Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Photopolymerizable chitosan derivative as well as preparation method and application thereof

A chitosan derivative, photopolymerization technology, applied in the field of biopolymer materials, can solve the problems of difficult control of reaction conditions, complicated post-processing, long gel time, etc., and achieves environmental protection, good biocompatibility, simple steps

Active Publication Date: 2013-04-24
BEIJING UNIV OF CHEM TECH
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there is following shortcoming in the method for above-mentioned preparation hydrogel: 1, reaction condition is difficult to control
2. Toxic substances are introduced during the preparation process, the post-processing is complicated, and the cost is increased
3. The gel time is longer and the degradation is slow

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Photopolymerizable chitosan derivative as well as preparation method and application thereof
  • Photopolymerizable chitosan derivative as well as preparation method and application thereof
  • Photopolymerizable chitosan derivative as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Add chitosan (deacetylation degree DD=70%, weight average molecular weight Mw=50,000) into 2wt% acetic acid solution, stir at room temperature for 0.5h, and prepare 1% by weight chitosan solution. Adding methacryloylglycine, EDC and NHS added to 15mL deionized water with an amount of 2 times the amino molar number on the chitosan, the mol ratio of methacryloylglycine, EDC, NHS is 1: 2: 2, The carboxyl group was activated by magnetic stirring for 2 h. It was slowly added dropwise to the acetic acid solution of chitosan, and reacted at room temperature for 6h. Adjust the pH value to 8 with 1mol / L NaOH solution, dialyze with deionized water, and freeze-dry to obtain photopolymerizable chitosan derivatives. The product structure is as follows:

[0039]

[0040] Wherein, n=0.7, m=0.3, 0

[0041] Figure 1A with 1B The IR spectrum and H NMR spectrum of the product methacryloylglycyl chitosan are given respectively.

[0042] The prepared photopolymerizable chito...

Embodiment 2

[0044] Add chitosan (deacetylation degree DD=90%, weight average molecular weight Mw=100,000) into 2wt% acetic acid solution, stir at room temperature for 1 hour, and prepare chitosan solution with a weight percentage of 1%. Adding methacryloylglycine, EDC and NHS added to 15mL deionized water with an amount of 2 times the molar amino group on the chitosan, the mol ratio of methacryloylglycine, EDC, NHS is 1: 4: 4, The carboxyl group was activated by magnetic stirring for 2 h. It was slowly added dropwise to the acetic acid solution of chitosan, and reacted at room temperature for 8h. Adjust the pH value to 8 with 1mol / L NaOH solution, dialyze with deionized water, and freeze-dry to obtain photopolymerizable chitosan derivatives. The product structure is as follows:

[0045]

[0046] Wherein, n=0.9, m=0.1, 0

[0047] The prepared photopolymerizable chitosan derivative is dissolved in 2wt% acetic acid solution to form a solution of 85% by weight, adding 1% of photopo...

Embodiment 3

[0049] Add chitosan (deacetylation degree DD=80%, weight average molecular weight Mw=50,000) into 2wt% acetic acid solution, stir at room temperature for 2h, and prepare 2wt% chitosan solution. Adding methacryloylglycine, EDC and NHS added to 15 mL of deionized water with an amount of 1 times the molar amino group on chitosan, the mol ratio of methacryloylglycine, EDC, NHS is 3: 2: 2, The carboxyl group was activated by magnetic stirring for 3 h. It was slowly added dropwise to the acetic acid solution of chitosan, and reacted at room temperature for 8h. Adjust the pH value to 8 with 1mol / L NaOH solution, dialyze with deionized water, and freeze-dry to obtain photopolymerizable chitosan derivatives. The product structure is as follows:

[0050]

[0051] Wherein, n=0.8, m=0.2, 0

[0052] The prepared photopolymerizable chitosan derivative is dissolved in 2wt% acetic acid solution to form a solution of 80% by weight, and 2% of the photopolymerizable chitosan derivat...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a photopolymerizable chitosan derivative. The derivative is prepared by adding an activated mixed solution of methacrylamide carboxylic acid or acrylamide carboxylic acid, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS) into an acetic acid solution of chitosan dropwise, reacting at room temperature, regulating the pH value to 8, dialyzing with deionized water and lyophilizing. The derivative remains the original bioactivity and biocompatibility of chitosan, and introduces a new photopolymerizable group, can be polymerized through initiation of an initiator 2959 under ultraviolet radiation, and has the advantages of mild reaction condition, simple steps, easiness for control and environmentally-friendly post-treatment; and the prepared hydrogel has the advantages of low toxicity and excellent biocompatibility.

Description

technical field [0001] The invention relates to a biopolymer material, in particular to a photopolymerizable chitosan derivative; the invention also relates to a preparation method of the derivative and its application in hydrogel preparation. Background technique [0002] Chitin widely exists in the shells of insects, marine invertebrates, and fungal cells. It is the second largest natural biopolymer in nature after cellulose. Chitosan is a deacetylated derivative of chitin. The only natural active polysaccharide with cations in nature, has good biocompatibility, biodegradability, non-toxic antibacterial and non-immunogenicity, etc. It is widely used in cosmetics, tissue printing and dyeing, agriculture, food industry, tissue engineering, burns, etc. It is widely used in dressings and drug carriers. [0003] There are hydroxyl groups and amino groups in the molecular structure of chitosan, which can form intramolecular and intermolecular hydrogen bonds, making chitosan ins...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C08B37/08C08J3/24C08J3/075C08F122/38C08F2/48
Inventor 马贵平聂俊徐娟朱晓群
Owner BEIJING UNIV OF CHEM TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com