Novel preparation method of glucosamine sulfate

Abstract

The invention discloses a novel preparation method of glucosamine sulfate, and belongs to the field of monosaccharide preparation methods. The novel preparation method adopts glucosamine hydrochloride as a raw material and comprises the following steps of treating a glucosamine hydrochloride aqueous solution by a strongly basic anion exchange resin to remove chloridions to obtain glucosamine; neutralizing the glucosamine by a sulfuric acid solution to obtain glucosamine sulfate; and drying the glucosamine sulfate to obtain a glucosamine sulfate preparation without sodium chloride. Specifically, the steps comprises 1) treating 1-25% (W / V) of the glucosamine hydrochloride aqueous solution by the pre-washed strongly basic anion exchange resin column to remove chloridions, 2) collecting effluent liquid obtained from the step 1), 3) adding 20-90% (W / W) of a sulfuric acid solution into the effluent liquid to obtain a glucosamine sulfate aqueous solution by neutralization, wherein a pH value of the glucosamine sulfate aqueous solution is in a range of 3.5 to 5.0; and 4) carrying out a freeze drying process on the glucosamine sulfate aqueous solution, or precipitating the glucosamine sulfate aqueous solution by an organic solvent and then carrying out vacuum drying to obtain a glucosamine sulfate preparation without sodium chloride. The novel preparation method has the advantages of simple process, low cost, less three-waste, and no pollution in production.

Description

technical field [0001] The invention discloses a novel method for preparing glucosamine sulfate, which belongs to the field of monosaccharide preparation methods. Background technique [0002] Glucosamine is a natural amino monosaccharide that exists in the human body and is a necessary substance for the structure of human connective tissue and cell membranes. It is essential for the formation of nails, tendons, skin, eyes, joint fluid, bones, ligaments, and heart valves. It also has an important impact on mucus secretions in the digestive system, respiratory system and urinary system, and is a specific substrate for the production of amino polysaccharides and proteoglycans in the human body. [0003] Glucosamine is prepared from chitin by hydrolysis with hydrochloric acid or sulfuric acid. Glucosamine is commonly used in its sulfate and hydrochloride salts. As early as the 1980s, Italian companies conducted research on glucosamine sulfate and found that it is a specific d...

AI Technical Summary

Problems solved by technology

[0004] The existing commercial glucosamine sulfate is a balanced product of glucosamine hydrochloride and sodium sulfate. Directly mix glucosamine hydrochloride and sodium sulfate, or first dissolve it in water and then dry it to obtain its double salt. The product contains chloride Sodium up to about 20%, patients with cardiovascular disease and kidney disease are not suitable for taking