Azithromycin gel eye drops and preparation process thereof

A technology of azithromycin and eye drops, which can be applied to medical preparations without active ingredients, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problem of low bioavailability, poor drug absorption, and short retention time. problem, to achieve the effect of reducing drug loss, delaying drug release, and increasing residence time
CN102283799BActive Publication Date: 2013-07-31北京乐维生物技术有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
北京乐维生物技术有限公司
Publication Date
2013-07-31

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Abstract

The invention discloses azithromycin gel eye drops and a preparation process thereof. The eye drops are prepared from a main medicine, namely azithromycin and excipients such as an adhesive, a gel matrix, an isotonic regulator, a preservative, an antioxidant, a buffering agent and the like. The adhesive, namely polycarbophil in the eye drops can increase the biological adhesion of the eye drops, so that the detention time of medicines in eyes is further prolonged. The invention provides a practical, convenient and reliable ophthalmic preparation for treating bacterial conjunctivitis, and solves the problems that the detention time of medicines in an eye drop formulation in the eyes is short, the medicines are not easy to absorb, the bioavailability is low and the like.
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Description

technical field

[0001] The invention relates to an eye drop and a preparation process thereof, in particular to a gel-type eye drop containing azithromycin and a preparation process thereof, and belongs to the technical field of production of ophthalmic pharmaceutical preparations. Background technique

[0002] Bacterial conjunctivitis is the most frequently encountered eye disease in daily ophthalmology first visits. Although bacterial conjunctivitis is considered a self-limiting disease, it is usually treated with antibiotic water-soluble eye drops. As an outstanding representative of a new generation of antibiotics, azithromycin is the only 15-membered ring macrolide antibiotic that has been marketed in the world. Its antibacterial spectrum is similar to that of erythromycin but its antibacterial effect is stronger. It has been widely used in China in recent years.

[0003]

[0004] Azithromycin structural formula

[0005] Its mechanism of action is to interfere with...

Claims

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