A kind of azithromycin gel eye drop and its preparation process
Azithromycin and its preparation technology are applied in medical preparations containing non-active ingredients, medical preparations containing active ingredients, organic active ingredients, etc., and can solve the problems of low bioavailability, short residence time, and poor drug absorption, etc. , to achieve the effects of reducing drug loss, increasing residence time, and delaying drug release
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0032] Example 1: Weigh 0.15 g of azithromycin and dissolve it with an appropriate amount of citric acid-sodium citrate buffer, then add 4.0 g of sodium chloride, 0.1 g of disodium edetate, and 0.05 g of thimerosal solution to the above-mentioned drug solution, and then add Add an appropriate amount of water for injection to dissolve by ultrasonic; add 0.01g of polycarbophil, and shear with high shear equipment at 10,000 r / min for 1 minute to fully swell and disperse the polycarbophil; after the polycarbophil is completely swollen and dispersed, cool it down To room temperature, adjust the pH to 6.0-6.5 with 1M sodium hydroxide solution; add 0.1 g of poloxamer 407 to the solution, and then transfer the solution to 4°C, so that the poloxamer 407 is completely dissolved and clear After the solution, add the full amount of water for injection, filter, and divide into packaging; store at 2-8°C.
Embodiment 2
[0033]Example 2: Weigh 1.06 g of azithromycin, 8.0 g of mannitol, 0.1 g of disodium EDTA, and 0.05 g of benzalkonium chloride solution, and dissolve them with an appropriate amount of citric acid-sodium citrate buffer and water for injection ultrasonically; add 0.05g of polycarbophil was sheared for 1 minute with high shear equipment at 10000r / min, so that polycarbophil was fully swollen and dispersed; A mixed solution of sodium and potassium hydroxide (molar ratio of 1:1) was adjusted to pH 6.0-6.5; 15g of carbomer was added to the solution, and then the solution was transferred to 4°C to completely dissolve the carbomer and obtain a clear After the solution, add water for injection to the full amount, filter, and divide into packaging; store at 2-8°C.
Embodiment 3
[0034] Example 3: Weigh the mixture of azithromycin 5.0g, glycerin 2.4g, disodium EDTA 6.0g, paraben A, B, propyl and butyl ester (mass ratio is 70:10:10:10) 2.0 g, dissolve with an appropriate amount of citric acid-sodium citrate buffer and water for injection ultrasonically; add 2.5g of polycarbophil, and shear for 2 minutes with a high-shear equipment at 10,000 r / min to make polycarbophil fully swollen and dispersed; After the polycarbophil was completely swollen and dispersed, it was cooled to room temperature, and the pH was adjusted to 6.0-6.5 with 1M sodium hydroxide solution; The poloxamer 407 was completely dissolved, and after a clear solution was obtained, water for injection was added to the full amount, filtered, and packaged separately; stored at 2-8°C.
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com