Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of recyclable surface film of inferior vena cava filter based on (PEG) polyethylene glycol-like

A technology of polyethylene glycol and vena cava, which is applied to filters in blood vessels, ion implantation plating, coating, etc., can solve problems such as chemical modification of difficult vena cava filters, and achieve improved biological decontamination performance, good biological Effects of safety and blood compatibility, good biosafety

Inactive Publication Date: 2012-01-25
CHENGDU SOUTHWEST JIAOTONG UNIV SCI & TECH GARDEN MANAGEMENT +1
View PDF3 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Chemical modification methods, such as silanization methods, for metal materials, the surface lacks reactive groups with PEG molecules, so it is difficult to carry out chemical modification on the surface of the vena cava filter of metal substrates

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of recyclable surface film of inferior vena cava filter based on (PEG) polyethylene glycol-like
  • Preparation method of recyclable surface film of inferior vena cava filter based on (PEG) polyethylene glycol-like
  • Preparation method of recyclable surface film of inferior vena cava filter based on (PEG) polyethylene glycol-like

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Put the inferior vena cava filter made of 316L stainless steel into the plasma polymerization vacuum chamber. When the vacuum is evacuated to 0.5 Pa, argon gas with a flow rate of 2.5 sccm is introduced, and the radio frequency power is 100W, and the negative bias voltage is 80V. 15 minutes of sputtering cleaning; after the sputtering cleaning is completed, the vacuum chamber is re-pumped to 0.5Pa, and then the reaction gas tetraethylene glycol dimethyl ether is introduced to make the working pressure 2Pa, the RF power is 5W, and the negative bias is - Under the conditions of 80V and pulse duty ratio of 10%, the plasma polymerization film deposition was carried out for 30 minutes, that is, a polyethylene glycol (PEG-like) functional film with a thickness of 25 nm was deposited on the surface of the inferior vena cava filter.

Embodiment 2

[0029] Put the inferior vena cava filter of NiTi shape memory alloy material (Ni and Ti atomic ratio 50%) into the plasma polymerization vacuum chamber, when the vacuum is pumped to 0.5Pa, the argon gas with a flow rate of 2.5 sccm is passed in, and the radio frequency power is 100W, 15 minutes of sputter cleaning under the condition of negative bias voltage of 80V; after the sputter cleaning is completed, the vacuum chamber is re-pumped to 0.5Pa, and then the reaction gas tetraethylene glycol dimethyl ether is introduced to make the working pressure 5Pa , the radio frequency power is 30W, the negative bias voltage is-80V, and the pulse duty ratio is 100% under the condition that the plasma polymerization thin film deposition is carried out 120 minutes, promptly deposits on the inferior vena cava filter surface thickness and is the polyethylene glycol of 100nm ( PEG-like) functional film.

Embodiment 3

[0031] Put the inferior vena cava filter made of 316L stainless steel into the plasma polymerization vacuum chamber. When the vacuum is evacuated to 0.5 Pa, argon gas with a flow rate of 2.5 sccm is introduced, and the radio frequency power is 100W, and the negative bias voltage is 80V. 15 minutes of sputtering cleaning; after the sputtering cleaning is completed, the vacuum chamber is re-pumped to 0.5Pa, and then the reaction gas tetraethylene glycol dimethyl ether is introduced to make the working pressure 3Pa, the RF power is 15W, and the negative bias is - Under the conditions of 80V and pulse duty ratio of 30%, the plasma polymerization thin film deposition was carried out for 60 minutes, that is, a polyethylene glycol (PEG-like) functional thin film with a thickness of 50 nm was deposited on the surface of the inferior vena cava filter.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Thicknessaaaaaaaaaa
Login to View More

Abstract

The invention discloses a preparation method of a recyclable surface film of an inferior vena cava filter based on (PEG) polyethylene glycol-like, which comprises the following steps of: feeding the inferior vena cava filter in a plasma polymerization vacuum chamber; when the vacuum degree reaches 0.5Pa, introducing argon gas with the flow of 2.5sccm and carrying out sputter cleaning for 15 minutes under the conditions that the radio-frequency power is 100W and the negative bias voltage is 80V; after the sputter cleaning is finished, vacuumizing the vacuum chamber to be 0.5Pa again; and introducing a reacting gas of tetraglycol dimethyl ether and depositing a plasma polymer thin film for 30-120 minutes under the conditions that the work pressure is 2-5Pa, the radio-frequency power is 5-30W, the negative bias voltage is 80V and the pulse duty factor is 10-100 percent. The inferior vena cava filter prepared by the method disclosed by the invention has strong binding force between the surface-like PEG thin film layer and the inferior vena cava filter and excellent bioremediation performance for resisting protein and cell from adhering.

Description

technical field [0001] The invention relates to functional materials, in particular to the technical field of a recyclable inferior vena cava filter for human body made by a surface modification method. Background technique [0002] Pulmonary embolism is an emergency with high clinical morbidity and mortality, with a case fatality rate of 20% to 30%. It is mostly caused by the shedding of deep vein thrombosis in the lower extremities. Insertion of inferior vena cava filter is an effective means to prevent PE. Most of the currently used venous filters are permanent filters, but the placement of permanent filters can cause long-term complications such as inferior vena cava obstruction, filter displacement, and inferior vena cava injury. Recyclable filters can be safely recovered within a certain time limit, which can effectively avoid the shortage of permanent filters, and have received more and more attention and research in recent years. The "retrievable" properties of cur...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C23C14/28C23C14/12A61F2/01
Inventor 王进杨志禄冷永祥孙鸿黄楠
Owner CHENGDU SOUTHWEST JIAOTONG UNIV SCI & TECH GARDEN MANAGEMENT
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com