take 1000 mg of hyperbranched star-shaped amphiphilic SPLA-b-PMPC polymer nanoparticles and dissolve them in 100 ml of ethanol to prepare a coating solution.

[0038] 3. Add the coating solution into the centrifuge tube with the Nitinol stent until the coating solution completely submerges the stent. The stent rolls slowly with the centrifugal device, and the whole stent is in full contact with the coating liquid, and the whole process is subject to the fact that no air bubbles are generated. After spinning for 20 minutes, slowly withdraw the stent from the coating solution.

[0039] 4. Place the rack on the centrifuge device again, load it into a centrifuge tube, and centrifuge at a speed of 10,000-15,000 rpm for 10 minutes.

[0040] 5. After centrifu...

Embodiment 3

[0044] 1. Take the cobalt-chromium alloy stent and ultrasonically treat it with acetone, deionized water, and methanol, take it out, dry it, load it into a centrifuge device, and load it into a centrifuge tube.

[0045] 2. Take 100 mg of hyperbranched star-shaped amphiphilic SPLA-b-PMPC polymer nanoparticles and dissolve them in 100 ml of acetone to prepare a coating solution.

[0046] 3. Add the coating solution into the centrifuge tube with the cobalt-chromium alloy stent until the coating solution completely submerges the stent. The stent rolls slowly with the centrifugal device, and the whole stent is in full contact with the coating liquid, and the whole process is subject to the fact that no air bubbles are generated. After spinning for 10 minutes, slowly withdraw the stent from the coating solution.

[0047] 4. Place the rack on the centrifuge device again, load it into a centrifuge tube, and centrifuge at a speed of 7000-10000 rpm for 5 minutes.

[0048] 5. After cen...

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PUM

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Abstract

The invention discloses a coronary artery stent with anticoagulant effect and a preparation method thereof. The hyperbranched star-shaped amphiphilic SPLA-b-PMPC polymer nano particle coating is arranged on the support. Dissolve the treated stent in an organic solvent of hyperbranched star-shaped amphiphilic SPLA-b-PMPC polymer nanoparticles to prepare a coating solution; then take out the stent; place the stent on a centrifuge device and load it into a centrifuge tube , centrifuged, and dried under reduced pressure at room temperature to complete the coating. The 2-methacryloyloxyethylphosphorylcholine contained in the coating liquid of this coronary artery stent has little interaction with blood components, which can effectively inhibit blood coagulation and complement activation, and reduce protein adsorption , Inhibit the denaturation of adsorbed protein and platelet adhesion, can inhibit cell adsorption and inflammatory response, has good blood and tissue compatibility, and has a good anticoagulant effect, and has good application in cardiovascular and cerebrovascular diseases prospect.

Description

technical field [0001] The invention discloses a coronary artery stent with anticoagulant effect and a preparation method thereof. Background technique [0002] Coronary artery stents have developed rapidly since they were used clinically, and have been used more and more. At present, they have become the main means of myocardial revascularization. In the cardiac cath labs of many hospitals, coronary stents are implanted in 80% of cases during percutaneous coronary intervention. The reasons are: (1) The angiographic image after implantation of the stent is very good, and the results in the acute phase are good; (2) Since the stent can treat acute or near occlusion caused by balloon expansion, the safety of interventional therapy is significantly improved; (3) ) stents can reduce the rate of restenosis and improve the long-term prognosis of patients; (4) the implantation of stents is easy to operate; (5) the application of stents can reduce the operation time; (6) for comple...

Claims

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Application Information

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IPC IPC(8): A61L33/06A61L31/10
Inventor 亓洪昭马桂秋何立刚盛京原续波
Owner TIANJIN UNIV
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